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==Risk Factors==
==Risk Factors==
The exact cause of personality disorder remains unknown. However, it usually results from the interplay of genetic and environmental factors. The risk of development of personality disorder is increased by the presence of certain factors such as perinatal injuries, family history, history of substance abuse, childhood abuse and other psychosocial factors.


==Screening==
==Screening==

Revision as of 20:07, 13 July 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Ayesha Anwar, M.B.B.S[2]

Overview

Personality disorders (PD) are described as unique, long-term pervasive patterns of expressing and manifesting emotions, thoughts, and behaviors in an inflexible and maladaptive manner leading to significant functional impairment in one's life. Personality traits, in contrast, are specific patterns of thinking, perceiving, and responding to different situations in an adaptive and tenaciously stable way throughout life. The personality traits formulate an essential aspect in one's life in facing and dealing with contrasting situations as maladaptive personality can result in clinical distress and psychosocial impairment. In order to differentiate normal responses from abnormal or pathological, the criterion employed requires behaviors displayed by a majority in the population as normal and pathological if they are rare or there is the absence of a sense of contentment and adaptability to the social environment or marked deviation from cultural expectations. Hence, these are relative terms, and therefore, the Diagnostic and Statistical Manual of Mental Disorders (DSM) has established a set criterion for diagnosing personality disorders. This is based on the presence of impaired personality functioning and pathological traits. The pathophysiology of PD remains unclear to date. There are countless complex psychodynamic theories explaining the development of the disorder. Both genetic and environmental factors interplay in the causation of PD. A decrease in monoamine oxidase (MAO), and serotonin levels are seen with multiple PD. Although mostly recognized and diagnosed in adults, PD is present and develops in youth and adolescence. About 1 in 10 adolescents meets the criteria for PD. There are ten personality traits classified into 3 clusters; A, B, and C, based on similar characteristics. A clinical criterion as set by DSM-V is used for the diagnosis after the exclusion of other similar conditions (mental health disorder, substance use disorder, structural central nervous system (CNS) disorder). For most personality disorders, an age greater than 18 years is required for the diagnosis. This disorder is retained throughout an individual's life; however, certain types become less intense with age. The presence of PD is associated with increased mortality. The increased mortality is associated with unnatural causes like suicide, accidents, homicide, substance abuse, and depression. Natural death chances may also be enhanced in PD due to negative perspectives and emotions regarding health problems in life and the correlation of impaired mental health with physical health. Alcoholism and substance abuse contribute as precipitating factors and complications in PD. Psychotherapy remains the mainstay of treatment in both management and preventing complications. Medications are used as adjuncts. Cognitive-Behavioral therapy, impulse control, interpersonal psychotherapy, self-help groups, and family therapy are required. Medical therapy is required to balance and restore the neurotransmitter abnormalities associated with PD. Among them, Selective serotonin reuptake inhibitors(SSRIs) and newer antidepressants remain the hallmark. Antipsychotics and mood stabilizers also help. Despite individual and supportive psychotherapy, treatment of PD remains challenging and difficult.

Historical Perspective

Personality defects were started to be recognized in the 18th century. Previously, all the diseases were a result of abnormalities with four bodily fluids; blood, phlegm, yellow bile, and black bile. The changes in them were also considered responsible for variations in mood. However, by the 18th century, Phillippe Pinel described a group of people having impulsive, irrational ways and behaviors while maintaining understanding, perception, judgment, and memory of the actions. This was the birth of recognition of personality disorders. In the 18th century, the term 'phrenology' was used to describe personality characteristics. It was believed that the origin of personality traits is from various facets in the cranium. Despite the discontinuation of the term, it remains significant as it laid the basis for the origin of PDs from the cerebral cortex. In the 19th century and early 20th century, different European psychologists started identifying and describing different personality traits and disorders. The term personality is derived from Greek word, 'persona,' the mask worn in theatres in ancient times to denote a character or social role. It is now used to define that aspect of the person which is discerned by other individuals. In the 1920s and 1930s, Sigmund Freud, known as the father of psychology and his colleagues, worked on the psychoanalytic classification and etiology of personality. They related personality traits with childhood characters. He presented the structural theory that unconscious mental conflicts influence the development of character and behavior [1]. This comprises three components of the brain; the id (primitive urges at birth), ego (mediator that maintains a balance between id and reality), and superego (conscience and moral values). They develop at different stages in life, and the interplay among them is responsible for shaping the personality of a person. Any fixation at any stage is responsible for the improper balance of id and ego and leads to interference in the appropriate and timely development of the superego. A person is born with the id and develops ego and superego at last. This laid down the foundation for further theories and explanations of PDs; however, it lacks the interaction and influences of social, cultural, environmental, and genetic factors in posing the personality in an individual. In the late 1900s, statistics was utilized to group together different definitions of personality structures. It was pioneered by Bernard Cattell. This employs a different number of dimensions to delineate personality systems. These dimensional models lead to DSM characterization of personality disorders according to DSM classifications. DSM II was established in 1986 and listed 10 PDs. It differs from DSM I due to the recognition stage in life being adolescence, while the former states that these disorders exist lifelong. DSM II was based on concepts of psychoanalysis and neuroses, while DSM III described PDs scientifically and clinically. DSM IV was established in 1994 with an updated version, DSM IV-TR, and uses a multiaxial approach to describe psychiatric illnesses with axis II reserved for personality disorder. This multiaxial system was abolished in DSM 5 and categorized the various disorders with related disorders [2]. It classifies PDs into three clusters, with each containing 3-4 disorders.

Classification

There are two approaches used to classify personality disorders; categorical and dimensional. Categorical classification is based on distinct operational criteria depending on behavioral characteristics. DSM-5 and ICD-10 both uses this approach. As compared to this, dimensional classification is based on the personality traits and using a quantitative distinction. It places normality at one end and disorder at other.

Pathophysiology

The exact pathogenesis of personality disorder is not fully understood. Personality disorders are related to multifactorial causes. Throughout time, a multitude of theories has been developed to explain the origin of these disorders. However still, the pathophysiology of PDs remains enigmatic. The five-factor model of personality was developed in the 1980s and 1990s, which demonstrated that it comprises five distinct traits. PDs are primarily the result of positive correlation with Neuroticism and negative association with Agreeableness. Extraversion is associated in both ways . It is a well-known fact that personality develops during childhood and interpersonal experiences and social interactions play a significant role in the development of PDs. Parental maltreatment, stress, and traumatic life events influence the personality adversely. In addition, genetic and prenatal factors also constitute a major role. Genetic factors with mutations in genes involving dopamine and serotonin pathways such as DRD2, COMT, DTNBP1, DAAO, 5-HTTLPR, MAOA, DRD3,TPH1 and TPH2 Perinatal injuries like trauma, infections like encephalitis, and hemorrhage may also be contributing factors. Genetic factors interact with environmental stresses to result in PDs. Various parental behavior like excessive attachment, parental insensitivity or emotional neglect, physical and sexual abuse, and substance use disorders causes an essential impact on PDs development. Social bullying, racial discrimination, frequent dislocations during childhood, and lack of peer support are other risk factors.

==Causes==Causative factors associated with PDs include:

  1. Genetic factors with mutations in genes involving dopamine and serotonin pathways such as DRD2, COMT, DTNBP1, DAAO, 5-HTTLPR, MAOA, DRD3,TPH1 and TPH2.
  2. Environmental factors like stresses, parental treatment, sexual abuse and substance use.

Differentiating Personality disorder from Other Diseases

Epidemiology and Demographics

Worldwide pooled prevalence of personality disorder as found by meta-analysis of studies conducted from 21 countries is 7.8%. Global rates of cluster-A PD is 3.8%, cluster-B is 2.8% and cluster-C PD is 5% [3]. In United States (US), it is around 10%, with major disease burden contributed by obsessive-compulsive PD followed by narcissist and borderline PD. In the rest of countries, it varies [4]. OCD is twice common in females than males and 75% of individuals diagnosed with BPD are females. No sex predilection is found with rest. Narcissist PD is found in 20% of military personals, 17% first-year medical students and 6% forensic population.

Risk Factors

The exact cause of personality disorder remains unknown. However, it usually results from the interplay of genetic and environmental factors. The risk of development of personality disorder is increased by the presence of certain factors such as perinatal injuries, family history, history of substance abuse, childhood abuse and other psychosocial factors.

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

References

  1. "The History of Personality Disorders | HealthyPlace".
  2. Crocq MA (2013). "Milestones in the history of personality disorders". Dialogues Clin Neurosci. 15 (2): 147–53. PMC 3811086. PMID 24174889.
  3. Winsper C, Bilgin A, Thompson A, Marwaha S, Chanen AM, Singh SP; et al. (2020). "The prevalence of personality disorders in the community: a global systematic review and meta-analysis". Br J Psychiatry. 216 (2): 69–78. doi:10.1192/bjp.2019.166. PMID 31298170.
  4. Sansone RA, Sansone LA (2011). "Personality disorders: a nation-based perspective on prevalence". Innov Clin Neurosci. 8 (4): 13–8. PMC 3105841. PMID 21637629.

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