Non-Hodgkin lymphoma diagnostic study of choice

Revision as of 04:52, 29 December 2018 by Shyam Patel (talk | contribs)
Jump to navigation Jump to search

Non-Hodgkin lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Non-Hodgkin's Lymphoma

Differentiating Non-Hodgkin Lymphoma from Other Diseases
Differentiating Types of Non-Hodgkin's Lymphoma

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Biopsy

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Non-Hodgkin lymphoma diagnostic study of choice On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Non-Hodgkin lymphoma diagnostic study of choice

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Non-Hodgkin lymphoma diagnostic study of choice

CDC on Non-Hodgkin lymphoma diagnostic study of choice

Non-Hodgkin lymphoma diagnostic study of choice in the news

Blogs on Non-Hodgkin lymphoma diagnostic study of choice

Directions to Hospitals Treating Non-Hodgkin lymphoma

Risk calculators and risk factors for Non-Hodgkin lymphoma diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [3]

Overview

The diagnostic study of choice for non-Hodgkin lymphoma is excisional lymph node biopsy. A bone marrow biopsy is an alternative to a lymph node biopsy.

Diagnostic study of choice

  • The diagnostic study of choice for non-Hodgkin's lymphoma is excisional lymph node biopsy. An excisional biopsy is needed because it preserves the architecture of the lymph node and allows for precise determination of the type of lymphoma. Fine needle aspiration biopsy is insufficient. In addition to light microscopy evaluation of the excisional biopsy samples, the immunophenotypic analysis with immunohistochemistry helps to determine non-Hodgkin's lymphoma subtypes and distinguish non-Hodgkin's lymphoma from T cell rich large B cell lymphoma and anaplastic large cell lymphoma. The presence of CD20 positive clonal B cells defines non-Hodgkin lymphoma. Flow cytometry is an effective method in differentiating between Hodgkin's lymphoma and non-Hodgkin lymphoma, as well as subtypes of non-Hodgkin lymphoma.
  • A bone marrow biopsy can also be done to diagnose non-Hodgkin lymphoma if there is sufficient evidence of marrow involvement (i.e. presence of cytopenias). Non-Hodgkin lymphoma cells originate in the bone marrow, which is the site of B cell production and maturation. A length of 2cm of the core biopsy is generally needed for diagnosis, which is in contrast to diagnostic requirements for leukemias. A bone marrow is not the diagnostic study of choice for Hodgkin lymphoma if a lymph node can be biopsied.


References

Template:Hematology


Template:WikiDoc Sources