Staphylokinase (SAK) is a 136-amino acid enzyme from Staphylococcus aureus. It is positively regulated by the "agr" gene regulator. It activates plasminogen, which in turn can degrade various host proteins during infection.
This enzyme also seen with Streptococcus pyogenes (Group A beta hemolytic) noted for its role in the digestion of fibrin clots.
- Bokarewa MI, Jin T, Tarkowski A. (2006) Staphylococcus aureus: Staphylokinase Int J Biochem Cell Biol 38(4): 504-9
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