PTPRG: Difference between revisions

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{{Infobox_gene}}
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'''Receptor-type tyrosine-protein phosphatase gamma''' is an [[enzyme]] that in humans is encoded by the ''PTPRG'' [[gene]].<ref name="pmid1711217">{{cite journal | vauthors = LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A| title = Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21 | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 11 | pages = 5036–40 |date=Jul 1991 | pmid = 1711217 | pmc = 51802 | doi =10.1073/pnas.88.11.5036 |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5793| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PTPRG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h4v.
| PDB = {{PDB2|2h4v}}, {{PDB2|2hy3}}, {{PDB2|2nlk}}, {{PDB2|2pbn}}
| Name = Protein tyrosine phosphatase, receptor type, G
| HGNCid = 9671
| Symbol = PTPRG
| AltSymbols =; HPTPG; PTPG; R-PTP-GAMMA; RPTPG
| OMIM = 176886
| ECnumber = 
| Homologene = 2129
| MGIid = 97814
| Function = {{GNF_GO|id=GO:0004089 |text = carbonate dehydratase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005001 |text = transmembrane receptor protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0006730 |text = one-carbon compound metabolic process}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5793
    | Hs_Ensembl = ENSG00000144724
    | Hs_RefseqProtein = NP_002832
    | Hs_RefseqmRNA = NM_002841
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 61523002
    | Hs_GenLoc_end = 62255613
    | Hs_Uniprot = P23470
    | Mm_EntrezGene = 19270
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_976892
    | Mm_RefseqProtein = XP_981986
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Protein tyrosine phosphatase, receptor type, G''', also known as '''PTPRG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5793| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.<ref name="entrez">{{cite web | title = Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5793| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.<ref name="entrez">{{cite web | title = Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5793| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=LaForgia S, Morse B, Levy J, ''et al.'' |title=Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 11 |pages= 5036-40 |year= 1991 |pmid= 1711217 |doi=  }}
*{{cite journal   |vauthors=Kaplan R, Morse B, Huebner K, etal |title=Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 18 |pages= 7000–4 |year= 1990 |pmid= 2169617 |doi=10.1073/pnas.87.18.7000  | pmc=54670 }}
*{{cite journal  | author=Kaplan R, Morse B, Huebner K, ''et al.'' |title=Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 18 |pages= 7000-4 |year= 1990 |pmid= 2169617 |doi=  }}
*{{cite journal  | vauthors=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241–52 |year= 1990 |pmid= 2170109 |doi= | pmc=552056 }}
*{{cite journal  | author=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241-52 |year= 1990 |pmid= 2170109 |doi=  }}
*{{cite journal   |vauthors=Latif F, Tory K, Modi W, etal |title=A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene. |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 91 |year= 1993 |pmid= 7683956 |doi=10.1093/hmg/2.1.91 }}
*{{cite journal | author=Latif F, Tory K, Modi W, ''et al.'' |title=A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene. |journal=Hum. Mol. Genet. |volume=2 |issue= 1 |pages= 91 |year= 1993 |pmid= 7683956 |doi=  }}
*{{cite journal   |vauthors=Barnea G, Silvennoinen O, Shaanan B, etal |title=Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1497–506 |year= 1993 |pmid= 8382771 |doi= | pmc=359461 }}
*{{cite journal | author=Barnea G, Silvennoinen O, Shaanan B, ''et al.'' |title=Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1497-506 |year= 1993 |pmid= 8382771 |doi=  }}
*{{cite journal   |vauthors=Kastury K, Ohta M, Lasota J, etal |title=Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. |journal=Genomics |volume=32 |issue= 2 |pages= 225–35 |year= 1997 |pmid= 8833149 |doi= 10.1006/geno.1996.0109 }}
*{{cite journal | author=Kastury K, Ohta M, Lasota J, ''et al.'' |title=Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. |journal=Genomics |volume=32 |issue= 2 |pages= 225-35 |year= 1997 |pmid= 8833149 |doi= 10.1006/geno.1996.0109 }}
*{{cite journal  | vauthors=van Niekerk CC, Poels LG |title=Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors. |journal=Cancer Lett. |volume=137 |issue= 1 |pages= 61–73 |year= 1999 |pmid= 10376795 |doi=10.1016/S0304-3835(98)00344-9 }}
*{{cite journal  | author=van Niekerk CC, Poels LG |title=Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors. |journal=Cancer Lett. |volume=137 |issue= 1 |pages= 61-73 |year= 1999 |pmid= 10376795 |doi=  }}
*{{cite journal   |vauthors=Kawachi H, Tamura H, Watakabe I, etal |title=Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family. |journal=Brain Res. Mol. Brain Res. |volume=72 |issue= 1 |pages= 47–54 |year= 1999 |pmid= 10521598 |doi=10.1016/S0169-328X(99)00204-1 }}
*{{cite journal | author=Kawachi H, Tamura H, Watakabe I, ''et al.'' |title=Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family. |journal=Brain Res. Mol. Brain Res. |volume=72 |issue= 1 |pages= 47-54 |year= 1999 |pmid= 10521598 |doi=  }}
*{{cite journal   |vauthors=Liu S, Kulp SK, Sugimoto Y, etal |title=Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. |journal=Breast Cancer Res. Treat. |volume=71 |issue= 1 |pages= 21–35 |year= 2002 |pmid= 11859871 |doi=10.1023/A:1013343718942 }}
*{{cite journal | author=Liu S, Kulp SK, Sugimoto Y, ''et al.'' |title=Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. |journal=Breast Cancer Res. Treat. |volume=71 |issue= 1 |pages= 21-35 |year= 2002 |pmid= 11859871 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Liu S, Sugimoto Y, Kulp SK, etal |title=Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. |journal=Anticancer Res. |volume=22 |issue= 6C |pages= 3917–23 |year= 2003 |pmid= 12553013 |doi=  }}
*{{cite journal | author=Liu S, Sugimoto Y, Kulp SK, ''et al.'' |title=Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. |journal=Anticancer Res. |volume=22 |issue= 6C |pages= 3917-23 |year= 2003 |pmid= 12553013 |doi=  }}
*{{cite journal   |vauthors=Liu S, Sugimoto Y, Sorio C, etal |title=Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7. |journal=Oncogene |volume=23 |issue= 6 |pages= 1256–62 |year= 2004 |pmid= 14676845 |doi= 10.1038/sj.onc.1207235 }}
*{{cite journal | author=Liu S, Sugimoto Y, Sorio C, ''et al.'' |title=Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7. |journal=Oncogene |volume=23 |issue= 6 |pages= 1256-62 |year= 2004 |pmid= 14676845 |doi= 10.1038/sj.onc.1207235 }}
*{{cite journal   |vauthors=van Doorn R, Zoutman WH, Dijkman R, etal |title=Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. |journal=J. Clin. Oncol. |volume=23 |issue= 17 |pages= 3886–96 |year= 2005 |pmid= 15897551 |doi= 10.1200/JCO.2005.11.353 }}
*{{cite journal | author=van Doorn R, Zoutman WH, Dijkman R, ''et al.'' |title=Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. |journal=J. Clin. Oncol. |volume=23 |issue= 17 |pages= 3886-96 |year= 2005 |pmid= 15897551 |doi= 10.1200/JCO.2005.11.353 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5793}}
{{Protein tyrosine phosphatases}}
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Latest revision as of 18:58, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.[2]

References

  1. ↑ LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A, et al. (Jul 1991). "Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21". Proc Natl Acad Sci U S A. 88 (11): 5036–40. doi:10.1073/pnas.88.11.5036. PMC 51802. PMID 1711217.
  2. ↑ 2.0 2.1 "Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G".

Further reading



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