Ovarian cancer natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(5 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Ovarian cancer}}
{{Ovarian cancer}}
{{CMG}}
{{CMG}}; {{AE}} {{Hudakarman}}
==Overview==
[[Ovarian cancer]] is often diagnosed late resulting in a poor overall outcome for the patient. Ovarian cancer complications can be spread of cancer to other organs, progressive function loss of various organs, ascites (fluid in the abdomen), intestinal obstruction. Ovarian cancer has a poor [[prognosis]]. More than 60% of patients presenting with this cancer already have stage III or stage IV cancer, when it has already spread beyond the ovaries.
==Natural History, Complications, and Prognosis==


==Overview==
===Natural History===
Ovarian cancer is often diagnosed late resulting in a poor overall outcome for the patient.
*[[Ovarian cancer]] is often diagnosed late resulting in a poor overall outcome for the patient.


==Complications==
===Complications===
*Spread of the cancer to other organs
*Spread of [[ovarian cancer]] to other organs
*Progressive function loss of various organs
*Progressive function loss of various organs
*Ascites (fluid in the abdomen)
*[[Ascites]] (fluid in the abdomen)
*Intestinal obstruction
*[[Intestinal obstruction]]
 
==Prognosis==
Ovarian cancer has a poor [[prognosis]]. It is disproportionately deadly because symptoms are vague and non-specific, hence diagnosis is late. More than 60% of patients presenting with this cancer already have stage III or stage IV cancer, when it has already spread beyond the ovaries.
 
Ovarian cancers that are [[malignant]] shed cells into the naturally occurring fluid within the abdominal cavity.  These cells can implant on other abdominal (peritoneal) structures included the [[uterus]], [[urinary bladder]], [[bowel]], lining of the bowel wall ([[omentum]]) and can even spread to the [[lungs]]. These cells can begin forming new tumor growths before cancer is even suspected.
 
More than 50% of women with ovarian cancer are diagnosed in the advanced stages of the disease because no cost-effective screening test for ovarian cancer exists. The [[five year survival rate]] for all stages is only 35% to 38%. If, however, diagnosis is made early in the disease, five-year survival rates can reach 90% to 98%.
 
[[Germ cell tumor]]s of the ovary have a much better prognosis than other ovarian cancers, in part because they tend to grow rapidly to a very large size, hence they are detected sooner.


===Prognosis===
*[[Ovarian cancer]] has a poor [[prognosis]]. It is disproportionately deadly because symptoms are vague and non-specific, hence diagnosis is late. More than 60% of patients presenting with this cancer already have stage III or stage IV cancer, when it has already [[Spread of the cancer|spread]] beyond the [[ovaries]].
* Ovarian cancers that are [[malignant]] shed cells into the naturally occurring fluid within the abdominal cavity.  These cells can implant on other abdominal (peritoneal) structures included the [[uterus]], [[urinary bladder]], [[bowel]], lining of the bowel wall ([[omentum]]) and can even spread to the [[lungs]]. These cells can begin forming new tumor growths before cancer is even suspected.
* More than 50% of women with ovarian cancer are diagnosed in the advanced stages of the disease because no cost-effective screening test for ovarian cancer exists.
* The [[five year survival rate]] for all stages is only 35% to 38%. If, however, diagnosis is made early in the disease, five-year survival rates can reach 90% to 98%.
* [[Germ cell tumor]]s of the ovary have a much better prognosis than other ovarian cancers, in part because they tend to grow rapidly to a very large size, hence they are detected sooner.
===5-Year Survival===
===5-Year Survival===


Line 33: Line 33:
|style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Stage'''|| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | '''5-year relative survival (%), (2004-2010)'''
|style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Stage'''|| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | '''5-year relative survival (%), (2004-2010)'''
|-
|-
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''All stages'''|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |44.5%
! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" |'''All stages'''
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" |44.5%
|-
|-
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''Localized'''|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left  |92.3%
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''Localized'''|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left  |92.3%
Line 44: Line 45:
|}
|}


* Shown below is an image depicting the 5-year conditional relative survival (probability of surviving in the next 5-years given the cohort has already survived 0, 1, 3 years) between 1998 and 2010 of ovarian cancer by stage at diagnosis according to [[SEER]]. These graphs are adapted from [[SEER]]: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
* Shown below is an image depicting the 5-year conditional relative survival (probability of surviving in the next 5-years given the cohort has already survived 0, 1, 3 years) between 1998 and 2010 of ovarian cancer by stage at diagnosis according to [[SEER]].  
*These graphs are adapted from [[SEER]]: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>


[[Image:5-year survival in ovarian cancer in USA.png|5-year conditional relative survival (probability of surviving in the next 5-years given the cohort has already survived 0, 1, 3 years) between 1998 and 2010 of ovarian cancer by stage at diagnosis according to SEER]]
[[Image:5-year survival in ovarian cancer in USA.png|5-year conditional relative survival (probability of surviving in the next 5-years given the cohort has already survived 0, 1, 3 years) between 1998 and 2010 of ovarian cancer by stage at diagnosis according to SEER]]

Latest revision as of 19:23, 14 October 2019

Ovarian cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classifications

Pathophysiology

Causes of Ovarian cancer

Differentiating Ovarian cancer from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms

Physical Examination

Staging

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian cancer natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian cancer natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian cancer natural history, complications and prognosis

CDC on Ovarian cancer natural history, complications and prognosis

Ovarian cancer natural history, complications and prognosis in the news

Blogs on Ovarian cancer natural history, complications and prognosis

Directions to Hospitals Treating Ovarian cancer

Risk calculators and risk factors for Ovarian cancer natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.

Overview

Ovarian cancer is often diagnosed late resulting in a poor overall outcome for the patient. Ovarian cancer complications can be spread of cancer to other organs, progressive function loss of various organs, ascites (fluid in the abdomen), intestinal obstruction. Ovarian cancer has a poor prognosis. More than 60% of patients presenting with this cancer already have stage III or stage IV cancer, when it has already spread beyond the ovaries.

Natural History, Complications, and Prognosis

Natural History

  • Ovarian cancer is often diagnosed late resulting in a poor overall outcome for the patient.

Complications

Prognosis

  • Ovarian cancer has a poor prognosis. It is disproportionately deadly because symptoms are vague and non-specific, hence diagnosis is late. More than 60% of patients presenting with this cancer already have stage III or stage IV cancer, when it has already spread beyond the ovaries.
  • Ovarian cancers that are malignant shed cells into the naturally occurring fluid within the abdominal cavity. These cells can implant on other abdominal (peritoneal) structures included the uterus, urinary bladder, bowel, lining of the bowel wall (omentum) and can even spread to the lungs. These cells can begin forming new tumor growths before cancer is even suspected.
  • More than 50% of women with ovarian cancer are diagnosed in the advanced stages of the disease because no cost-effective screening test for ovarian cancer exists.
  • The five year survival rate for all stages is only 35% to 38%. If, however, diagnosis is made early in the disease, five-year survival rates can reach 90% to 98%.
  • Germ cell tumors of the ovary have a much better prognosis than other ovarian cancers, in part because they tend to grow rapidly to a very large size, hence they are detected sooner.

5-Year Survival

  • Between 2004 and 2010, the 5-year relative survival of patients with ovarian cancer was 44.6%.[1]
  • When stratified by age, the 5-year relative survival of patients with ovarian cancer was 57.5% and 27.3% for patients <65 and ≥ 65 years of age respectively.[1]
  • The survival of patients with ovarian cancer varies with the stage of the disease. Shown below is a table depicting the 5-year relative survival by the stage of ovarian cancer:[1]
Stage 5-year relative survival (%), (2004-2010)
All stages 44.5%
Localized 92.3%
Regional 71.7%
Distant 27.4%
Unstaged 21.7%
  • Shown below is an image depicting the 5-year conditional relative survival (probability of surviving in the next 5-years given the cohort has already survived 0, 1, 3 years) between 1998 and 2010 of ovarian cancer by stage at diagnosis according to SEER.
  • These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[1]

5-year conditional relative survival (probability of surviving in the next 5-years given the cohort has already survived 0, 1, 3 years) between 1998 and 2010 of ovarian cancer by stage at diagnosis according to SEER

References

  1. 1.0 1.1 1.2 1.3 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.


Template:WikiDoc Sources