Polycythemia risk factors: Difference between revisions

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{{Polycythemia}}
{{Polycythemia}}
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{{CMG}} ; {{AE}} {{Debduti}}


==Overview==
==Overview==
There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.
There are no established [[Risk factor|risk factors]] for developing [[polycythemia vera]] except for the genetic abnormality [[JAK2]]V617F.


==Risk Factors==
==Risk Factors==


*One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:
*One of the most common and most dangerous [[complications]] of [[polycythemia vera]] is [[thrombus]] formation. The risk factors are as follows:<ref name="BarbuiCarobbio2014">{{cite journal|last1=Barbui|first1=Tiziano|last2=Carobbio|first2=Alessandra|last3=Rumi|first3=Elisa|last4=Finazzi|first4=Guido|last5=Gisslinger|first5=Heinz|last6=Rodeghiero|first6=Francesco|last7=Randi|first7=Maria Luigia|last8=Rambaldi|first8=Alessandro|last9=Gisslinger|first9=Bettina|last10=Pieri|first10=Lisa|last11=Bertozzi|first11=Irene|last12=Casetti|first12=Ilaria|last13=Pardanani|first13=Animesh|last14=Passamonti|first14=Francesco|last15=Vannucchi|first15=Alessandro M.|last16=Tefferi|first16=Ayalew|title=In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology|journal=Blood|volume=124|issue=19|year=2014|pages=3021–3023|issn=0006-4971|doi=10.1182/blood-2014-07-591610}}</ref><ref>{{cite journal|doi=10.36648/1791-809X.14.6.763}}</ref><ref name="pmid9387204">{{cite journal| author=Barbui T, Finazzi G| title=Risk factors and prevention of vascular complications in polycythemia vera. | journal=Semin Thromb Hemost | year= 1997 | volume= 23 | issue= 5 | pages= 455-61 | pmid=9387204 | doi=10.1055/s-2007-996122 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9387204  }}</ref><ref name="pmid28251679">{{cite journal| author=Abdulkarim K, Samuelsson J, Johansson P, Andréasson B| title=Risk factors for vascular complications and treatment patterns at diagnosis of 2389 PV and ET patients: Real-world data from the Swedish MPN Registry. | journal=Eur J Haematol | year= 2017 | volume= 98 | issue= 6 | pages= 577-583 | pmid=28251679 | doi=10.1111/ejh.12873 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28251679  }}</ref>
 
*Women- usually younger at the time of [[diagnosis]], have a higher risk of arterio-venous [[thrombosis]].
*Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
*[[Mutation]]- the higher burden of JAK2V617F [[allele]]
*Mutation- higher burden of JAK2V617F allele
*[[Inflammatory]] markers- [[Pentraxins]] play an important role: increased hs-[[CRP]] and a lower [[PTX3]] have a higher risk of [[thrombosis]].
*Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis
*Presence of microparticles- responsible for decreased [[thrombin]] inhibition, increased CD41, and an increased chance of [[splenomegaly]].
*Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly
*[[Neutrophil]] Extracellular Trap formations- NETosis and [[apoptosis]].
*Neutrophil Extracellular Trap formations- NETosis and apoptosis <ref name="url[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM">{{cite web |url=https://www.dovepress.com/polycythemia-vera-associated-complications-pathogenesis-clinical-manif-peer-reviewed-fulltext-article-JBM |title=[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man &#124; JBM |format= |work= |accessdate=}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist|2}}
 
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[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Emergency medicine]]
[[Category:Emergency medicine]]
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[[Category:Blood disorders]]
[[Category:Blood disorders]]
[[Category:Up-To-Date]]
[[Category:Up-To-Date]]
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Latest revision as of 17:19, 2 March 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.

Risk Factors

References

  1. Barbui, Tiziano; Carobbio, Alessandra; Rumi, Elisa; Finazzi, Guido; Gisslinger, Heinz; Rodeghiero, Francesco; Randi, Maria Luigia; Rambaldi, Alessandro; Gisslinger, Bettina; Pieri, Lisa; Bertozzi, Irene; Casetti, Ilaria; Pardanani, Animesh; Passamonti, Francesco; Vannucchi, Alessandro M.; Tefferi, Ayalew (2014). "In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology". Blood. 124 (19): 3021–3023. doi:10.1182/blood-2014-07-591610. ISSN 0006-4971.
  2. . doi:10.36648/1791-809X.14.6.763. Missing or empty |title= (help)
  3. Barbui T, Finazzi G (1997). "Risk factors and prevention of vascular complications in polycythemia vera". Semin Thromb Hemost. 23 (5): 455–61. doi:10.1055/s-2007-996122. PMID 9387204.
  4. Abdulkarim K, Samuelsson J, Johansson P, Andréasson B (2017). "Risk factors for vascular complications and treatment patterns at diagnosis of 2389 PV and ET patients: Real-world data from the Swedish MPN Registry". Eur J Haematol. 98 (6): 577–583. doi:10.1111/ejh.12873. PMID 28251679.

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