Palmar plantar erythrodysesthesia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D.

Overview

Several different Chemotherapeutic agents have been associated with acral erythema[1]

Causes

Chemotherapy drugs that can cause this syndrome include:

Most frequently associated:


Less frequently associated:

  • Targeted therapy drugs can also cause PPE; however, the clinical and histologic patterns differ from the classic PPE caused by conventional cytotoxic chemotherapeutic agents. These include:
    • Axitinib (Inlyta) [67]
    • Cabozantinib (Cabometyx, Cometriq) [68]
    • Regorafenib (Stivarga)[69]
    • Pazopanibv(Votrient)[73]

References

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