Non-Polio enterovirus infections pathophysiology: Difference between revisions

	Non-Polio enterovirus infections Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Non-Polio enterovirus infections from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
Other Diagnostic Studies
Treatment
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Non-Polio enterovirus infections pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Non-Polio enterovirus infections pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Non-Polio enterovirus infections pathophysiology
CDC on Non-Polio enterovirus infections pathophysiology
Non-Polio enterovirus infections pathophysiology in the news
Blogs on Non-Polio enterovirus infections pathophysiology
Directions to Hospitals Treating Non-Polio enterovirus infections
Risk calculators and risk factors for Non-Polio enterovirus infections pathophysiology

VisualWikitext

Revision as of 18:23, 4 February 2023

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: {Sujaya}}

Overview

The cellular uptake of enteorviruses is mediated by receptor molecules such as, intracellular adhesion molecule-1 (ICAM-1), low-density lipoprotein receptor (LDL-R), and non-protein factors such as heparan sulfate and sialic acid. Incubation periods range from 12 hours to 5 days, with experimental volunteers reporting symptoms several hours after aritficial inoculation.

Pathophysiology

Non-polio non-rhinovirus enteroviruses

Rhinoviruses

References

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Non-Polio enterovirus infections}}
-{{CMG}}
+{{CMG}} {{AE}} {Sujaya}}
-Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
 ==Overview==
-Enteroviruses can be found in [[respiratory]] secretions (e.g., [[saliva]], [[sputum]], or [[nasal mucus]]) and [[stool]] of an infected person. Other persons may become infected by direct contact with secretions or [[stool]] from an infected person or by contact with contaminated surfaces or objects, such as a drinking glass or telephone. Parents, teachers, and child care center workers may also become infected by contamination of the hands with stool from an infected infant or toddler during diaper changes.
+The [[cellular]] uptake of [[enteorviruses]] is mediated by [[receptor]] [[molecules]] such as, [[intracellular]] [[adhesion]] [[molecule]]-1 ([[ICAM-1)]], low-density [[lipoprotein]] [[receptor]] ([[LDL-R]]), and [[non-protein]] factors such as [[heparan sulfate]] and [[sialic acid]]. [[Incubation]] [[periods]] range from 12 hours to 5 days, with [[experimental]] volunteers reporting [[symptoms]] several hours after aritficial [[inoculation]].
 ==Pathophysiology==
-Less commonly, some persons have "aseptic" or [[viral meningitis]]. Rarely, a person may develop an illness that affects the heart ([[myocarditis]]) or the brain ([[encephalitis]]) or causes [[paralysis]]. Enterovirus infections are suspected to play a role in the development of juvenile-onset [[diabetes mellitus]] (sugar diabetes). Newborns infected with an enterovirus may rarely develop severe illness and die from infection. Usually, there are no long-term complications from the mild illnesses or from "aseptic" meningitis. Some patients who have paralysis or encephalitis, however, do not fully recover. Persons who develop heart failure (dilated [[cardiomyopathy]]) from [[myocarditis]] may require long-term care for their conditions.
+===[[Non-polio]] [[non-rhinovirus]] [[enteroviruses]]===
+===[[Rhinoviruses]]===
-===Genetics===
-Enteroviruses are members of the [[picornavirus]] family, a large and diverse group of small [[RNA viruses]] characterized by a single positive-strand genomic RNA. All enteroviruses contain a [[genome]] of approximately 7,500 bases and are known to have a high [[mutation rate]] due to [[Virus#Replication_cycle|low-fidelity replication]] and frequent [[genetic recombination|recombination]].<ref name=China>{{cite journal |author=Li L, He Y, Yang H, ''et al.'' |title=Genetic Characteristics of Human Enterovirus 71 and Coxsackievirus A16 Circulating from 1999 to 2004 in Shenzhen, People's Republic of China |journal=J. Clin. Microbiol. |volume=43 |issue=8 |pages=3835–9 |year=2005 |pmid=16081920 |pmc=1233905 |doi=10.1128/JCM.43.8.3835-3839.2005 |url=http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=16081920}}</ref> After infection of the host cell, the genome is translated in a cap-independent manner into a single [[polyprotein]], which is subsequently processed by virus-encoded [[protease]]s into the structural [[capsid]] proteins and the nonstructural proteins, which are mainly involved in the replication of the virus.<ref>{{cite journal |author=Merkle I, van Ooij MJ, van Kuppeveld FJ, ''et al.'' |title=Biological Significance of a Human Enterovirus B-Specific RNA Element in the 3′ Nontranslated Region |journal=J. Virol. |volume=76 |issue=19 |pages=9900–9 |year=2002 |pmid=12208967 |pmc=136489 |doi= 10.1128/JVI.76.19.9900-9909.2002|url=http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=12208967}}</ref>
 == References ==
 {{Reflist|2}}