Patent ductus arteriosus natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, M.B.B.S. [2], Cafer Zorkun, M.D., Ph.D. [3], Ramyar Ghandriz MD[4] Assistant Editor-In-Chief: Kristin Feeney, B.S. [5]

Overview

The natural history of unoperated patients of patent ductus arteriosus (PDA) depends on the amount of left to right shunting. The left to right shunting in turn depends on the size of ductus and the difference in resistance between the left and right side of heart. PDA can cause complications such as heart failure, infective endocarditis, rhythm disturbance, pulmonary hypertension and Eisenmenger syndrome.

Natural History, Complications, and Prognosis

Natural History

Small PDA

Moderate PDA

Large PDA

Complications

Heart Failure[1]

Infective Endocarditis[3]

Rhythm Disturbance

Pulmonary Hypertension[5]

Eisenmenger Syndrome[6]

Prognosis

Prognosis of patent ductus arteriosus varies widely. It depends on:[7]

References

  1. Gillam-Krakauer, Maria; Reese, Jeff (2018). "Diagnosis and Management of Patent Ductus Arteriosus". NeoReviews. 19 (7): e394–e402. doi:10.1542/neo.19-7-e394. ISSN 1526-9906.
  2. "StatPearls". 2020. PMID 28613509.
  3. Satoh, Tadashi; Nishida, Naoki (2008). "Patent Ductus Arteriosus with Infective Endocarditis at Age 92". Internal Medicine. 47 (4): 263–268. doi:10.2169/internalmedicine.47.0445. ISSN 0918-2918.
  4. Wiyono, S. A.; Witsenburg, M.; de Jaegere, P. P. T.; Roos-Hesselink, J. W. (2008). "Patent ductus arteriosus in adults". Netherlands Heart Journal. 16 (7): 255–259. doi:10.1007/BF03086157. ISSN 1568-5888.
  5. Lehner, Anja; Ulrich, Sarah; Happel, Christoph M.; Fischer, Marcus; Kantzis, Marinos; Schulze-Neick, Ingram; Haas, Nikolaus A. (2017). "Closure of very large PDA with pulmonary hypertension: Initial clinical case-series with the new Occlutech®PDA occluder". Catheterization and Cardiovascular Interventions. 89 (4): 718–725. doi:10.1002/ccd.26856. ISSN 1522-1946.
  6. Kumar, Prakash; Sinha, Santosh Kumar; Pandey, Umeshwar; Thakur, Ramesh; Varma, Chandra Mohan; Sachan, Mohit; Goel, Amit (2016). "Patent Ductus Arteriosus With Eisenmenger Syndrome: Difficult Diagnosis Made Easily With Saline Contrast Echocardiography". Cardiology Research. 7 (3): 117–118. doi:10.14740/cr447w. ISSN 1923-2829.
  7. Benn J (1947). "THE PROGNOSIS OF PATENT DUCTUS ARTERIOSUS". Br Heart J. 9 (4): 283–91. doi:10.1136/hrt.9.4.283. PMC 503595. PMID 18610079.

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