Pancreatic cancer causes: Difference between revisions
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==Causes== | ==Causes== | ||
*[[Pancreatic cancer]] may be caused by the following: <ref name="pmid27546841">{{cite journal| author=Yabar CS, Winter JM| title=Pancreatic Cancer: A Review. | journal=Gastroenterol Clin North Am | year= 2016 | volume= 45 | issue= 3 | pages= 429-45 | pmid=27546841 | doi=10.1016/j.gtc.2016.04.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27546841 }} </ref> <ref name="pmid25207767">{{cite journal| author=Ryan DP, Hong TS, Bardeesy N| title=Pancreatic adenocarcinoma. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 11 | pages= 1039-49 | pmid=25207767 | doi=10.1056/NEJMra1404198 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25207767 }} </ref> <ref name="pmid26320426">{{cite journal| author=Goral V| title=Pancreatic Cancer: Pathogenesis and Diagnosis. | journal=Asian Pac J Cancer Prev | year= 2015 | volume= 16 | issue= 14 | pages= 5619-24 | pmid=26320426 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26320426 }} </ref> | *[[Pancreatic cancer]] may be caused by the following:<ref name="pmid27546841">{{cite journal| author=Yabar CS, Winter JM| title=Pancreatic Cancer: A Review. | journal=Gastroenterol Clin North Am | year= 2016 | volume= 45 | issue= 3 | pages= 429-45 | pmid=27546841 | doi=10.1016/j.gtc.2016.04.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27546841 }} </ref><ref name="pmid25207767">{{cite journal| author=Ryan DP, Hong TS, Bardeesy N| title=Pancreatic adenocarcinoma. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 11 | pages= 1039-49 | pmid=25207767 | doi=10.1056/NEJMra1404198 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25207767 }} </ref><ref name="pmid26320426">{{cite journal| author=Goral V| title=Pancreatic Cancer: Pathogenesis and Diagnosis. | journal=Asian Pac J Cancer Prev | year= 2015 | volume= 16 | issue= 14 | pages= 5619-24 | pmid=26320426 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26320426 }} </ref> | ||
** | **Inactivation of [[Tumor suppressor gene|tumor suppressor genes]] | ||
** | **Activation of [[Oncogene|oncogenes]] | ||
** | **Deregulation of molecules in various [[Signal transduction|signaling pathways]] | ||
* | *Inactivation of tumor suppressor genes: | ||
**[[Tumor suppressor gene|Tumor suppressor genes]] may be inactivated by: | **[[Tumor suppressor gene|Tumor suppressor genes]] may be inactivated by: | ||
***[[Mutation]] | ***[[Mutation]] | ||
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***BRCA2 | ***BRCA2 | ||
* | *Activation of [[Oncogene|oncogenes]] | ||
**[[Oncogene|Oncogenes]] may be activated by: | **[[Oncogene|Oncogenes]] may be activated by: | ||
***[[Amplification]] | ***[[Amplification]] | ||
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***[[Cyclin D1]] | ***[[Cyclin D1]] | ||
* | *Deregulation of molecules in various [[Signal transduction|signaling pathways]]: | ||
**[[Genomics|Genomic]] alterations of [[EGFR]] include the following: | **[[Genomics|Genomic]] alterations of [[EGFR]] include the following: | ||
***[[Deletion (genetics)|Deletion]] | ***[[Deletion (genetics)|Deletion]] |
Revision as of 22:36, 20 November 2017
Pancreatic cancer Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Pancreatic cancer may be caused by the inactivation of tumor suppressor genes such as p53, p16, p27CIP1 and BRCA2. Oncogenes such as Ras , Cox-2, Akt-2, Notch and Cyclin D1 may undergo activation and lead to the development of pancreatic cancer. Deregulation and crosstalk between different signal transduction pathways due to genomic alterations also have a proven role in the causation of pancreatic cancer.
Causes
- Pancreatic cancer may be caused by the following:[1][2][3]
- Inactivation of tumor suppressor genes
- Activation of oncogenes
- Deregulation of molecules in various signaling pathways
- Inactivation of tumor suppressor genes:
- Tumor suppressor genes may be inactivated by:
- Tumor suppressor genes:
- p53
- p16
- p27CIP1
- BRCA2
- Deregulation of molecules in various signaling pathways:
References
- ↑ Yabar CS, Winter JM (2016). "Pancreatic Cancer: A Review". Gastroenterol Clin North Am. 45 (3): 429–45. doi:10.1016/j.gtc.2016.04.003. PMID 27546841.
- ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
- ↑ Goral V (2015). "Pancreatic Cancer: Pathogenesis and Diagnosis". Asian Pac J Cancer Prev. 16 (14): 5619–24. PMID 26320426.