Polycythemia medical therapy: Difference between revisions

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==Overview==
==Overview==
*Phlebotomy is used to decrease blood thickness.
*Phlebotomy is used to decrease blood thickness.
*Medicines that may be used include:
*Medicines that may be used include:<ref name="pmid31151982">{{cite journal| author=Spivak JL| title=How I treat polycythemia vera. | journal=Blood | year= 2019 | volume= 134 | issue= 4 | pages= 341-352 | pmid=31151982 | doi=10.1182/blood.2018834044 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31151982  }} </ref>
**Hydroxyurea: reduce the number of red blood cells made by the bone marrow. This drug may be used when the numbers of other blood cell types are also high.
**Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
**Interferon: lower blood counts.
**Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
**Anagrelide: lower platelet counts.
**Anagrelide: used to treat thrombocytosis.
**Ruxolitinib (Jakafi): reduce the number of red blood cells and reduce an enlarged spleen. This drug is prescribed when hydroxyurea and other treatments have failed.
**Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF  and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.  
**Aspirin: reduce the risk of blood clots.
**Aspirin: used to prevent thrombosis.
*Ultraviolet-B light therapy: reduce the itchiness.
*Ultraviolet-B light therapy: reduce the itchiness.



Revision as of 19:47, 6 December 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

  • Phlebotomy is used to decrease blood thickness.
  • Medicines that may be used include:[1]
    • Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
    • Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
    • Anagrelide: used to treat thrombocytosis.
    • Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
    • Aspirin: used to prevent thrombosis.
  • Ultraviolet-B light therapy: reduce the itchiness.

Overview

  • Phlebotomy is used to decrease blood thickness.
  • Medicines that may be used include:[1]
    • Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
    • Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
    • Anagrelide: used to treat thrombocytosis.
    • Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
    • Aspirin: used to prevent thrombosis.
  • Ultraviolet-B light therapy: reduce the itchiness.

References

  1. 1.0 1.1 Spivak JL (2019). "How I treat polycythemia vera". Blood. 134 (4): 341–352. doi:10.1182/blood.2018834044. PMID 31151982.

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