Pheochromocytoma differential diagnosis: Difference between revisions
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Sympathomimetic drugs that can induce symptoms simulating pheochromocytoma include high-dose phenylpropanolamine (a popular over-the-counter decongestant and appetite suppressant), cocaine, amphetamines, phencyclidine, epinephrine, phenylephrine, and terbutaline, and the combination of a monoamine oxidase (MAO) inhibitor and ingestion of tyramine-containing foods [7,26-29]. Mercury intoxication also can mimic pheochromocytoma, producing both hypertension and elevated urine and plasma catecholamines [30]. | |||
Panic disorder can replicate many of the symptoms of pheochromocytoma because it is associated with increased sympathetic activity. Hypertension in these patients occurs primarily during treatment with a tricyclic antidepressant drug, which may increase the degree of sympathetic arousal. | |||
The potential importance of this disorder in the differential diagnosis of pheochromocytoma was illustrated in a study in which 300 adults were referred for possible pheochromocytoma . | |||
==References== | ==References== | ||
Revision as of 18:16, 3 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
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Overview
Pheochromocytoma must be differentiated from anxiety, carcinoid, and hypoglycemia.
Differentiating Pheochromocytoma from other Diseases
The differential diagnosis of pheochromocytoma includes:
- Anxiety disorders
- Carcinoid tumor
- Paragangliomas
- Essential hypertension
- Hyperthyroidism
- Insulinoma
- Paroxysmal supraventricular tachycardia
- Renovascular hypertension
- Hypoglycemia
- Stress
- Exercise
- Medications such as stimulants, methyldopa, and dopamine agonists
Sympathomimetic drugs that can induce symptoms simulating pheochromocytoma include high-dose phenylpropanolamine (a popular over-the-counter decongestant and appetite suppressant), cocaine, amphetamines, phencyclidine, epinephrine, phenylephrine, and terbutaline, and the combination of a monoamine oxidase (MAO) inhibitor and ingestion of tyramine-containing foods [7,26-29]. Mercury intoxication also can mimic pheochromocytoma, producing both hypertension and elevated urine and plasma catecholamines [30].
Panic disorder can replicate many of the symptoms of pheochromocytoma because it is associated with increased sympathetic activity. Hypertension in these patients occurs primarily during treatment with a tricyclic antidepressant drug, which may increase the degree of sympathetic arousal.
The potential importance of this disorder in the differential diagnosis of pheochromocytoma was illustrated in a study in which 300 adults were referred for possible pheochromocytoma .