PPP2R2B: Difference between revisions

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{{Infobox_gene}}
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'''Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform''' is an [[enzyme]] that in humans is encoded by the ''PPP2R2B'' [[gene]].<ref name="pmid1849734">{{cite journal | vauthors = Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA | title = Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform | journal = Biochemistry | volume = 30 | issue = 15 | pages = 3589–97 |date=May 1991 | pmid = 1849734 | pmc = | doi =10.1021/bi00229a001  }}</ref><ref name="pmid10581021">{{cite journal | vauthors = Holmes SE, O'Hearn EE, McInnis MG, Gorelick-Feldman DA, Kleiderlein JJ, Callahan C, Kwak NG, Ingersoll-Ashworth RG, Sherr M, Sumner AJ, Sharp AH, Ananth U, Seltzer WK, Boss MA, Vieria-Saecker AM, Epplen JT, Riess O, Ross CA, Margolis RL | title = Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12 | journal = Nat Genet | volume = 23 | issue = 4 | pages = 391–2 |date=Dec 1999 | pmid = 10581021 | pmc =  | doi = 10.1038/70493 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
| HGNCid = 9305
| Symbol = PPP2R2B
| AltSymbols =; MGC24888; PP2A-PR55B; PR2AB-BETA; PR2AB55-BETA; PR2APR55-BETA; PR52B; PR55-BETA; SCA12
| OMIM = 604325
| ECnumber = 
| Homologene = 55833
| MGIid = 1920180
| GeneAtlas_image1 = PBB_GE_PPP2R2B_213849_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP2R2B_205643_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}}
| Component = {{GNF_GO|id=GO:0000159 |text = protein phosphatase type 2A complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008219 |text = cell death}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5521
    | Hs_Ensembl = ENSG00000156475
    | Hs_RefseqProtein = NP_004567
    | Hs_RefseqmRNA = NM_004576
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 145949265
    | Hs_GenLoc_end = 146415783
    | Hs_Uniprot = Q00005
    | Mm_EntrezGene = 72930
    | Mm_Ensembl = ENSMUSG00000024500
    | Mm_RefseqmRNA = NM_027531
    | Mm_RefseqProtein = NP_081807
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 42763405
    | Mm_GenLoc_end = 43184571
    | Mm_Uniprot = Q9D3B7
  }}
}}
'''Protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform''', also known as '''PPP2R2B''', is a human [[gene]].


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =
| summary_text = The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5521| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major [[Serine|Ser]]/[[Threonine|Thr]] phosphatases, and it is implicated in the negative control of [[cell growth]] and [[Cell division|division]]. It consists of a common [[heteromeric]] core enzyme, which is composed of a [[catalytic]] subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate [[substrate (biochemistry)|substrate]] selectivity and catalytic activity. This gene encodes a beta [[isoform]] of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of [[autosomal dominant]] [[Spinocerebellar ataxia|spinocerebellar ataxia 12]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5521| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Millward TA, Zolnierowicz S, Hemmings BA |title=Regulation of protein kinase cascades by protein phosphatase 2A. |journal=Trends Biochem. Sci. |volume=24 |issue= 5 |pages= 186-91 |year= 1999 |pmid= 10322434 |doi=  }}
*{{cite journal  | vauthors=Millward TA, Zolnierowicz S, Hemmings BA |title=Regulation of protein kinase cascades by protein phosphatase 2A. |journal=Trends Biochem. Sci. |volume=24 |issue= 5 |pages= 186–91 |year= 1999 |pmid= 10322434 |doi=10.1016/S0968-0004(99)01375-4 }}
*{{cite journal  | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43-51 |year= 2005 |pmid= 15638722 |doi=  }}
*{{cite journal  | vauthors=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=10.2174/1570162052772988 }}
*{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
*{{cite journal  | vauthors=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 }}
*{{cite journal  | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal  | vauthors=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal  | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi=  }}
*{{cite journal  | vauthors=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=  }}
*{{cite journal  | author=Mayer RE, Hendrix P, Cron P, ''et al.'' |title=Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. |journal=Biochemistry |volume=30 |issue= 15 |pages= 3589-97 |year= 1991 |pmid= 1849734 |doi=  }}
*{{cite journal  | vauthors=Schalling M, Hudson TJ, Buetow KH, Housman DE |title=Direct detection of novel expanded trinucleotide repeats in the human genome. |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 135–9 |year= 1993 |pmid= 8348150 |doi= 10.1038/ng0693-135 }}
*{{cite journal  | author=Schalling M, Hudson TJ, Buetow KH, Housman DE |title=Direct detection of novel expanded trinucleotide repeats in the human genome. |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 135-9 |year= 1993 |pmid= 8348150 |doi= 10.1038/ng0693-135 }}
*{{cite journal   |vauthors=Tung HY, De Rocquigny H, Zhao LJ, etal |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2–3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=10.1016/S0014-5793(96)01470-6 }}
*{{cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, ''et al.'' |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197-201 |year= 1997 |pmid= 9013886 |doi=  }}
*{{cite journal  | vauthors=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
*{{cite journal  | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432-43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
*{{cite journal   |vauthors=Strack S, Zaucha JA, Ebner FF, etal |title=Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits |journal=J. Comp. Neurol. |volume=392 |issue= 4 |pages= 515–27 |year= 1998 |pmid= 9514514 |doi=10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3  }}
*{{cite journal | author=Strack S, Zaucha JA, Ebner FF, ''et al.'' |title=Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. |journal=J. Comp. Neurol. |volume=392 |issue= 4 |pages= 515-27 |year= 1998 |pmid= 9514514 |doi=  }}
*{{cite journal   |vauthors=Fujigasaki H, Verma IC, Camuzat A, etal |title=SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family |journal=Ann. Neurol. |volume=49 |issue= 1 |pages= 117–21 |year= 2001 |pmid= 11198281 |doi=10.1002/1531-8249(200101)49:1<117::AID-ANA19>3.0.CO;2-G }}
*{{cite journal  | author=Holmes SE, O'Hearn EE, McInnis MG, ''et al.'' |title=Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 391-2 |year= 1999 |pmid= 10581021 |doi= 10.1038/70493 }}
*{{cite journal   |vauthors=Elder RT, Yu M, Chen M, etal |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
*{{cite journal  | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956-67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956 }}
*{{cite journal  | vauthors=Guo CY, Brautigan DL, Larner JM |title=ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4839–44 |year= 2002 |pmid= 11723136 |doi= 10.1074/jbc.M110092200 }}
*{{cite journal | author=Fujigasaki H, Verma IC, Camuzat A, ''et al.'' |title=SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family. |journal=Ann. Neurol. |volume=49 |issue= 1 |pages= 117-21 |year= 2001 |pmid= 11198281 |doi=  }}
*{{cite journal   |vauthors=Bennin DA, Don AS, Brake T, etal |title=Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27449–67 |year= 2002 |pmid= 11956189 |doi= 10.1074/jbc.M111693200 }}
*{{cite journal | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359-70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
*{{cite journal   |vauthors=Okamoto K, Li H, Jensen MR, etal |title=Cyclin G recruits PP2A to dephosphorylate Mdm2 |journal=Mol. Cell |volume=9 |issue= 4 |pages= 761–71 |year= 2002 |pmid= 11983168 |doi=10.1016/S1097-2765(02)00504-X }}
*{{cite journal  | author=Guo CY, Brautigan DL, Larner JM |title=ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4839-44 |year= 2002 |pmid= 11723136 |doi= 10.1074/jbc.M110092200 }}
*{{cite journal   |vauthors=Marmorstein LY, McLaughlin PJ, Stanton JB, etal |title=Bestrophin interacts physically and functionally with protein phosphatase 2A |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30591–7 |year= 2002 |pmid= 12058047 |doi= 10.1074/jbc.M204269200 }}
*{{cite journal | author=Bennin DA, Don AS, Brake T, ''et al.'' |title=Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27449-67 |year= 2002 |pmid= 11956189 |doi= 10.1074/jbc.M111693200 }}
*{{cite journal  | vauthors=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420 | pmc=126131 }}
*{{cite journal | author=Okamoto K, Li H, Jensen MR, ''et al.'' |title=Cyclin G recruits PP2A to dephosphorylate Mdm2. |journal=Mol. Cell |volume=9 |issue= 4 |pages= 761-71 |year= 2002 |pmid= 11983168 |doi=  }}
*{{cite journal | author=Marmorstein LY, McLaughlin PJ, Stanton JB, ''et al.'' |title=Bestrophin interacts physically and functionally with protein phosphatase 2A. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30591-7 |year= 2002 |pmid= 12058047 |doi= 10.1074/jbc.M204269200 }}
*{{cite journal  | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420 }}
}}
}}
{{refend}}
{{refend}}


{{gene-5-stub}}
==External links==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sca12  GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 12]
 
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{{Gene-5-stub}}

Latest revision as of 18:35, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.[1][2]

The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.[3]

References

  1. ↑ Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (May 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.
  2. ↑ Holmes SE, O'Hearn EE, McInnis MG, Gorelick-Feldman DA, Kleiderlein JJ, Callahan C, Kwak NG, Ingersoll-Ashworth RG, Sherr M, Sumner AJ, Sharp AH, Ananth U, Seltzer WK, Boss MA, Vieria-Saecker AM, Epplen JT, Riess O, Ross CA, Margolis RL (Dec 1999). "Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12". Nat Genet. 23 (4): 391–2. doi:10.1038/70493. PMID 10581021.
  3. ↑ "Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform".

Further reading

External links



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