Palmar plantar erythrodysesthesia history and symptoms: Difference between revisions

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==History and Symptoms==
==History and Symptoms==
=== Common Symptoms ===
The most common symptoms of PPE include:
The most common symptoms of PPE include:


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* The palms of the hands are usually more frequently and more severely affected than the soles of the feet, and may be only are affected.<ref name="pmid2061446">{{cite journal| author=Baack BR, Burgdorf WH| title=Chemotherapy-induced acral erythema. | journal=J Am Acad Dermatol | year= 1991 | volume= 24 | issue= 3 | pages= 457-61 | pmid=2061446 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2061446  }} </ref> <ref name="pmid15341880">{{cite journal| author=Lassere Y, Hoff P| title=Management of hand-foot syndrome in patients treated with capecitabine (Xeloda). | journal=Eur J Oncol Nurs | year= 2004 | volume= 8 Suppl 1 | issue=  | pages= S31-40 | pmid=15341880 | doi=10.1016/j.ejon.2004.06.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15341880  }} </ref>
* The palms of the hands are usually more frequently and more severely affected than the soles of the feet, and may be only are affected.<ref name="pmid2061446">{{cite journal| author=Baack BR, Burgdorf WH| title=Chemotherapy-induced acral erythema. | journal=J Am Acad Dermatol | year= 1991 | volume= 24 | issue= 3 | pages= 457-61 | pmid=2061446 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2061446  }} </ref> <ref name="pmid15341880">{{cite journal| author=Lassere Y, Hoff P| title=Management of hand-foot syndrome in patients treated with capecitabine (Xeloda). | journal=Eur J Oncol Nurs | year= 2004 | volume= 8 Suppl 1 | issue=  | pages= S31-40 | pmid=15341880 | doi=10.1016/j.ejon.2004.06.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15341880  }} </ref>


Other reported symptoms and signs include: <ref name="pmid11034047">{{cite journal| author=Hui YF, Cortes JE| title=Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin. | journal=Pharmacotherapy | year= 2000 | volume= 20 | issue= 10 | pages= 1221-3 | pmid=11034047 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11034047  }} </ref> <ref name="urlwww.oncologynurseadvisor.com">{{cite web |url=https://www.oncologynurseadvisor.com/home/departments/ce-courses/prevention-and-management-of-hand-foot-syndromes/ |title=www.oncologynurseadvisor.com |format= |work= |accessdate=}}</ref>
<br />
 
=== Less Common Symptoms ===
Less common symptoms include: <ref name="pmid11034047">{{cite journal| author=Hui YF, Cortes JE| title=Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin. | journal=Pharmacotherapy | year= 2000 | volume= 20 | issue= 10 | pages= 1221-3 | pmid=11034047 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11034047  }} </ref> <ref name="urlwww.oncologynurseadvisor.com">{{cite web |url=https://www.oncologynurseadvisor.com/home/departments/ce-courses/prevention-and-management-of-hand-foot-syndromes/ |title=www.oncologynurseadvisor.com |format= |work= |accessdate=}}</ref>


* Sensory impairment
* Sensory impairment
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* A bullous variant (a severe form of this entity) specifically occurs with cytarabine or methotrexate.<ref name="pmid8624164">{{cite journal| author=Hellier I, Bessis D, Sotto A, Margueritte G, Guilhou JJ| title=High-dose methotrexate-induced bullous variant of acral erythema. | journal=Arch Dermatol | year= 1996 | volume= 132 | issue= 5 | pages= 590-1 | pmid=8624164 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8624164  }} </ref><ref name="pmid8420487">{{cite journal| author=Waltzer JF, Flowers FP| title=Bullous variant of chemotherapy-induced acral erythema. | journal=Arch Dermatol | year= 1993 | volume= 129 | issue= 1 | pages= 43-5 | pmid=8420487 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8420487  }} </ref>
* A bullous variant (a severe form of this entity) specifically occurs with cytarabine or methotrexate.<ref name="pmid8624164">{{cite journal| author=Hellier I, Bessis D, Sotto A, Margueritte G, Guilhou JJ| title=High-dose methotrexate-induced bullous variant of acral erythema. | journal=Arch Dermatol | year= 1996 | volume= 132 | issue= 5 | pages= 590-1 | pmid=8624164 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8624164  }} </ref><ref name="pmid8420487">{{cite journal| author=Waltzer JF, Flowers FP| title=Bullous variant of chemotherapy-induced acral erythema. | journal=Arch Dermatol | year= 1993 | volume= 129 | issue= 1 | pages= 43-5 | pmid=8420487 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8420487  }} </ref>


Involvement of other parts of the body is rare, even though mild erythema or morbilliform lesions might occasionally be seen on the trunk, trunk, neck, chest, scalp and extremitirs4,89.
Involvement of other parts of the body is rare, even though mild erythema or morbilliform lesions might occasionally be seen on the trunk, trunk, neck, chest, scalp and extremitirs. <ref name="pmid2061446">{{cite journal| author=Baack BR, Burgdorf WH| title=Chemotherapy-induced acral erythema. | journal=J Am Acad Dermatol | year= 1991 | volume= 24 | issue= 3 | pages= 457-61 | pmid=2061446 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2061446  }} </ref> <ref name="pmid2528937">{{cite journal| author=Kroll SS, Koller CA, Kaled S, Dreizen S| title=Chemotherapy-induced acral erythema: desquamating lesions involving the hands and feet. | journal=Ann Plast Surg | year= 1989 | volume= 23 | issue= 3 | pages= 263-5 | pmid=2528937 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2528937  }} </ref>
 
 
===History===
Patients with [disease name]] may have a positive history of:
*[History finding 1]
*[History finding 2]
*[History finding 3]


===Common Symptoms===
Common symptoms of [disease] include:
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]


===Less Common Symptoms===
Less common symptoms of [disease name] include
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 19:14, 27 June 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

The majority of patients with [disease name] are asymptomatic.

OR

The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History and Symptoms

Common Symptoms

The most common symptoms of PPE include:

  • A prodrome of dysesthesia, usually as a tingling sensation in the fingers, palms and/or soles, progressing to a burning pain in a few days
  • A well-defined edema and symmetrical erythema, more prominently over the fat pads of the distal phalanges
  • Skip areas may be seen
  • Extension to the dorsal surfaces of the extremities, or over joint surfaces can occur [1]
  • Periungual skin involvement is also possible
  • The palms of the hands are usually more frequently and more severely affected than the soles of the feet, and may be only are affected.[1] [2]


Less Common Symptoms

Less common symptoms include: [3] [4]

  • Sensory impairment
  • paresthesia
  • pruritus
  • A bullous variant (a severe form of this entity) specifically occurs with cytarabine or methotrexate.[5][6]

Involvement of other parts of the body is rare, even though mild erythema or morbilliform lesions might occasionally be seen on the trunk, trunk, neck, chest, scalp and extremitirs. [1] [7]


References

  1. ↑ 1.0 1.1 1.2 Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
  2. ↑ Lassere Y, Hoff P (2004). "Management of hand-foot syndrome in patients treated with capecitabine (Xeloda)". Eur J Oncol Nurs. 8 Suppl 1: S31–40. doi:10.1016/j.ejon.2004.06.007. PMID 15341880.
  3. ↑ Hui YF, Cortes JE (2000). "Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin". Pharmacotherapy. 20 (10): 1221–3. PMID 11034047.
  4. ↑ "www.oncologynurseadvisor.com".
  5. ↑ Hellier I, Bessis D, Sotto A, Margueritte G, Guilhou JJ (1996). "High-dose methotrexate-induced bullous variant of acral erythema". Arch Dermatol. 132 (5): 590–1. PMID 8624164.
  6. ↑ Waltzer JF, Flowers FP (1993). "Bullous variant of chemotherapy-induced acral erythema". Arch Dermatol. 129 (1): 43–5. PMID 8420487.
  7. ↑ Kroll SS, Koller CA, Kaled S, Dreizen S (1989). "Chemotherapy-induced acral erythema: desquamating lesions involving the hands and feet". Ann Plast Surg. 23 (3): 263–5. PMID 2528937.
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