Polio laboratory findings: Difference between revisions
Joao Silva (talk | contribs) No edit summary |
Joao Silva (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
== Laboratory Findings == | == Laboratory Findings == | ||
===Viral Isolation=== | ===Viral Isolation=== | ||
Poliovirus may be recovered from the stool or pharynx of a person with poliomyelitis. Isolation of virus from the cerebrospinal fluid (CSF) is diagnostic, but is rarely accomplished. If poliovirus is isolated from a person with acute [[flaccid paralysis]], it must be tested | [[Poliovirus]] may be recovered from the stool or [[pharynx]] of a person with poliomyelitis. | ||
Isolation of [[poliovirus|virus]] from the [[cerebrospinal fluid]] (CSF) is diagnostic, but is rarely accomplished. If poliovirus is isolated from a person with acute [[flaccid paralysis]], it must be further tested, using oligonucleotide mapping (fingerprinting) or [[genomic]] sequencing, to determine if the virus is “wild type” or vaccine type.<ref name=CDC>{{cite web | title = Poliomyelitis | url = http://www.cdc.gov/vaccines/pubs/pinkbook/polio.html#epi }}</ref> | |||
===Serology=== | ===Serology=== | ||
Revision as of 15:16, 3 September 2014
|
Polio Microchapters |
|
Causes |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Polio laboratory findings On the Web |
|
American Roentgen Ray Society Images of Polio laboratory findings |
|
Risk calculators and risk factors for Polio laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Laboratory Findings
Viral Isolation
Poliovirus may be recovered from the stool or pharynx of a person with poliomyelitis.
Isolation of virus from the cerebrospinal fluid (CSF) is diagnostic, but is rarely accomplished. If poliovirus is isolated from a person with acute flaccid paralysis, it must be further tested, using oligonucleotide mapping (fingerprinting) or genomic sequencing, to determine if the virus is “wild type” or vaccine type.[1]
Serology
Neutralizing antibodies appear early and may be at high levels by the time the patient is hospitalized; therefore, a fourfold rise in antibody titer may not be demonstrated.[1]
Cerebrospinal Fluid
In poliovirus infection, the CSF usually contains an increased number of white blood cells (10–200 cells/mm3, primarily lymphocytes) and a mildly elevated protein (40–50 mg/100 mL).[1]
References
- ↑ 1.0 1.1 1.2 "Poliomyelitis".