Paroxysmal nocturnal hemoglobinuria diagnostic study of choice: Difference between revisions
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== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
=== Minimal essential diagnostic criteria === | === Minimal essential diagnostic criteria === | ||
* Diagnosis of paroxysmal nocturnal hemoglobinuria is based on the minimal essential diagnostic criteria. The main diagnostic test for this criteria is [[flow cytometry]]. | * Diagnosis of paroxysmal nocturnal hemoglobinuria is based on the minimal essential diagnostic criteria. The main diagnostic test for this criteria is [[flow cytometry]].<ref name="pmid16051736">{{cite journal| author=Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R et al.| title=Diagnosis and management of paroxysmal nocturnal hemoglobinuria. | journal=Blood | year= 2005 | volume= 106 | issue= 12 | pages= 3699-709 | pmid=16051736 | doi=10.1182/blood-2005-04-1717 | pmc=1895106 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16051736 }}</ref> | ||
* The flow cytometry approach is used to reveal the deficiency of [[GPI anchor]] on the [[RBCs]]. | * The flow cytometry approach is used to reveal the deficiency of [[GPI anchor]] on the [[RBCs]]. | ||
* Other measures used in the diagnostic criteria include the folllowing: | * Other measures used in the diagnostic criteria include the folllowing: | ||
** Assessment of the [[hemolytic]] parameters | ** Assessment of the [[hemolytic]] parameters | ||
** [[Bone marrow]] examination | ** [[Bone marrow]] examination | ||
* Supporting tests are included also in order to detect the PNH category. Below tables conclude both supporting tests and categories of PNH . | * Supporting tests are included also in order to detect the PNH category. Below tables conclude both supporting tests and categories of PNH.<ref name="pmid21707954">{{cite journal| author=Pu JJ, Brodsky RA| title=Paroxysmal nocturnal hemoglobinuria from bench to bedside. | journal=Clin Transl Sci | year= 2011 | volume= 4 | issue= 3 | pages= 219-24 | pmid=21707954 | doi=10.1111/j.1752-8062.2011.00262.x | pmc=3128433 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21707954 }}</ref> | ||
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Revision as of 18:03, 7 November 2018
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Differentiating Paroxysmal nocturnal hemoglobinuria from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Diagnostic Study of Choice
Minimal essential diagnostic criteria
- Diagnosis of paroxysmal nocturnal hemoglobinuria is based on the minimal essential diagnostic criteria. The main diagnostic test for this criteria is flow cytometry.[1]
- The flow cytometry approach is used to reveal the deficiency of GPI anchor on the RBCs.
- Other measures used in the diagnostic criteria include the folllowing:
- Assessment of the hemolytic parameters
- Bone marrow examination
- Supporting tests are included also in order to detect the PNH category. Below tables conclude both supporting tests and categories of PNH.[2]
Category of PNH | Characteristics |
---|---|
1- Classic PNH |
|
2- PNH in the setting of another specified bone marrow disorder |
|
3- Subclinical PNH |
|
References
- ↑ Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.
- ↑ Pu JJ, Brodsky RA (2011). "Paroxysmal nocturnal hemoglobinuria from bench to bedside". Clin Transl Sci. 4 (3): 219–24. doi:10.1111/j.1752-8062.2011.00262.x. PMC 3128433. PMID 21707954.