Polycythemia laboratory findings: Difference between revisions
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{{CMG}}; {{AE}}{{Debduti}} | {{CMG}}; {{AE}}{{Debduti}} | ||
== | ==Laboratory Findings== | ||
World Health Organization diagnostic criteria for Polycythemia Vera: | |||
*A1 Elevated RBC mass >25% above mean normal predicted value, or Hb>18.5g/dl in men, 16.5g/dl in women | |||
*A2 No cause of secondary Erythrocytosis include absence of familial Erythrocytosis; no elevation of erythropoietin due to hypoxia (arterial PO2</= 92%), high oxygen affinity hemoglobin, truncated erythropoietin receptors, inappropriate erythropoietin production by tumor | |||
*A3 Splenomegaly | |||
*A4 Clonal genetic abnormality other than Ph chromosome or BCR/ABL fusion gene in marrow cells | |||
*A5 Endogenous erythroid colony formation in vitro | |||
*B1 Thrombocytosis >400x10ª/L | |||
*B2 WBC >12x10ª/L | |||
*B3 Bone marrow biopsy showing panmyelosiswith prominent erythroid and megakaryocytic proliferation | |||
*B4 Low serum EPO levels | |||
==Laboratory Findings== | ==Laboratory Findings== |
Revision as of 17:34, 12 December 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Laboratory Findings
World Health Organization diagnostic criteria for Polycythemia Vera:
- A1 Elevated RBC mass >25% above mean normal predicted value, or Hb>18.5g/dl in men, 16.5g/dl in women
- A2 No cause of secondary Erythrocytosis include absence of familial Erythrocytosis; no elevation of erythropoietin due to hypoxia (arterial PO2</= 92%), high oxygen affinity hemoglobin, truncated erythropoietin receptors, inappropriate erythropoietin production by tumor
- A3 Splenomegaly
- A4 Clonal genetic abnormality other than Ph chromosome or BCR/ABL fusion gene in marrow cells
- A5 Endogenous erythroid colony formation in vitro
- B1 Thrombocytosis >400x10ª/L
- B2 WBC >12x10ª/L
- B3 Bone marrow biopsy showing panmyelosiswith prominent erythroid and megakaryocytic proliferation
- B4 Low serum EPO levels
Laboratory Findings
Laboratory findings consistent with the diagnosis of polycythemia include:
- [Complete blood count CBC]
- [Blood smear]
- [Erythropoietin test]