Neurofibroma medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Neurofibroma}} | {{Neurofibroma}} | ||
{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}}{{S.M.}} {{SC}} | ||
==Overview== | ==Overview== | ||
The predominant [[therapy]] for [[neurofibroma]] is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[medications]] such as [[ACE inhibitor|ACE inhibitors]] may be required. | |||
== | ==Medical Therapy== | ||
[[ | '''Chemotherapy''' | ||
* Once a [[plexiform neurofibroma]] has undergone [[malignant transformation]], [[chemotherapy]] can be used as treatment<ref name="radio">Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015 </ref> | |||
'''Radiation''' | |||
* [[Radiation]] is generally not used as a treatment for [[plexiform neurofibroma]]s because of concerns that this could actually [[Promoter|promote]] [[malignant]] [[Transformation (genetics)|transformation]] | |||
* There has even been a documented case of a [[schwannoma]] being induced from a [[neurofibroma]] due to [[radiation therapy]]<ref name="pmid8998885">{{cite journal |author=Isler MH, Fogaça MF, Mankin HJ. |title=Radiation induced malignant schwannoma arising in a neurofibroma |journal=Clinical Orthopaedics and Related Research |issue=325 |pages=251–5 |year=1996 |pmid=8998885|doi=10.1097/00003086-199604000-00031 |volume=325}}</ref> | |||
'''Medications''' | |||
* [[ACE inhibitor]]s have been proposed as a novel treatment of [[Neurofibroma|neurofibromas]]<ref name="pmid18157575">{{cite journal |author=Namazi H. |title=ACE inhibitors: a novel treatment for neurofibroma |journal=Clinical Orthopaedics and Related Research |volume=15 |issue=5 |pages=1538–9 |year=2008 |pmid=18157575|doi=10.1245/s10434-007-9737-5}}</ref> | |||
* [[ACE inhibitor]]s are currently used to: | |||
**Treat [[hypertension]] and [[congestive heart failure]] | |||
**Avert remodeling and [[reinfarction]] after [[myocardial infarction]] | |||
**Ameliorate [[diabetic nephropathy]] and other [[Renal disease|renal diseases]] | |||
* [[ACE inhibitor]]s work by indirectly down regulating [[TGF beta|TGF-beta]], which is a [[growth factor]] that has been shown to influence the [[development]] of [[tumors]]<ref name="pmid18157575">{{cite journal |author=Namazi H. |title=ACE inhibitors: a novel treatment for neurofibroma |journal=Clinical Orthopaedics and Related Research |volume=15 |issue=5 |pages=1538–9 |year=2008 |pmid=18157575|doi=10.1245/s10434-007-9737-5}}</ref> | |||
==References== | ==References== | ||
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[[Category:Neurosurgery]] | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
The predominant therapy for neurofibroma is surgical resection. Adjunctive chemotherapy and medications such as ACE inhibitors may be required.
Medical Therapy
Chemotherapy
- Once a plexiform neurofibroma has undergone malignant transformation, chemotherapy can be used as treatment[1]
Radiation
- Radiation is generally not used as a treatment for plexiform neurofibromas because of concerns that this could actually promote malignant transformation
- There has even been a documented case of a schwannoma being induced from a neurofibroma due to radiation therapy[2]
Medications
- ACE inhibitors have been proposed as a novel treatment of neurofibromas[3]
- ACE inhibitors are currently used to:
- Treat hypertension and congestive heart failure
- Avert remodeling and reinfarction after myocardial infarction
- Ameliorate diabetic nephropathy and other renal diseases
- ACE inhibitors work by indirectly down regulating TGF-beta, which is a growth factor that has been shown to influence the development of tumors[3]
References
- ↑ Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015
- ↑ Isler MH, Fogaça MF, Mankin HJ. (1996). "Radiation induced malignant schwannoma arising in a neurofibroma". Clinical Orthopaedics and Related Research. 325 (325): 251–5. doi:10.1097/00003086-199604000-00031. PMID 8998885.
- ↑ 3.0 3.1 Namazi H. (2008). "ACE inhibitors: a novel treatment for neurofibroma". Clinical Orthopaedics and Related Research. 15 (5): 1538–9. doi:10.1245/s10434-007-9737-5. PMID 18157575.