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{{SI}}
{{Neurofibroma}}


'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{CMG}}; {{AE}} {{KS}} {{SC}}
{{CMG}}; {{AE}} {{S.M.}}, {{KS}}, {{SC}}


==Overview==
{{SK}} Endoneural fibroma, Myxofibroma of nerve sheath, Neurofibromyxoma, Perineural fibroblastoma, Perineural fibroma


'''Neurofibroma''' is a type of [[nerve sheath tumor]]. In contrast to [[schwannoma]]s - another type of [[tumor]] arising from the [[Schwann cell]]s - neurofibromas incorporate all sorts of cells and structural elements in addition to the Schwann cells.<ref> Miller RT. Immunohistochemistry in the differential diagnosis of schwannoma and neurofibroma.  Propath 2004 Oct. http://www.ihcworld.com/_newsletter/2004/2004-10_NF_vs_schwannoma_v1.pdf</ref>
==[[Neurofibroma overview|Overview]]==


==Pathophysiology==
==[[Neurofibroma historical perspective|Historical Perspective]]==
Neurofibromas infiltrate the nerve and splay apart the individual nerve fibers. Although usually [[benign]], Neurofibromas can sometimes degenerate into [[cancer]].


Single neurofibromas often occur in middle and old age and grow at the margins of the peripheral nerves, displacing the nerve's main body.
==[[Neurofibroma classification|Classification]]==
 
==[[Neurofibroma pathophysiology|Pathophysiology]]==
 
==[[Neurofibroma causes|Causes]]==
 
==[[Neurofibroma differential diagnosis|Differentiating Neurofibroma from other Diseases]]==
 
==[[Neurofibroma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Neurofibroma risk factors|Risk Factors]]==
 
==[[Neurofibroma screening|Screening]]==
 
==[[Neurofibroma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


The [[vestibulocochlear nerve|vestibulocochlear (acoustic) nerve]] is the most commonly affected, (see [[acoustic neuroma]]).
Other [[cranial nerves]] and [[spinal nerves]] are less commonly involved.
==Diagnosis==
==Diagnosis==
===Physical Examination===
[[Neurofibroma diagnostic criteria|Diagnostic criteria]] | [[Neurofibroma history and symptoms|History and Symptoms]] | [[Neurofibroma physical examination|Physical Examination]] | [[Neurofibroma laboratory findings|Laboratory Findings]]  | [[Neurofibroma x ray|X Ray]] | [[Neurofibroma CT|CT]] | [[Neurofibroma MRI|MRI]] | [[Neurofibroma ultrasound|Ultrasound]] | [[Neurofibroma other imaging findings|Other Imaging Findings]] | [[Neurofibroma other diagnostic studies|Other Diagnostic Studies]] | [[Neurofibroma biopsy|Biopsy]]
====Skin====
=====Trunk=====
<gallery>
Image:Neurofibroma01.jpg|Neurofibroma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>


Image:Neurofibroma02.jpg|Neurofibroma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
==Treatment==
</gallery>
[[Neurofibroma medical therapy|Medical therapy]] | [[Neurofibroma surgery|Surgery]] | [[Neurofibroma primary prevention|Primary prevention]] | [[Neurofibroma secondary prevention|Secondary prevention]] | [[Neurofibroma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Neurofibroma future or investigational therapies|Future or Investigational Therapies]]


==Treatment==
==Case Studies==
[[Surgical]] resection is curative, although tumors are not easily removable if they surround important nerves such as the optic nerve. There is a risk of functional damage due to interference with the [[nerve]].  [[Debulking]] may be helpful.<ref name="pmid12828709">{{cite journal |author=Babovic S, Bite U, Karnes PS, Babovic-Vuksanovic D |title=Liposuction: a less invasive surgical method of debulking plexiform neurofibromas |journal=Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] |volume=29 |issue=7 |pages=785–7 |year=2003 |pmid=12828709 |doi=}}</ref>
[[Neurofibroma case study one|Case #1]]


==References==
==Related Chapters==
{{Reflist|2}}
* [[Neurofibromatosis type I]]


[[Category:Disease]]
[[Category:Disease]]
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[[category:Dermatology]]
[[category:Dermatology]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Overview complete]]


{{Nervous tissue tumors}}
{{Nervous tissue tumors}}
[[de:Schwannom]]
[[pl:Nerwiakowłókniak]]


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Latest revision as of 20:47, 19 August 2020

Neurofibroma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neurofibroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Neurofibroma On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Neurofibroma

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Neurofibroma

CDC on Neurofibroma

Neurofibroma in the news

Blogs on Neurofibroma

Directions to Hospitals Treating Neurofibroma

Risk calculators and risk factors for Neurofibroma

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2], Kiran Singh, M.D. [3], Shanshan Cen, M.D. [4]

Synonyms and keywords: Endoneural fibroma, Myxofibroma of nerve sheath, Neurofibromyxoma, Perineural fibroblastoma, Perineural fibroma

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neurofibroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic criteria | History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies | Biopsy

Treatment

Medical therapy | Surgery | Primary prevention | Secondary prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

Template:Nervous tissue tumors


Template:WikiDoc Sources

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