Peutz-Jeghers syndrome medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, [[radiotherapy]] or [[chemotherapy]] may be considered. | There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated [[cancer]], [[radiotherapy]] or [[chemotherapy]] may be considered. | ||
==Medical Therapy== | ==Medical Therapy== | ||
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, [[radiotherapy]] or [[chemotherapy]] may be considered. | There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, [[radiotherapy]] or [[chemotherapy]] may be considered. | ||
Patients with Peutz-Jeghers syndrome are treated with intra-operative enteroscopy (IOE) and double balloon enteroscopy (DBE).<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref> | Patients with Peutz-Jeghers syndrome are treated with intra-operative [[enteroscopy]] (IOE) and double balloon [[enteroscopy]] (DBE).<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref> | ||
* | *'''Intra-operative [[enteroscopy]]''' | ||
**Laparotomy (laparoscopy) with endoscopy | **[[Laparotomy]] ([[Laparoscopic surgery|laparoscopy]]) with [[endoscopy]] is done. | ||
**Best modality for diagnostic and therapeutic procedure of the small bowel | **Best modality for diagnostic and therapeutic procedure of the small [[bowel]]. | ||
* | *'''Double balloon [[enteroscopy]]''' | ||
**Allows examination and treatment of the | **Allows examination and treatment of the jejenum and ileum. | ||
* | * '''[[Chemoprophylaxis]]''' | ||
**Proven efficacy of rapamycin for Peutz-Jeghers syndrome in a mouse model | **Proven efficacy of [[rapamycin]] for Peutz-Jeghers syndrome in a mouse model. | ||
== References == | == References == | ||
{{reflist|2}} | {{reflist|2}} | ||
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[[Category:Gastroenterology]] | |||
[[Category:Surgery]] | |||
[[Category:Oncology]] | |||
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[[Category:Pediatrics]] | |||
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Latest revision as of 15:02, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, radiotherapy or chemotherapy may be considered.
Medical Therapy
There is no medical treatment for Peutz-Jeghers syndrome. Depending on the associated cancer, radiotherapy or chemotherapy may be considered.
Patients with Peutz-Jeghers syndrome are treated with intra-operative enteroscopy (IOE) and double balloon enteroscopy (DBE).[1]
- Intra-operative enteroscopy
- Laparotomy (laparoscopy) with endoscopy is done.
- Best modality for diagnostic and therapeutic procedure of the small bowel.
- Double balloon enteroscopy
- Allows examination and treatment of the jejenum and ileum.
- Chemoprophylaxis
- Proven efficacy of rapamycin for Peutz-Jeghers syndrome in a mouse model.
References
- ↑ Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). "Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach". World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.