Personality disorder MRI: Difference between revisions
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==MRI== | ==MRI== | ||
Variable data regarding findings on MRI in PD is found. BPD is one of the most prevalent and commonly studied personality disorder and data regarding other types in lacking. Moreover, due to the co-occurence of other mental health conditions with PDs, it becomes difficult to ascertain the specific findings present in neuroimaging in PD. However, most of the studies reveals that changes in BPD is apparent in amygdala and limbic system in the brain. The findings in BPD on neuroimaging represent difference in volume and activity in brain structures. | Variable data regarding findings on MRI in PD is found. BPD is one of the most prevalent and commonly studied personality disorder and data regarding other types in lacking. Moreover, due to the co-occurence of other mental health conditions with PDs, it becomes difficult to ascertain the specific findings present in neuroimaging in PD. However, most of the studies reveals that changes in BPD is apparent in amygdala and limbic system in the brain. The findings in BPD on neuroimaging represent difference in volume and activity in brain structures.The first study was conducted by Lyoo et al. which compared 25 patients with BPD with age and gender matched healthy subjects and demonstrated that individuals with BPD have smaller frontal lobe volume on brain MRI. <ref name="pmid9858082">{{cite journal| author=Lyoo IK, Han MH, Cho DY| title=A brain MRI study in subjects with borderline personality disorder. | journal=J Affect Disord | year= 1998 | volume= 50 | issue= 2-3 | pages= 235-43 | pmid=9858082 | doi=10.1016/s0165-0327(98)00104-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9858082 }} </ref>. More studies conducted by Driessen et al. and Terbartz van Elst et al. found that MRI scans in BPD were associated with smaller volumes of the hippocampus and amygdala than healthier controls (16% and 8% by Driessen et al.) and (20.5% and 24% by Terbartz van Elst et al.). The latter also revealed 24% reduction of the left orbitofrontal and a 26% reduction of the right anterior cingulate cortex in borderline personality disorder. <ref name="pmid11115325">{{cite journal| author=Driessen M, Herrmann J, Stahl K, Zwaan M, Meier S, Hill A | display-authors=etal| title=Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. | journal=Arch Gen Psychiatry | year= 2000 | volume= 57 | issue= 12 | pages= 1115-22 | pmid=11115325 | doi=10.1001/archpsyc.57.12.1115 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11115325 }} </ref>. <ref name="pmid12873806">{{cite journal| author=Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L | display-authors=etal| title=Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. | journal=Biol Psychiatry | year= 2003 | volume= 54 | issue= 2 | pages= 163-71 | pmid=12873806 | doi=10.1016/s0006-3223(02)01743-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12873806 }} </ref>. Another study by Brambilla et al. in 2003 replicated the hippocampus changes in BPD but failed to endorse changes in amygdala. However, it showed the relation of hippocampal changes in BPD with the presence of childhood abuse or trauma. It also demonstrated the increase in putamen in case of concomitant substance abuse in BPD. <ref name="pmid15313519">{{cite journal| author=Brambilla P, Soloff PH, Sala M, Nicoletti MA, Keshavan MS, Soares JC| title=Anatomical MRI study of borderline personality disorder patients. | journal=Psychiatry Res | year= 2004 | volume= 131 | issue= 2 | pages= 125-33 | pmid=15313519 | doi=10.1016/j.pscychresns.2004.04.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313519 }} </ref>. Hence, studies throughout the time have endorsed the findings in hippocampus mostly and in amygdala in some cases. This is the cause of BPD or results due to symptoms of affective dysregualtion in them, remains unclear. | ||
==References== | ==References== | ||
Revision as of 23:10, 29 June 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayesha Anwar, M.B.B.S[2]
Overview
There are no MRI findings associated with [disease name].
OR
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].
MRI
Variable data regarding findings on MRI in PD is found. BPD is one of the most prevalent and commonly studied personality disorder and data regarding other types in lacking. Moreover, due to the co-occurence of other mental health conditions with PDs, it becomes difficult to ascertain the specific findings present in neuroimaging in PD. However, most of the studies reveals that changes in BPD is apparent in amygdala and limbic system in the brain. The findings in BPD on neuroimaging represent difference in volume and activity in brain structures.The first study was conducted by Lyoo et al. which compared 25 patients with BPD with age and gender matched healthy subjects and demonstrated that individuals with BPD have smaller frontal lobe volume on brain MRI. [1]. More studies conducted by Driessen et al. and Terbartz van Elst et al. found that MRI scans in BPD were associated with smaller volumes of the hippocampus and amygdala than healthier controls (16% and 8% by Driessen et al.) and (20.5% and 24% by Terbartz van Elst et al.). The latter also revealed 24% reduction of the left orbitofrontal and a 26% reduction of the right anterior cingulate cortex in borderline personality disorder. [2]. [3]. Another study by Brambilla et al. in 2003 replicated the hippocampus changes in BPD but failed to endorse changes in amygdala. However, it showed the relation of hippocampal changes in BPD with the presence of childhood abuse or trauma. It also demonstrated the increase in putamen in case of concomitant substance abuse in BPD. [4]. Hence, studies throughout the time have endorsed the findings in hippocampus mostly and in amygdala in some cases. This is the cause of BPD or results due to symptoms of affective dysregualtion in them, remains unclear.
References
- ↑ Lyoo IK, Han MH, Cho DY (1998). "A brain MRI study in subjects with borderline personality disorder". J Affect Disord. 50 (2–3): 235–43. doi:10.1016/s0165-0327(98)00104-9. PMID 9858082.
- ↑ Driessen M, Herrmann J, Stahl K, Zwaan M, Meier S, Hill A; et al. (2000). "Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization". Arch Gen Psychiatry. 57 (12): 1115–22. doi:10.1001/archpsyc.57.12.1115. PMID 11115325.
- ↑ Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L; et al. (2003). "Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study". Biol Psychiatry. 54 (2): 163–71. doi:10.1016/s0006-3223(02)01743-2. PMID 12873806.
- ↑ Brambilla P, Soloff PH, Sala M, Nicoletti MA, Keshavan MS, Soares JC (2004). "Anatomical MRI study of borderline personality disorder patients". Psychiatry Res. 131 (2): 125–33. doi:10.1016/j.pscychresns.2004.04.003. PMID 15313519.