Oral cancer causes: Difference between revisions
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{{CMG}}:{{AE}};{{SSW}}{{Simrat}} | {{CMG}}:{{AE}};{{SSW}}{{Simrat}} | ||
==Overview== | ==Overview== | ||
Common causes of oral cancers include [[premalignant]] lesion, tobacco, alcohol, [[human papillomavirus]], and [[hematopoietic]] [[stem cell]] transplantation. | Common causes of oral cancers include [[premalignant]] lesion, tobacco, alcohol, [[human papillomavirus]], and [[hematopoietic]] [[stem cell]] transplantation. 75% cases of oral cancers occur due to tobacco. It causes irritation of mucous membrane in the mouth. HPV type 16 is the most common subtype of [[Human papillomavirus|human papilloma virus]] associated with oral cancer. | ||
==Causes== | ==Causes== | ||
Common causes of oral cancer include: | Common causes of oral cancer include: | ||
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*** [[Erythroplakia]] - red patches | *** [[Erythroplakia]] - red patches | ||
*** Erythroleukoplakia - mixed red and white patches | *** Erythroleukoplakia - mixed red and white patches | ||
*** [[lichen planus]] | *** L[[lichen planus|ichen planus]] | ||
*** Oral submucous fibrosis - very common in Indian subcontinent | *** Oral submucous fibrosis - very common in Indian subcontinent | ||
*** [[actinic cheilitis]] | *** [[actinic cheilitis]] | ||
Revision as of 22:03, 8 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]:Associate Editor(s)-in-Chief: ;Sargun Singh Walia M.B.B.S.[2]Simrat Sarai, M.D. [3]
Overview
Common causes of oral cancers include premalignant lesion, tobacco, alcohol, human papillomavirus, and hematopoietic stem cell transplantation. 75% cases of oral cancers occur due to tobacco. It causes irritation of mucous membrane in the mouth. HPV type 16 is the most common subtype of human papilloma virus associated with oral cancer.
Causes
Common causes of oral cancer include:
- Premalignant lesion[1]
- Benign and morphologically altered tissue
- Premalignant lesions are of various types:
- Leukoplakia - benign white patches
- Erythroplakia - red patches
- Erythroleukoplakia - mixed red and white patches
- Lichen planus
- Oral submucous fibrosis - very common in Indian subcontinent
- actinic cheilitis
- Tobacco
- 75% cases of oral cancers occur due to tobacco.
- It causes irritation of mucous membrane in the mouth.
- Both smoking and chewing tobacco can lead to irritation of mucous membrane of the mouth.
- 60 types of carcinogens are known to occur in tobacco smoke.
- If any form of tobacco use is combined with heavy alcohol intake, the carcinogenic potential increases.
- Human Papilloma Virus(HPV)
- HPV type 16 is the most common subtype associated with oral cancer.
- Unprotected oral sexual behaviours with a patient suffering from HPV can transmit this virus.[3]
- Most commonly involves tonsils, base of the tongue and the oropharynx.
- Hematopoietic Stem Cell Transplantation
- Higher risk for squamous cell carcinoma
References
- ↑ Colvin RB, Pinn VW, Simpson BA, Dvorak HF (1973). "Cutaneous basophil hypersensitivity. IV. The "late reaction": sequel to Jones-Mote type hypersensitivity. Comparison with rabbit Arthus reaction. Effect of passive antibody on induction and expression of Jones-Mote hypersensitivity". J. Immunol. 110 (5): 1279–89. PMID 4266835.
- ↑ Stornetta A, Guidolin V, Balbo S (2018). "Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity". Cancers (Basel). 10 (1). doi:10.3390/cancers10010020. PMID 29342885.
- ↑ Shah A, Malik A, Garg A, Mair M, Nair S, Chaturvedi P (2017). "Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature". Postgrad Med J. 93 (1105): 704–709. doi:10.1136/postgradmedj-2016-134603. PMID 28778951.