Pancreatic fistula pathophysiology: Difference between revisions

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(Created page with "__NOTOC__ {{Pancreatic_fistula}} {{CMG}} ==Overview== ==Pathophysiology== ===External Pancreatic Fistulas=== An external pancreatic fistula is an abnormal communication betw...")
 
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==Pathophysiology==
==Pathophysiology==
===External Pancreatic Fistulas===
===External Pancreatic Fistulas===
An external pancreatic fistula is an abnormal communication between the [[pancreas]] (actually [[pancreatic duct]]) and the exterior of the body via the abdominal wall.
===Physiology===
The normal physiology of [name of process] can be understood as follows:


Loss of [[bicarbonate]]-rich pancreatic fluid via a pancreatic [[fistula]] can result in a hyperchloraemic or normal [[anion gap]] [[metabolic acidosis]]. Loss of a small volume of fluid will not cause a problem but an acidosis is common if the volume of pancreatic fluid lost from the body is large.
===Pathogenesis===
 
*The exact pathogenesis of [disease name] is not completely understood.
===Internal Pancreatic Fistulas===
OR
Internal pancreatic fistuals are most commonly cause by disruption of the pancreatic duct due to [[chronic pancreatitis]]. The chronic pancreatitis is usually alcoholic in origin in adults, and traumatic in origin in children. They may also be caused by leakage from a pancreatic pseudocyst.  Internal pancreatic fistulas can result in pancreatic ascites, mediastinital pseudocysts, enzymatic mediastinitis, or pancreatic pleural effusions, depending on the flow of pancreatic secretions from a disrupted pancreatic duct or leakage from a pseudocyst (Cameron et al, 1976)<ref>{{cite journal | author=Kaman L, Behera A, Singh R, Katariya RN | title=Internal pancreatic fistulas with pancreatic ascites and pancreatic pleural effusions: recognition and management | journal=ANZ J Surg | year=2001 | pages=221-5 | volume=71 | issue=4  | id=PMID 11355730}}</ref><ref>{{cite journal | author=Lipsett PA, Cameron JL | title=Internal pancreatic fistula | journal=Am J Surg | year=1992 | pages=216-20 | volume=163 | issue=2  | id=PMID 1739176}}</ref>.
*It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
*[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
*Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
*[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
*The progression to [disease name] usually involves the [molecular pathway].
*The pathophysiology of [disease/malignancy] depends on the histological subtype.


==References==
==References==

Revision as of 18:44, 3 March 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

External Pancreatic Fistulas

Physiology

The normal physiology of [name of process] can be understood as follows:

Pathogenesis

  • The exact pathogenesis of [disease name] is not completely understood.

OR

  • It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
  • [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
  • Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
  • [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
  • The progression to [disease name] usually involves the [molecular pathway].
  • The pathophysiology of [disease/malignancy] depends on the histological subtype.

References

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