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{{Osteoporosis}}
{{Osteoporosis}}
{{CMG}}
{{CMG}}; '''Associate Editor(s)-In-Chief:''' {{CZ}}, [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]][mailto:ravitheja.g@gmail.com]  
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'''Associate Editor(s)-In-Chief:''' {{CZ}}, [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]][mailto:rgudetti@perfuse.org]  


==Overview==
==Overview==
[[Osteoporosis]] is defined as the disease state with T-score less than -2.5 for decreased [[Bone mineral density]] on a [[DEXA scan]]. Osteoporosis may be primary (without any underlying cause) or secondary (having an underlying cause).
[[Osteoporosis]] is defined as a disease state with a T-score of less than -2.5 for decreased [[bone mineral density]] on a [[DEXA scan]]. Osteoporosis may be primary (without any underlying cause) or secondary (having an underlying cause).


==Classification==
==Classification==
There are three types into which [[osteoporosis]] is sub-divided. They are:
* Involutional Osteoporosis - otherwise called primary osteoporosis. No underlying cause is identified.
* Secondary osteoporosis in which the underlying cause (eg, steroid use) is known.
* Rare forms of the disease, such as juvenile, pregnancy-related, and postpartum osteoporosis.
There is a spectrum of disease ranging from osteopenia (milder and earlier bone loss) to osteoporosis (later more severe bone loss).
There is a spectrum of disease ranging from osteopenia (milder and earlier bone loss) to osteoporosis (later more severe bone loss).
===Osteopenia===
===Osteopenia===
'''Osteopenia''' which is defined as [[bone mineral density]] ranging from less than -1.0 and more than -2.5,  can be a precursor condition to [[osteoporosis]].<ref name="WHOcriteria">{{cite web |author=WHO Scientific Group on the Prevention and Management of Osteoporosis (2000 : Geneva, Switzerland)|url=http://whqlibdoc.who.int/trs/WHO_TRS_921.pdf |title=Prevention and management of osteoporosis : report of a WHO scientific group|year=2003 |accessdate=2007-05-31 |format=pdf |work=}}</ref>
'''Osteopenia''' which is defined as [[bone mineral density]] ranging from less than -1.0 and more than -2.5,  can be a precursor condition to [[osteoporosis]].<ref name="WHOcriteria">{{cite web |author=WHO Scientific Group on the Prevention and Management of Osteoporosis (2000 : Geneva, Switzerland)|url=http://whqlibdoc.who.int/trs/WHO_TRS_921.pdf |title=Prevention and management of osteoporosis : report of a WHO scientific group|year=2003 |accessdate=2007-05-31 |format=pdf |work=}}</ref>
===Osteoporosis===
===Osteoporosis===
In osteoporosis the [[bone mineral density]] (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of non-[[collagen]]ous proteins in bone is altered. Osteoporosis is defined by the [[World Health Organization]] (WHO) in women as a bone mineral density 2.5 [[standard deviation]]s below peak bone mass (20-year-old sex-matched healthy person average) as measured by [[Dual energy X-ray absorptiometry|DXA]]; the term "established osteoporosis" includes the presence of a [[fragility fracture]].<ref name=WHO1994>{{cite journal |author=WHO |title=Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group |journal=World Health Organization technical report series |volume=843|issue= |pages=1–129 |year=1994 |pmid=7941614 |doi=}}</ref> Osteoporosis is most common in women after the [[menopause]], when it is called '''postmenopausal osteoporosis''', but may develop in men and premenopausal women in the presence of particular hormonal disorders and other [[Chronic (medicine)|chronic]] diseases or as a result of [[tobacco smoking|smoking]] and[[medications]], specifically [[glucocorticoid]]s, when the disease is called '''steroid-''' or '''glucocorticoid-induced osteoporosis''' (SIOP or GIOP).
In osteoporosis the [[bone mineral density]] (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of non-[[collagen]]ous proteins in bone is altered. Osteoporosis is defined by the [[World Health Organization]] (WHO) in women as a bone mineral density 2.5 [[standard deviation]]s below peak bone mass (20-year-old sex-matched healthy person average) as measured by [[Dual energy X-ray absorptiometry|DXA]]; the term "established osteoporosis" includes the presence of a [[fragility fracture]].<ref name=WHO1994>{{cite journal |author=WHO |title=Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group |journal=World Health Organization technical report series |volume=843|issue= |pages=1–129 |year=1994 |pmid=7941614 |doi=}}</ref>
It is also a sign of normal [[aging]], in contrast to [[osteoporosis]] which is present in pathologic aging.
 
 


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Grammar]]




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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Raviteja Guddeti, M.B.B.S.[3]

Overview

Osteoporosis is defined as a disease state with a T-score of less than -2.5 for decreased bone mineral density on a DEXA scan. Osteoporosis may be primary (without any underlying cause) or secondary (having an underlying cause).

Classification

There are three types into which osteoporosis is sub-divided. They are:

  • Involutional Osteoporosis - otherwise called primary osteoporosis. No underlying cause is identified.
  • Secondary osteoporosis in which the underlying cause (eg, steroid use) is known.
  • Rare forms of the disease, such as juvenile, pregnancy-related, and postpartum osteoporosis.

There is a spectrum of disease ranging from osteopenia (milder and earlier bone loss) to osteoporosis (later more severe bone loss).

Osteopenia

Osteopenia which is defined as bone mineral density ranging from less than -1.0 and more than -2.5, can be a precursor condition to osteoporosis.[1]

Osteoporosis

In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of non-collagenous proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old sex-matched healthy person average) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.[2]

References

  1. WHO Scientific Group on the Prevention and Management of Osteoporosis (2000 : Geneva, Switzerland) (2003). "Prevention and management of osteoporosis : report of a WHO scientific group" (pdf). Retrieved 2007-05-31.
  2. WHO (1994). "Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group". World Health Organization technical report series. 843: 1–129. PMID 7941614.


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