PRPF19: Difference between revisions

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{{Infobox_gene}}
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'''Pre-mRNA-processing factor 19''' is a [[protein]] that in humans is encoded by the ''PRPF19'' [[gene]].<ref name="pmid12960389">{{cite journal | author = Mahajan KN, Mitchell BS | title = Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 19 | pages = 10746–51 |date=September 2003 | pmid = 12960389 | pmc = 196874 | doi = 10.1073/pnas.1631060100 | bibcode = 2003PNAS..10010746M }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
| HGNCid = 17896
| Symbol = PRPF19
| AltSymbols =; NMP200; PRP19; PSO4; UBOX4; hPSO4
| OMIM = 608330
| ECnumber = 
| Homologene = 6421
| MGIid = 106247
| GeneAtlas_image1 = PBB_GE_PRPF19_203103_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27339
    | Hs_Ensembl = ENSG00000110107
    | Hs_RefseqProtein = NP_055317
    | Hs_RefseqmRNA = NM_014502
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 60414768
    | Hs_GenLoc_end = 60430623
    | Hs_Uniprot = Q9UMS4
    | Mm_EntrezGene = 28000
    | Mm_Ensembl = ENSMUSG00000024735
    | Mm_RefseqmRNA = XM_984379
    | Mm_RefseqProtein = XP_989473
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 10955201
    | Mm_GenLoc_end = 10972575
    | Mm_Uniprot = Q4ADG5
  }}
}}
'''PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)''', also known as '''PRPF19''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339| accessdate = }}</ref>
| summary_text = In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]<ref name="entrez" />
}}
}}
==Interactions==
PRPF19 has been shown to [[Protein-protein interaction|interact]] with [[CDC5L]].<ref name=pmid11101529>{{cite journal |last=Ajuh |first=P |authorlink= |author2=Kuster B |author3=Panov K |author4=Zomerdijk J C |author5=Mann M |author6=Lamond A I  |date=December 2000  |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305846 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Gerner C, Holzmann K, Meissner M, ''et al.'' |title=Reassembling proteins and chaperones in human nuclear matrix protein fractions. |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 145-51 |year= 1999 |pmid= 10404385 |doi=  }}
*{{cite journal   |vauthors=Gerner C, Holzmann K, Meissner M, etal |title=Reassembling proteins and chaperones in human nuclear matrix protein fractions. |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 145–51 |year= 1999 |pmid= 10404385 |doi=10.1002/(SICI)1097-4644(19990801)74:2<145::AID-JCB1>3.0.CO;2-# }}
*{{cite journal | author=Gotzmann J, Gerner C, Meissner M, ''et al.'' |title=hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 166-79 |year= 2000 |pmid= 11082287 |doi= 10.1006/excr.2000.5025 }}
*{{cite journal   |vauthors=Gotzmann J, Gerner C, Meissner M, etal |title=hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 166–79 |year= 2000 |pmid= 11082287 |doi= 10.1006/excr.2000.5025 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal   |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Mahajan KN, Mitchell BS |title=Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10746-51 |year= 2003 |pmid= 12960389 |doi= 10.1073/pnas.1631060100 }}
*{{cite journal   |vauthors=Makarova OV, Makarov EM, Urlaub H, etal |title=A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. |journal=EMBO J. |volume=23 |issue= 12 |pages= 2381–91 |year= 2004 |pmid= 15175653 |doi= 10.1038/sj.emboj.7600241  | pmc=423283 }}
*{{cite journal | author=Makarova OV, Makarov EM, Urlaub H, ''et al.'' |title=A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. |journal=EMBO J. |volume=23 |issue= 12 |pages= 2381-91 |year= 2004 |pmid= 15175653 |doi= 10.1038/sj.emboj.7600241 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Löscher M, Fortschegger K, Ritter G, etal |title=Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 593–603 |year= 2005 |pmid= 15660529 |doi= 10.1042/BJ20041517  | pmc=1138967 }}
*{{cite journal | author=Löscher M, Fortschegger K, Ritter G, ''et al.'' |title=Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 593-603 |year= 2005 |pmid= 15660529 |doi= 10.1042/BJ20041517 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Zhang N, Kaur R, Lu X, etal |title=The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40559–67 |year= 2006 |pmid= 16223718 |doi= 10.1074/jbc.M508453200 }}
*{{cite journal | author=Zhang N, Kaur R, Lu X, ''et al.'' |title=The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40559-67 |year= 2006 |pmid= 16223718 |doi= 10.1074/jbc.M508453200 }}
*{{cite journal   |vauthors=Grillari J, Ajuh P, Stadler G, etal |title=SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. |journal=Nucleic Acids Res. |volume=33 |issue= 21 |pages= 6868–83 |year= 2005 |pmid= 16332694 |doi= 10.1093/nar/gki986  | pmc=1310963 }}
*{{cite journal | author=Grillari J, Ajuh P, Stadler G, ''et al.'' |title=SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. |journal=Nucleic Acids Res. |volume=33 |issue= 21 |pages= 6868-83 |year= 2005 |pmid= 16332694 |doi= 10.1093/nar/gki986 }}
*{{cite journal   |vauthors=Voglauer R, Chang MW, Dampier B, etal |title=SNEV overexpression extends the life span of human endothelial cells. |journal=Exp. Cell Res. |volume=312 |issue= 6 |pages= 746–59 |year= 2006 |pmid= 16388800 |doi= 10.1016/j.yexcr.2005.11.025 }}
*{{cite journal  | author=Voglauer R, Chang MW, Dampier B, ''et al.'' |title=SNEV overexpression extends the life span of human endothelial cells. |journal=Exp. Cell Res. |volume=312 |issue= 6 |pages= 746-59 |year= 2006 |pmid= 16388800 |doi= 10.1016/j.yexcr.2005.11.025 }}
*{{cite journal  | author=Lu X, Legerski RJ |title=The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage. |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 4 |pages= 968–74 |year= 2007 |pmid= 17276391 |doi= 10.1016/j.bbrc.2007.01.097  | pmc=1810354 }}
*{{cite journal | author=Lu X, Legerski RJ |title=The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage. |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 4 |pages= 968-74 |year= 2007 |pmid= 17276391 |doi= 10.1016/j.bbrc.2007.01.097 }}
*{{cite journal   |vauthors=Fortschegger K, Wagner B, Voglauer R, etal |title=Early embryonic lethality of mice lacking the essential protein SNEV. |journal=Mol. Cell. Biol. |volume=27 |issue= 8 |pages= 3123–30 |year= 2007 |pmid= 17283042 |doi= 10.1128/MCB.01188-06  | pmc=1899945 }}
*{{cite journal | author=Fortschegger K, Wagner B, Voglauer R, ''et al.'' |title=Early embryonic lethality of mice lacking the essential protein SNEV. |journal=Mol. Cell. Biol. |volume=27 |issue= 8 |pages= 3123-30 |year= 2007 |pmid= 17283042 |doi= 10.1128/MCB.01188-06 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 19:52, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.[1][2]

In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM][2]

Interactions

PRPF19 has been shown to interact with CDC5L.[3]

References

  1. ↑ Mahajan KN, Mitchell BS (September 2003). "Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase". Proc Natl Acad Sci U S A. 100 (19): 10746–51. Bibcode:2003PNAS..10010746M. doi:10.1073/pnas.1631060100. PMC 196874. PMID 12960389.
  2. ↑ 2.0 2.1 "Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)".
  3. ↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading



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