Pheochromocytoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2] Ifrah Fatima, M.B.B.S[3]

Overview

The most potent risk factor for pheochromocytoma is a family history of multiple endocrine neoplasias, Von Hippel-Lindau disease, neurofibromatosis type 1, hereditary paraganglioma syndromes.

Risk Factors

The most potent risk factor in the development of pheochromocytoma is a family history of multiple endocrine neoplasias, Von Hippel-Lindau disease, neurofibromatosis type 1 or hereditary paraganglioma syndromes.

Common Risk Factors

Less Common Risk Factors

  • Less common risk factors in the development of pheochromocytoma include harboring the following genes:
    • SDHA
    • SDHAF2
    • TMEM127 (transmembrane protein 127)
    • MAX (myc-associated factor X)
    • FH (fumarate hydratase)
    • PDH1, PDH2 (pyruvate dehydrogenase)
    • HIF1alpha (hypoxia-inducible factor)
    • MDH2 (malate dehydrogenase)
    • KIF1Bß (kinesin family member) genes. [2]

References

  1. Gimm O (2005). "Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx". Fam Cancer. 4 (1): 17–23. doi:10.1007/s10689-004-5740-1. PMID 15883706.
  2. Jameson, J (2017). Harrison's Principles of Internal Medicine 19th Edition and Harrison's Manual of Medicine 19th Edition VAL PAK. New York: McGraw-Hill Medical. ISBN 978-1260128857.