PRSS8: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Prostasin''' is a [[protein]] that in humans is encoded by the ''PRSS8'' [[gene]].<ref name="pmid8838796">{{cite journal | vauthors = Yu JX, Chao L, Ward DC, Chao J | title = Structure and chromosomal localization of the human prostasin (PRSS8) gene | journal = Genomics | volume = 32 | issue = 3 | pages = 334–40 | date = Mar 1996 | pmid = 8838796 | pmc =  | doi = 10.1006/geno.1996.0127 }}</ref><ref name="pmid7768952">{{cite journal | vauthors = Yu JX, Chao L, Chao J | title = Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA | journal = The Journal of Biological Chemistry | volume = 270 | issue = 22 | pages = 13483–9 | date = Jun 1995 | pmid = 7768952 | pmc = | doi = 10.1074/jbc.270.22.13483 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRSS8 protease, serine, 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5652| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[trypsinogen]], which is a member of the trypsin family of [[serine protease]]s. This [[enzyme]] is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of [[lysine]] or [[arginine]].
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protease, serine, 8
| HGNCid = 9491
| Symbol = PRSS8
| AltSymbols =; CAP1; PROSTASIN
| OMIM = 600823
| ECnumber = 
| Homologene = 20613
| MGIid = 1923810
| GeneAtlas_image1 = PBB_GE_PRSS8_202525_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5652
    | Hs_Ensembl = ENSG00000052344
    | Hs_RefseqProtein = NP_002764
    | Hs_RefseqmRNA = NM_002773
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 31050284
    | Hs_GenLoc_end = 31054320
    | Hs_Uniprot = Q16651
    | Mm_EntrezGene = 76560
    | Mm_Ensembl = ENSMUSG00000030800
    | Mm_RefseqmRNA = NM_133351
    | Mm_RefseqProtein = NP_579929
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 127716865
    | Mm_GenLoc_end = 127721030
    | Mm_Uniprot = Q9ESD1
  }}
}}
'''Protease, serine, 8''', also known as '''PRSS8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRSS8 protease, serine, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5652| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein is implicated in [[Epithelium|epithelial]] [[sodium channel]] regulation<ref>{{cite journal | vauthors = Koda A, Wakida N, Toriyama K, Yamamoto K, Iijima H, Tomita K, Kitamura K | title = Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity | journal = Hypertension Research | volume = 32 | issue = 4 | pages = 276–81 | date = Apr 2009 | pmid = 19262497 | doi = 10.1038/hr.2009.6 | url = http://www.nature.com/hr/journal/v32/n4/full/hr20096a.html }}</ref> and may help regulate a variety of tissue functions that involve a sodium channel.<ref>{{cite journal | vauthors = Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y | title = Prostasin: a possible candidate gene for human hypertension | journal = American Journal of Hypertension | volume = 21 | issue = 9 | pages = 1028–33 | date = Sep 2008 | pmid = 18583984 | pmc = 3812941 | doi = 10.1038/ajh.2008.224 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.<ref name="entrez">{{cite web | title = Entrez Gene: PRSS8 protease, serine, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5652| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yu JX, Chao L, Chao J | title = Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland | journal = The Journal of Biological Chemistry | volume = 269 | issue = 29 | pages = 18843–8 | date = Jul 1994 | pmid = 8034638 | doi =  }}
| citations =
* {{cite journal | vauthors = Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K | title = Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 6 | pages = 3114–9 | date = Mar 1999 | pmid = 10077646 | pmc = 15904 | doi = 10.1073/pnas.96.6.3114 }}
*{{cite journal  | author=Yu JX, Chao L, Chao J |title=Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13483-9 |year= 1995 |pmid= 7768952 |doi=  }}
* {{cite journal | vauthors = Chen LM, Skinner ML, Kauffman SW, Chao J, Chao L, Thaler CD, Chai KX | title = Prostasin is a glycosylphosphatidylinositol-anchored active serine protease | journal = The Journal of Biological Chemistry | volume = 276 | issue = 24 | pages = 21434–42 | date = Jun 2001 | pmid = 11274175 | doi = 10.1074/jbc.M011423200 }}
*{{cite journal | author=Yu JX, Chao L, Chao J |title=Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. |journal=J. Biol. Chem. |volume=269 |issue= 29 |pages= 18843-8 |year= 1994 |pmid= 8034638 |doi=  }}
* {{cite journal | vauthors = Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE | title = Regulation of the epithelial sodium channel by serine proteases in human airways | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8338–45 | date = Mar 2002 | pmid = 11756432 | doi = 10.1074/jbc.M105044200 }}
*{{cite journal | author=Yu JX, Chao L, Ward DC, Chao J |title=Structure and chromosomal localization of the human prostasin (PRSS8) gene. |journal=Genomics |volume=32 |issue= 3 |pages= 334-40 |year= 1997 |pmid= 8838796 |doi= 10.1006/geno.1996.0127 }}
* {{cite journal | vauthors = Wang C, Chao J, Chao L | title = Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 284 | issue = 4 | pages = R1031-6 | date = Apr 2003 | pmid = 12626364 | doi = 10.1152/ajpregu.00660.2002 }}
*{{cite journal  | author=Nelson PS, Gan L, Ferguson C, ''et al.'' |title=Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 3114-9 |year= 1999 |pmid= 10077646 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Chen LM, Skinner ML, Kauffman SW, ''et al.'' |title=Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21434-42 |year= 2001 |pmid= 11274175 |doi= 10.1074/jbc.M011423200 }}
* {{cite journal | vauthors = Tong Z, Illek B, Bhagwandin VJ, Verghese GM, Caughey GH | title = Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 287 | issue = 5 | pages = L928-35 | date = Nov 2004 | pmid = 15246975 | doi = 10.1152/ajplung.00160.2004 }}
*{{cite journal | author=Donaldson SH, Hirsh A, Li DC, ''et al.'' |title=Regulation of the epithelial sodium channel by serine proteases in human airways. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8338-45 |year= 2002 |pmid= 11756432 |doi= 10.1074/jbc.M105044200 }}
* {{cite journal | vauthors = Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL | title = Biochemical characterization of prostasin, a channel activating protease | journal = Biochemical and Biophysical Research Communications | volume = 324 | issue = 2 | pages = 953–63 | date = Nov 2004 | pmid = 15474520 | doi = 10.1016/j.bbrc.2004.09.123 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Leyvraz C, Charles RP, Rubera I, Guitard M, Rotman S, Breiden B, Sandhoff K, Hummler E | title = The epidermal barrier function is dependent on the serine protease CAP1/Prss8 | journal = The Journal of Cell Biology | volume = 170 | issue = 3 | pages = 487–96 | date = Aug 2005 | pmid = 16061697 | pmc = 2171460 | doi = 10.1083/jcb.200501038 }}
*{{cite journal  | author=Wang C, Chao J, Chao L |title=Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=284 |issue= 4 |pages= R1031-6 |year= 2003 |pmid= 12626364 |doi= 10.1152/ajpregu.00660.2002 }}
* {{cite journal | vauthors = Fan B, Wu TD, Li W, Kirchhofer D | title = Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin | journal = The Journal of Biological Chemistry | volume = 280 | issue = 41 | pages = 34513–20 | date = Oct 2005 | pmid = 16103126 | doi = 10.1074/jbc.M502119200 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Chen M, Chen LM, Chai KX | title = Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG | journal = The Prostate | volume = 66 | issue = 9 | pages = 911–20 | date = Jun 2006 | pmid = 16541421 | doi = 10.1002/pros.20325 }}
*{{cite journal | author=Tong Z, Illek B, Bhagwandin VJ, ''et al.'' |title=Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=287 |issue= 5 |pages= L928-35 |year= 2004 |pmid= 15246975 |doi= 10.1152/ajplung.00160.2004 }}
* {{cite journal | vauthors = Rohan S, Tu JJ, Kao J, Mukherjee P, Campagne F, Zhou XK, Hyjek E, Alonso MA, Chen YT | title = Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes | journal = Clinical Cancer Research | volume = 12 | issue = 23 | pages = 6937–45 | date = Dec 2006 | pmid = 17145811 | doi = 10.1158/1078-0432.CCR-06-1268 }}
*{{cite journal | author=Shipway A, Danahay H, Williams JA, ''et al.'' |title=Biochemical characterization of prostasin, a channel activating protease. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 2 |pages= 953-63 |year= 2004 |pmid= 15474520 |doi= 10.1016/j.bbrc.2004.09.123 }}
* {{cite journal | vauthors = Chen M, Fu YY, Lin CY, Chen LM, Chai KX | title = Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3 | journal = Biochimica et Biophysica Acta | volume = 1773 | issue = 7 | pages = 1133–40 | date = Jul 2007 | pmid = 17532063 | pmc = 1950849 | doi = 10.1016/j.bbamcr.2007.04.013 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Leyvraz C, Charles RP, Rubera I, ''et al.'' |title=The epidermal barrier function is dependent on the serine protease CAP1/Prss8. |journal=J. Cell Biol. |volume=170 |issue= 3 |pages= 487-96 |year= 2005 |pmid= 16061697 |doi= 10.1083/jcb.200501038 }}
*{{cite journal | author=Fan B, Wu TD, Li W, Kirchhofer D |title=Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34513-20 |year= 2005 |pmid= 16103126 |doi= 10.1074/jbc.M502119200 }}
*{{cite journal | author=Chen M, Chen LM, Chai KX |title=Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. |journal=Prostate |volume=66 |issue= 9 |pages= 911-20 |year= 2006 |pmid= 16541421 |doi= 10.1002/pros.20325 }}
*{{cite journal | author=Rohan S, Tu JJ, Kao J, ''et al.'' |title=Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6937-45 |year= 2007 |pmid= 17145811 |doi= 10.1158/1078-0432.CCR-06-1268 }}
*{{cite journal | author=Chen M, Fu YY, Lin CY, ''et al.'' |title=Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3. |journal=Biochim. Biophys. Acta |volume=1773 |issue= 7 |pages= 1133-40 |year= 2007 |pmid= 17532063 |doi= 10.1016/j.bbamcr.2007.04.013 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Proteases}}
{{WikiDoc Sources}}
 
 
{{gene-16-stub}}

Latest revision as of 02:26, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Prostasin is a protein that in humans is encoded by the PRSS8 gene.[1][2][3]

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

The protein is implicated in epithelial sodium channel regulation[4] and may help regulate a variety of tissue functions that involve a sodium channel.[5]

References

  1. ↑ Yu JX, Chao L, Ward DC, Chao J (Mar 1996). "Structure and chromosomal localization of the human prostasin (PRSS8) gene". Genomics. 32 (3): 334–40. doi:10.1006/geno.1996.0127. PMID 8838796.
  2. ↑ Yu JX, Chao L, Chao J (Jun 1995). "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA". The Journal of Biological Chemistry. 270 (22): 13483–9. doi:10.1074/jbc.270.22.13483. PMID 7768952.
  3. ↑ "Entrez Gene: PRSS8 protease, serine, 8".
  4. ↑ Koda A, Wakida N, Toriyama K, Yamamoto K, Iijima H, Tomita K, Kitamura K (Apr 2009). "Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity". Hypertension Research. 32 (4): 276–81. doi:10.1038/hr.2009.6. PMID 19262497.
  5. ↑ Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y (Sep 2008). "Prostasin: a possible candidate gene for human hypertension". American Journal of Hypertension. 21 (9): 1028–33. doi:10.1038/ajh.2008.224. PMC 3812941. PMID 18583984.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PRSS8&oldid=1417399"