Polycythemia risk factors: Difference between revisions

Jump to navigation Jump to search
 
(4 intermediate revisions by the same user not shown)
Line 8: Line 8:
==Risk Factors==
==Risk Factors==


*One of the most common and most dangerous [[complications]] of [[polycythemia vera]] is [[thrombus]] formation. The risk factors are as follows:
*One of the most common and most dangerous [[complications]] of [[polycythemia vera]] is [[thrombus]] formation. The risk factors are as follows:<ref name="BarbuiCarobbio2014">{{cite journal|last1=Barbui|first1=Tiziano|last2=Carobbio|first2=Alessandra|last3=Rumi|first3=Elisa|last4=Finazzi|first4=Guido|last5=Gisslinger|first5=Heinz|last6=Rodeghiero|first6=Francesco|last7=Randi|first7=Maria Luigia|last8=Rambaldi|first8=Alessandro|last9=Gisslinger|first9=Bettina|last10=Pieri|first10=Lisa|last11=Bertozzi|first11=Irene|last12=Casetti|first12=Ilaria|last13=Pardanani|first13=Animesh|last14=Passamonti|first14=Francesco|last15=Vannucchi|first15=Alessandro M.|last16=Tefferi|first16=Ayalew|title=In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology|journal=Blood|volume=124|issue=19|year=2014|pages=3021–3023|issn=0006-4971|doi=10.1182/blood-2014-07-591610}}</ref><ref>{{cite journal|doi=10.36648/1791-809X.14.6.763}}</ref><ref name="pmid9387204">{{cite journal| author=Barbui T, Finazzi G| title=Risk factors and prevention of vascular complications in polycythemia vera. | journal=Semin Thromb Hemost | year= 1997 | volume= 23 | issue= 5 | pages= 455-61 | pmid=9387204 | doi=10.1055/s-2007-996122 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9387204  }}</ref><ref name="pmid28251679">{{cite journal| author=Abdulkarim K, Samuelsson J, Johansson P, Andréasson B| title=Risk factors for vascular complications and treatment patterns at diagnosis of 2389 PV and ET patients: Real-world data from the Swedish MPN Registry. | journal=Eur J Haematol | year= 2017 | volume= 98 | issue= 6 | pages= 577-583 | pmid=28251679 | doi=10.1111/ejh.12873 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28251679  }}</ref>
*Women- usually younger at the time of [[diagnosis]], have a higher risk of arterio-venous [[thrombosis]].
*Women- usually younger at the time of [[diagnosis]], have a higher risk of arterio-venous [[thrombosis]].
*[[Mutation]]- the higher burden of JAK2V617F [[allele]]
*[[Mutation]]- the higher burden of JAK2V617F [[allele]]
*[[Inflammatory]] markers- [[Pentraxins]] play an important role: increased hs-[[CRP]] and a lower [[PTX3]] have a higher risk of [[thrombosis]].
*[[Inflammatory]] markers- [[Pentraxins]] play an important role: increased hs-[[CRP]] and a lower [[PTX3]] have a higher risk of [[thrombosis]].
*Presence of microparticles- responsible for decreased [[thrombin]] inhibition, increased CD41, and an increased chance of [[splenomegaly]].
*Presence of microparticles- responsible for decreased [[thrombin]] inhibition, increased CD41, and an increased chance of [[splenomegaly]].
*[[Neutrophil]] Extracellular Trap formations- NETosis and [[apoptosis]].<ref name="url[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM">{{cite web |url=https://www.dovepress.com/polycythemia-vera-associated-complications-pathogenesis-clinical-manif-peer-reviewed-fulltext-article-JBM |title=[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man &#124; JBM |format= |work= |accessdate=}}</ref>
*[[Neutrophil]] Extracellular Trap formations- NETosis and [[apoptosis]].


==References==
==References==

Latest revision as of 17:19, 2 March 2021

Polycythemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Polycythemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography or Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Polycythemia risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Polycythemia risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Polycythemia risk factors

CDC on Polycythemia risk factors

Polycythemia risk factors in the news

Blogs on Polycythemia risk factors

Directions to Hospitals Treating Polycythemia

Risk calculators and risk factors for Polycythemia risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.

Risk Factors

References

  1. Barbui, Tiziano; Carobbio, Alessandra; Rumi, Elisa; Finazzi, Guido; Gisslinger, Heinz; Rodeghiero, Francesco; Randi, Maria Luigia; Rambaldi, Alessandro; Gisslinger, Bettina; Pieri, Lisa; Bertozzi, Irene; Casetti, Ilaria; Pardanani, Animesh; Passamonti, Francesco; Vannucchi, Alessandro M.; Tefferi, Ayalew (2014). "In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology". Blood. 124 (19): 3021–3023. doi:10.1182/blood-2014-07-591610. ISSN 0006-4971.
  2. . doi:10.36648/1791-809X.14.6.763. Missing or empty |title= (help)
  3. Barbui T, Finazzi G (1997). "Risk factors and prevention of vascular complications in polycythemia vera". Semin Thromb Hemost. 23 (5): 455–61. doi:10.1055/s-2007-996122. PMID 9387204.
  4. Abdulkarim K, Samuelsson J, Johansson P, Andréasson B (2017). "Risk factors for vascular complications and treatment patterns at diagnosis of 2389 PV and ET patients: Real-world data from the Swedish MPN Registry". Eur J Haematol. 98 (6): 577–583. doi:10.1111/ejh.12873. PMID 28251679.

Template:WS Template:WH