Oligodendroglioma natural history, complications, and prognosis: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Line 58: Line 58:


====Tumor grade (II versus III)====
====Tumor grade (II versus III)====
*WHO grade III anaplastic oligodendrogliomas have worse prognosis comparative to low-grade tumors, with an average difference of approximately five years in overall survival
*WHO grade III anaplastic oligodendrogliomas have worse prognosis comparative to low-grade tumors, with an average difference of approximately five years in overall survival<ref name="pmid25701198">{{cite journal| author=Olar A, Wani KM, Alfaro-Munoz KD, Heathcock LE, van Thuijl HF, Gilbert MR et al.| title=IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 4 | pages= 585-96 | pmid=25701198 | doi=10.1007/s00401-015-1398-z | pmc=4369189 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25701198  }} </ref><ref name="pmid25848751">{{cite journal| author=Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y et al.| title=Mutational landscape and clonal architecture in grade II and III gliomas. | journal=Nat Genet | year= 2015 | volume= 47 | issue= 5 | pages= 458-68 | pmid=25848751 | doi=10.1038/ng.3273 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25848751  }} </ref>
*The 5-year survival rates for oligodendroglioma and [[anaplastic|anaplastic oligodendroglioma]] varying with ages are tabulated below:<ref name="survivalstats">Survival statistics for gliomas. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on</ref>
*The 5-year survival rates for oligodendroglioma and [[anaplastic|anaplastic oligodendroglioma]] varying with ages are tabulated below:<ref name="survivalstats">Survival statistics for gliomas. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on</ref>


Revision as of 23:18, 6 May 2019

Oligodendroglioma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Oligodendroglioma from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Staging

History & Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Oligodendroglioma natural history, complications, and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Oligodendroglioma natural history, complications, and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Oligodendroglioma natural history, complications, and prognosis

CDC on Oligodendroglioma natural history, complications, and prognosis

Oligodendroglioma natural history, complications, and prognosis in the news

Blogs on Oligodendroglioma natural history, complications, and prognosis

Directions to Hospitals Treating Oligodendroglioma

Risk calculators and risk factors for Oligodendroglioma natural history, complications, and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]

Overview

If left untreated, patients with oligodendroglioma may progress to develop seizures, focal neurological deficits, hydrocephalus, brain herniation, intracranial hemorrhage, and ultimately death.Common complications associated with oligodendroglioma include hydrocephalus, intracranial hemorrhage, coma, bone marrow metastasis, recurrence, venous thromboembolism, parkinsonism, and side effects of chemotherapy and radiotherapy.Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligodendroglioma may vary. However, the prognosis is generally regarded as good. The median survival time for oligodendroglioma is 11.6 years for grade II and 3.5 years for grade III.

Natural history

  • Oligodendrogliomas tend to be low grade and less aggressive than other types of gliomas
  • These tumors are slow growing
  • The tumors may be present for many years before they are diagnosed[1]
  • Anaplastic oligodendroglioma usually grows quickly
  • These tumors may develop in one place or in many places throughout the brain
  • If left untreated, patients with oligodendroglioma may progress to develop seizures, focal neurological deficits, hydrocephalus, brain herniation, intracranial hemorrhage, and ultimately death[2]
  • Recurrence is a very common feature of oligodendrogliomas
  • Recurrence can be either of the same grade or higher grade at the primary site[3]
  • Transformation into glioblastoma (grade 4) may occur a few years later, which may be associated with gain of chromosome 7 and loss of chromosome 10[3]

Complications

Common complications associated with oligodendroglioma include:[4][5][6][7][8][9][10]

Prognosis

  • Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligodendroglioma may vary
  • However, the prognosis is generally regarded as good overall[11][12]
  • Oligodendrogliomas are slowly growing tumors with prolonged survival

Prognostic factors

Following are the few prognostic factors associated with oligodendroglioma tumors:

Population based estimates

  • According to the population based estimates, despite of the prolonged clinical course of oligodendroglial tumors, outcome is almost always fatal
  • Overall median survival for patients with low-grade oligodendroglioma is approximately 10 to 15 years[13][14]
  • Median survival for patients with anaplastic oligodendroglioma is approximately 5 to 9 years[11]
  • Median survival of patients with 1p/19q-codeleted oligodendrogliomas who are treated with radiation plus procarbazine, lomustine, and vincristine (PCV) may be closer to 20 years for grade II tumors and 15 years for grade III tumors[15][16][17]
  • The presence of 1p19q codeletion is associated with a better prognosis abd greater chemosensitivity[4][18][19][20]
  • Several other molecular markers have a potential clinical significance as IDH1 mutations, confirming the strong prognostic role for overall survival[21][22][23][24][25][26]
  • The presence of EGFR gene mutation is associated with a worse prognosis[27]

Clinical factors

Following is a list of more commonly identified clinical features that predict worse overall survival:

  • Older age
  • Poor functional status
  • Baseline neurologic deficits
  • Nonepilepsy presentation
  • Tumor location other than frontal and parietal lobes
  • Large tumor size (>4 to 5 cm)

Clinical features that are independently associated with improved overall survival in patients with anaplastic oligodendroglial tumors include:[28][29]

  • Younger age
  • Confirmed absence of residual tumor by imaging after surgery
  • Frontal tumor location
  • Good performance status

Tumor grade (II versus III)

  • WHO grade III anaplastic oligodendrogliomas have worse prognosis comparative to low-grade tumors, with an average difference of approximately five years in overall survival[26][30]
  • The 5-year survival rates for oligodendroglioma and anaplastic oligodendroglioma varying with ages are tabulated below:[31]
WHO grade of tumor Age 5-year survival rate
Oligodendroglioma (Grade II) 20-44 82%
45-54 67%
55-64 48%
Anaplastic oligodendroglioma (Grade III) 20-44 64%
45-54 50%
55-64 23%

References

  1. ↑ Survival by prognostic factors. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on
  2. ↑ Manousaki M, Papadaki H, Papavdi A, Kranioti EF, Mylonakis P, Varakis J; et al. (2011). "Sudden unexpected death from oligodendroglioma: a case report and review of the literature". Am J Forensic Med Pathol. 32 (4): 336–40. doi:10.1097/PAF.0b013e3181d3dc86. PMID 20375839.
  3. ↑ 3.0 3.1 Kocaeli H, Yakut T, Bekar A, Taşkapilioğlu O, Tolunay S (2006). "Glioblastomatous recurrence of oligodendroglioma remote from the original site: a case report". Surg Neurol. 66 (6): 627–30, discussion 630-1. doi:10.1016/j.surneu.2006.02.049. PMID 17145331.
  4. ↑ 4.0 4.1 Simonetti G, Gaviani P, Botturi A, Innocenti A, Lamperti E, Silvani A (2015). "Clinical management of grade III oligodendroglioma". Cancer Manag Res. 7: 213–23. doi:10.2147/CMAR.S56975. PMC 4524382. PMID 26251628.
  5. ↑ Guppy KH, Akins PT, Moes GS, Prados MD (2009). "Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis". J Neurosurg Spine. 10 (6): 557–63. doi:10.3171/2009.2.SPINE08853. PMID 19558288.
  6. ↑ Sharma A, Agarwal A, Sharma MC, Anand M, Agarwal S, Raina V (2003). "Bone marrow metastasis in anaplastic oligodendroglioma". Int J Clin Pract. 57 (4): 351–2. PMID 12800473.
  7. ↑ Solitare GB, Robinson F, Lamarche JB (1967). "Oligodendroglioma: recurrence following an exceptionally long postoperative symptom-free interval". Can Med Assoc J. 97 (14): 862–5. PMC 1923454. PMID 6051252.
  8. ↑ Harada K, Kiya K, Matsumura S, Mori S, Uozumi T (1982). "Spontaneous intracranial hemorrhage caused by oligodendroglioma--a case report and review of the literature". Neurol Med Chir (Tokyo). 22 (1): 81–4. PMID 6176898.
  9. ↑ Hentschel S, Toyota B (2003). "Intracranial malignant glioma presenting as subarachnoid hemorrhage". Can J Neurol Sci. 30 (1): 63–6. PMID 12619787.
  10. ↑ Krauss JK, Paduch T, Mundinger F, Seeger W (1995). "Parkinsonism and rest tremor secondary to supratentorial tumours sparing the basal ganglia". Acta Neurochir (Wien). 133 (1–2): 22–9. PMID 8561031.
  11. ↑ 11.0 11.1 Ohgaki H, Kleihues P (2005). "Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas". J Neuropathol Exp Neurol. 64 (6): 479–89. PMID 15977639.
  12. ↑ Hartmann C, Hentschel B, Wick W, Capper D, Felsberg J, Simon M; et al. (2010). "Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas". Acta Neuropathol. 120 (6): 707–18. doi:10.1007/s00401-010-0781-z. PMID 21088844.
  13. ↑ Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C; et al. (2017). "CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014". Neuro Oncol. 19 (suppl_5): v1–v88. doi:10.1093/neuonc/nox158. PMC 5693142. PMID 29117289.
  14. ↑ Lassman AB, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF; et al. (2011). "International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors". Neuro Oncol. 13 (6): 649–59. doi:10.1093/neuonc/nor040. PMC 3107101. PMID 21636710.
  15. ↑ Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR; et al. (2016). "Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma". N Engl J Med. 374 (14): 1344–55. doi:10.1056/NEJMoa1500925. PMC 5170873. PMID 27050206.
  16. ↑ van den Bent MJ, Brandes AA, Taphoorn MJ, Kros JM, Kouwenhoven MC, Delattre JY; et al. (2013). "Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951". J Clin Oncol. 31 (3): 344–50. doi:10.1200/JCO.2012.43.2229. PMID 23071237.
  17. ↑ Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J; et al. (2013). "Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402". J Clin Oncol. 31 (3): 337–43. doi:10.1200/JCO.2012.43.2674. PMC 3732012. PMID 23071247.
  18. ↑ Molecular Pathology of Oligodendroglioma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Oligodendroglioma
  19. ↑ Boots-Sprenger SH, Sijben A, Rijntjes J, Tops BB, Idema AJ, Rivera AL; et al. (2013). "Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution". Mod Pathol. 26 (7): 922–9. doi:10.1038/modpathol.2012.166. PMID 23429602.
  20. ↑ McDonald JM, See SJ, Tremont IW, Colman H, Gilbert MR, Groves M; et al. (2005). "The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors". Cancer. 104 (7): 1468–77. doi:10.1002/cncr.21338. PMID 16088966.
  21. ↑ Takahashi Y, Nakamura H, Makino K, Hide T, Muta D, Kamada H; et al. (2013). "Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients". World J Surg Oncol. 11: 284. doi:10.1186/1477-7819-11-284. PMC 3874767. PMID 24160898.
  22. ↑ Wick W, Meisner C, Hentschel B, Platten M, Schilling A, Wiestler B; et al. (2013). "Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation". Neurology. 81 (17): 1515–22. doi:10.1212/WNL.0b013e3182a95680. PMID 24068788.
  23. ↑ Perrech M, Dreher L, Röhn G, Stavrinou P, Krischek B, Toliat M; et al. (2019). "Qualitative and Quantitative Analysis of IDH1 Mutation in Progressive Gliomas by Allele-Specific qPCR and Western Blot Analysis". Technol Cancer Res Treat. 18: 1533033819828396. doi:10.1177/1533033819828396. PMC 6457076. PMID 30943868.
  24. ↑ Lewandowska MA, Furtak J, Szylberg T, Roszkowski K, Windorbska W, Rytlewska J; et al. (2014). "An analysis of the prognostic value of IDH1 (isocitrate dehydrogenase 1) mutation in Polish glioma patients". Mol Diagn Ther. 18 (1): 45–53. doi:10.1007/s40291-013-0050-7. PMC 3899509. PMID 23934769.
  25. ↑ Yao Y, Chan AK, Qin ZY, Chen LC, Zhang X, Pang JC; et al. (2013). "Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival". PLoS One. 8 (6): e67421. doi:10.1371/journal.pone.0067421. PMC 3696098. PMID 23840696.
  26. ↑ 26.0 26.1 Olar A, Wani KM, Alfaro-Munoz KD, Heathcock LE, van Thuijl HF, Gilbert MR; et al. (2015). "IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas". Acta Neuropathol. 129 (4): 585–96. doi:10.1007/s00401-015-1398-z. PMC 4369189. PMID 25701198.
  27. ↑ Wesseling P, van den Bent M, Perry A (2015). "Oligodendroglioma: pathology, molecular mechanisms and markers". Acta Neuropathol. 129 (6): 809–27. doi:10.1007/s00401-015-1424-1. PMC 4436696. PMID 25943885.
  28. ↑ Gorlia T, Delattre JY, Brandes AA, Kros JM, Taphoorn MJ, Kouwenhoven MC; et al. (2013). "New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brain Tumour Group Study 26951". Eur J Cancer. 49 (16): 3477–85. doi:10.1016/j.ejca.2013.06.039. PMID 23896377.
  29. ↑ Panageas KS, Reiner AS, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL; et al. (2014). "Recursive partitioning analysis of prognostic variables in newly diagnosed anaplastic oligodendroglial tumors". Neuro Oncol. 16 (11): 1541–6. doi:10.1093/neuonc/nou083. PMC 4201067. PMID 24997140.
  30. ↑ Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y; et al. (2015). "Mutational landscape and clonal architecture in grade II and III gliomas". Nat Genet. 47 (5): 458–68. doi:10.1038/ng.3273. PMID 25848751.
  31. ↑ Survival statistics for gliomas. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Oligodendroglioma_natural_history,_complications,_and_prognosis&oldid=1567002"