Paget's disease of the breast history and symptoms: Difference between revisions
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===Symptoms=== | ===Symptoms=== | ||
Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: | Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: <ref name="pmid4318756">{{cite journal |vauthors=Ashikari R, Park K, Huvos AG, Urban JA |title=Paget's disease of the breast |journal=Cancer |volume=26 |issue=3 |pages=680–5 |date=September 1970 |pmid=4318756 |doi= |url=}}</ref><ref name="pmid27178684">{{cite journal |vauthors=Tan AR |title=Cutaneous manifestations of breast cancer |journal=Semin. Oncol. |volume=43 |issue=3 |pages=331–4 |date=June 2016 |pmid=27178684 |doi=10.1053/j.seminoncol.2016.02.030 |url=}}</ref><ref name="pmid16174159">{{cite journal |vauthors=Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A |title=Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma |journal=Breast J |volume=11 |issue=5 |pages=355–6 |date=2005 |pmid=16174159 |doi=10.1111/j.1075-122X.2005.21722.x |url=}}</ref> | ||
*[[Puritis]] or [[erythema]] of the nipple and/or areola. | *[[Puritis]] or [[erythema]] of the nipple and/or areola. | ||
*Flaking, crusting, or thickening of the [[skin]] that begins at the nipple and spreads to the areola. | *Flaking, crusting, or thickening of the [[skin]] that begins at the nipple and spreads to the areola. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Symptoms of Paget's disease of the breast include itching, redness, thickened skin, and ulceration of the nipple.
History and symptoms
History
A detailed history documenting the length of time the lesion along with any associated symptoms should be taken.By clinical history, the cancer risk can be evaluated:[1]
- Age at menarche
- Menopausal status
- Number of pregnancies
- Previous history of radiation
- History of oral contraceptives or hormone replacement therapy
- Past history of breast cancer and age at time of diagnosis
- Familial history of breast cancer or ovarian cancer in first-degree relatives
- Other associated breast disease or possible biopsies
Symptoms
Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: [2][3][4]
- Puritis or erythema of the nipple and/or areola.
- Flaking, crusting, or thickening of the skin that begins at the nipple and spreads to the areola.
- Erosion or ulceration of the nipple.
- A flattened or inverted nipple.
- Discharge from the nipple that may be yellowish or bloody.
- A palpable breast mass is present in 50% of patients.
References
- ↑ Shah R, Rosso K, Nathanson SD (2014). "Pathogenesis, prevention, diagnosis and treatment of breast cancer". World J Clin Oncol. 5 (3): 283–98. doi:10.5306/wjco.v5.i3.283. PMC 4127601. PMID 25114845.
- ↑ Ashikari R, Park K, Huvos AG, Urban JA (September 1970). "Paget's disease of the breast". Cancer. 26 (3): 680–5. PMID 4318756.
- ↑ Tan AR (June 2016). "Cutaneous manifestations of breast cancer". Semin. Oncol. 43 (3): 331–4. doi:10.1053/j.seminoncol.2016.02.030. PMID 27178684.
- ↑ Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A (2005). "Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma". Breast J. 11 (5): 355–6. doi:10.1111/j.1075-122X.2005.21722.x. PMID 16174159.