POEMS syndrome physical examination: Difference between revisions

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{{POEMS syndrome}}
{{POEMS syndrome}}
{{CMG}} {{AE}} {{HK}}
{{CMG}} {{AE}} {{HK}}{{Sab}}


== Overview ==
== Overview ==
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===Appearance===
===Appearance===
* [[Anasarca]] or [[ascites]] may be present.
* [[Anasarca]] or [[ascites]] may be present.
===Vital Signs===
* Vital signs of [[Patient|patients]] with POEMS syndrome are usually normal.
===Skin===
===Skin===
* [[Hyperpigmentation]]
 
* [[Nail clubbing]]
*[[Hyperpigmentation]]
* [[Leuconychia]]
*[[Nail clubbing]]
* Thickening of the skin
*[[Leuconychia]]
* Thickening of the skin<ref name="pmid25888197">{{cite journal |vauthors=Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK |title=POEMS syndrome with peripheral and central nervous system demyelination: case report |journal=Neurologist |volume=19 |issue=4 |pages=101–3 |date=April 2015 |pmid=25888197 |doi=10.1097/NRL.0000000000000017 |url=}}</ref>
* Excess hair or hair in unusual places ([[hypertrichosis]])
* Excess hair or hair in unusual places ([[hypertrichosis]])
* Skin [[angioma]]s or [[haemangioma]]s
* Skin [[angioma]]s or [[haemangioma]]s<ref name="pmid25888197">{{cite journal |vauthors=Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK |title=POEMS syndrome with peripheral and central nervous system demyelination: case report |journal=Neurologist |volume=19 |issue=4 |pages=101–3 |date=April 2015 |pmid=25888197 |doi=10.1097/NRL.0000000000000017 |url=}}</ref>
* There may be changes reminiscent of [[scleroderma]]
* There may be changes reminiscent of [[scleroderma]]


===Eye===
===HEENT===
* [[Papilloedema]]
 
* [[Papilledema]]
* [[Uveitis]] and [[preretinal haemorrhage]] may be present.
* [[Uveitis]] and [[preretinal haemorrhage]] may be present.


===Abdomen===
=== Neck ===
 
* [[Lymphadenopathy]]
 
=== Lungs ===
 
* [[Pleural effusion]] (decreased or absent breath sounds, decreased [[tactile fremitus]], dullness to [[percussion]])
 
=== Heart ===
 
* [[Pericardial effusion]] ([[muffled heart sounds]], [[jugular venous distension]])
 
=== Abdomen ===
 
* [[Hepatomegaly]]
* [[Hepatomegaly]]
* [[Splenomegaly]]
* [[Splenomegaly]]
* [[Ascites]] (succession splash, [[shifting dullness]])
* [[Ascites]] (succession splash, [[shifting dullness]])


=== Cardiovascular ===
=== Back ===
* [[Pericardial effusion]] ([[muffled heart sounds]], [[jugular venous distension]])
 
* Back [[Physical examination|examination]] of [[Patient|patients]] with POEMS syndrome is usually normal.
 
=== Genitourinary ===


=== Respiratory ===
* [[Genitourinary system|Genitourinary]] [[Physical examination|examination]] of [[patients]] with POEMS syndrome is usually normal.
* [[Pleural effusion]] (decreased or absent breath sounds, decreased [[tactile fremitus]], dullness to [[percussion]])


=== Musculoskeletal ===
=== Neuromuscular ===
* [[Bones]] may have sclerotic, lytic with sclerotic rims or mixed sclerotic/lytic lesions with soup-bubble appearance
* Symmetrical, ascending chronic progressive [[polyneuropathy]] with both [[Sensory system|sensory]] (pin-prick and vibration) and motor disability (motor > sensory)
*Decreased muscle strength<ref name="pmid25888197">{{cite journal |vauthors=Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK |title=POEMS syndrome with peripheral and central nervous system demyelination: case report |journal=Neurologist |volume=19 |issue=4 |pages=101–3 |date=April 2015 |pmid=25888197 |doi=10.1097/NRL.0000000000000017 |url=}}</ref>
*Absent deep tendon reflexes<ref name="pmid25888197">{{cite journal |vauthors=Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK |title=POEMS syndrome with peripheral and central nervous system demyelination: case report |journal=Neurologist |volume=19 |issue=4 |pages=101–3 |date=April 2015 |pmid=25888197 |doi=10.1097/NRL.0000000000000017 |url=}}</ref>
*Impaired temperature, position, and vibration senses<ref name="pmid25888197">{{cite journal |vauthors=Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK |title=POEMS syndrome with peripheral and central nervous system demyelination: case report |journal=Neurologist |volume=19 |issue=4 |pages=101–3 |date=April 2015 |pmid=25888197 |doi=10.1097/NRL.0000000000000017 |url=}}</ref>


=== Miscellaneous ===
=== Extremities ===
* [[Lymphadenopathy]]
* [[Bones]] may have [[Sclerosis|sclerotic]], [[lytic]] with [[Sclerosis|sclerotic]] rims or mixed [[Sclerosis|sclerotic]]/[[lytic]] [[lesions]] with soap-bubble appearance.


==References==
==References==

Latest revision as of 14:10, 9 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]

Overview

Common physical examination findings of POEMS syndrome include, organomegaly (hepatomegaly, splenomegaly), peripheral edema/anasarca, ascites, mixed lytic/sclerotic bone lesions, papilledema, skin hyperpigmentation and lymphadenopathy.

Physical Examination

Appearance

Vital Signs

  • Vital signs of patients with POEMS syndrome are usually normal.

Skin

HEENT

Neck

Lungs

Heart

Abdomen

Back

Genitourinary

Neuromuscular

  • Symmetrical, ascending chronic progressive polyneuropathy with both sensory (pin-prick and vibration) and motor disability (motor > sensory)
  • Decreased muscle strength[1]
  • Absent deep tendon reflexes[1]
  • Impaired temperature, position, and vibration senses[1]

Extremities

References

  1. 1.0 1.1 1.2 1.3 1.4 Güneş HN, Bilecenoğlu NT, Şener U, Yoldaş TK (April 2015). "POEMS syndrome with peripheral and central nervous system demyelination: case report". Neurologist. 19 (4): 101–3. doi:10.1097/NRL.0000000000000017. PMID 25888197.

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