Peutz-Jeghers syndrome historical perspective: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Peutz-Jeghers syndrome}} | {{Peutz-Jeghers syndrome}} | ||
{{CMG}} {{AE}} {{ | {{CMG}}; {{AE}} {{HQ}} | ||
==Overview== | ==Overview== | ||
In 1998, ''[[STK11]]'' (''LKB1'') mutations were first identified in the pathogenesis of Peutz-Jeghers syndrome. The syndrome is named after Jans Peutz (1886-1957), a Dutch physician and Harold Jeghers (1904-1990), an American physician who had successively described the association between polyposis and the mucocutaneous macules. | In 1998, ''[[STK11]]'' (''LKB1'') mutations were first identified in the pathogenesis of Peutz-Jeghers syndrome. The syndrome is named after Jans Peutz (1886-1957), a Dutch physician and Harold Jeghers (1904-1990), an American physician who had successively described the association between [[polyposis]] and the mucocutaneous [[macules]]. | ||
==Historical Perspective== | ==Historical Perspective== | ||
*In 1895, Peutz-Jeghers syndrome was first discovered by Dr. Connor, a British physician, in identical twin sisters.<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref><ref name="GiardielloTrimbath2006">{{cite journal|last1=Giardiello|first1=F|last2=Trimbath|first2=J|title=Peutz-Jeghers Syndrome and Management Recommendations|journal=Clinical Gastroenterology and Hepatology|volume=4|issue=4|year=2006|pages=408–415|issn=15423565|doi=10.1016/j.cgh.2005.11.005}}</ref> | |||
* | *In 1921, the association between [[gastrointestinal]] [[polyposis]] with distinctive [[pigmentation]] of the [[skin]] and Peutz-Jeghers syndrome was made by Dr. Johannes Peutz of Holland. | ||
*In 1949, Dr. Harold Jeghers of United States was the first to discover the association between combination of intestinal polyposis and skin pigmentation, and the development of Peutz-Jeghers syndrome. | *In 1949, Dr. Harold Jeghers of United States was the first to discover the association between combination of [[intestinal]] [[polyposis]] and [[skin]] [[pigmentation]], and the development of Peutz-Jeghers syndrome. | ||
*In 1954, A. Bruwer used the eponym Peutz-Jeghers syndrome | *In 1954, A. Bruwer used the eponym Peutz-Jeghers syndrome. | ||
*In 1998, serine/threonine-protein kinase 11 alias LKB1 (STK11/LKB1) gene mutations were first implicated in the pathogenesis of Peutz-Jeghers syndrome. | *In 1998, [[serine]]/[[threonine]]-[[protein kinase]] 11 alias [[Peutz-Jeghers syndrome|LKB1 (STK11/LKB1)]] [[gene mutations]] were first implicated in the pathogenesis of Peutz-Jeghers syndrome. | ||
== References == | == References == | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Surgery]] | [[Category:Surgery]] | ||
[[Category:Oncology]] | |||
[[Category:Disease]] | |||
[[Category:Pediatrics]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 14:17, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
In 1998, STK11 (LKB1) mutations were first identified in the pathogenesis of Peutz-Jeghers syndrome. The syndrome is named after Jans Peutz (1886-1957), a Dutch physician and Harold Jeghers (1904-1990), an American physician who had successively described the association between polyposis and the mucocutaneous macules.
Historical Perspective
- In 1895, Peutz-Jeghers syndrome was first discovered by Dr. Connor, a British physician, in identical twin sisters.[1][2]
- In 1921, the association between gastrointestinal polyposis with distinctive pigmentation of the skin and Peutz-Jeghers syndrome was made by Dr. Johannes Peutz of Holland.
- In 1949, Dr. Harold Jeghers of United States was the first to discover the association between combination of intestinal polyposis and skin pigmentation, and the development of Peutz-Jeghers syndrome.
- In 1954, A. Bruwer used the eponym Peutz-Jeghers syndrome.
- In 1998, serine/threonine-protein kinase 11 alias LKB1 (STK11/LKB1) gene mutations were first implicated in the pathogenesis of Peutz-Jeghers syndrome.
References
- ↑ Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). "Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach". World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.
- ↑ Giardiello, F; Trimbath, J (2006). "Peutz-Jeghers Syndrome and Management Recommendations". Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.