Polynucleotide adenylyltransferase

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In enzymology, a polynucleotide adenylyltransferase (EC is an enzyme that catalyzes the chemical reaction

ATP + RNAn diphosphate + RNAn+1

Thus, the two substrates of this enzyme are ATP and RNAn, whereas its two products are diphosphate and RNAn+1.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:polynucleotide adenylyltransferase. Other names in common use include NTP polymerase, RNA adenylating enzyme, AMP polynucleotidylexotransferase, ATP-polynucleotide adenylyltransferase, ATP:polynucleotidylexotransferase, poly(A) polymerase, poly(A) synthetase, polyadenylate nucleotidyltransferase, polyadenylate polymerase, polyadenylate synthetase, polyadenylic acid polymerase, polyadenylic polymerase, terminal riboadenylate transferase, poly(A) hydrolase, RNA formation factors, PF1, and adenosine triphosphate:ribonucleic acid adenylyltransferase.

Structural studies

As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes 1AV6, 1B42, 1BKY, 1EAM, 1EQA, 1F5A, 1FA0, 1JSZ, 1JTE, 1JTF, 1P39, 1Q78, 1Q79, 1V39, 1VFG, 1VP3, 1VP9, 1VPT, 2GA9, 2GAF, 2HHP, 2O1P, 2Q66, 2VP3, 3MAG, 3MCT, and 4DCG.


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  • AUGUST JT, ORTIZ PJ, HURWITZ J (1962). "Ribonucleic acid-dependent ribonucleotide incorporation. I Purification and properties of the enzyme". J. Biol. Chem. 237: 3786&ndash, 93. PMID 13965521.
  • Edmonds M and Abrams R (1960). "Polynucleotide biosynthesis: formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei". J. Biol. Chem. 235: 1142&ndash, 1149.
  • Gottesman ME, Canellakis ES (1966). "The terminal nucleotidyltransferases of calf thymus nuclei". J. Biol. Chem. 241: 4339&ndash, 52. PMID 4288534.
  • KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES (1962). "Studies on the incorporation of deoxyribonucleic acid". Biochim. Biophys. Acta. 55: 639&ndash, 50. PMID 14459258.
  • Mans RJ, Walter TJ (1971). "Transfer RNA-primed oligoadenylate synthesis in maize seedlings. II Primer, substrate and metal specificities and size of product". Biochim. Biophys. Acta. 247: 113&ndash, 21. PMID 4946277.
  • Sheldon R, Jurale C, Kates J (1972). "Detection of polyadenylic acid sequences in viral and eukaryotic RNA(polu(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4)". Proc. Natl. Acad. Sci. U. S. A. 69: 417&ndash, 21. PMID 4501121.

External links

The CAS registry number for this enzyme class is 9026-30-6.

Gene Ontology (GO) codes