Palmar plantar erythrodysesthesia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zain Fatiwala, M.D.
Overview
Palmar plantar erthrodysesthesia usually presents in patients being treated with chemotherapeutic agents. The classic presentation is tingling and/or numbness of the palms and soles that evolve into painful, symmetric, and well0demarcated swelling and red plaques. Subsequently, the skin peels and resolution occurs. Painful red swelling of the hands and feet in a patient receiving chemotherapy is usually enough to make the diagnosis..
History and symptoms
The symptoms can occur anywhere between days to months after administration of the offending medication, depending on the dose and speed of administration (Baack and Burgdorf, 1991; Demirçay, 1997;). The patient first experiences tingling and/or numbness of the palms and soles that evolves into painful, symmetric, and well-demarcated swelling and red plaques. This is followed by peeling of the skin and resolution of the symptoms (Apisarnthanarax and Duvic 2003). Painful red swelling of the hands and feet in a patient receiving chemotherapy is usually enough to make the diagnosis.