Patent ductus arteriosus causes

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Causes

Familial cases of PDA have been recorded, but a genetic cause has not been determined.

Chromosomal abnormalities are associated with persistent patency of the ductus arteriosus.

Implicated teratogens include congenital rubella (associated with PDA and pulmonary artery branch stenosis), maternal amphetamine use, maternal phenytoin use, and fetal alcohol syndrome.