Nephrotic syndrome classification: Difference between revisions

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__NOTOC__
__NOTOC__
{{Nephrotic syndrome}}
{{Nephrotic syndrome}}
{{CMG}} {{APM}}; {{AE}} {{OO}} [[User:YazanDaaboul|Yazan Daaboul]],  
{{CMG}}, {{APM}}; {{AE}} {{OO}}, [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]]
 
[[User:Sergekorjian|Serge Korjian]]


==Overview==
==Overview==
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.  Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary [[glomerular]] disease. Secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as [[infection]]s, [[malignancies]], systemic conditions, and [[medication]]s.
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.  Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary [[glomerular]] disease. The secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as [[infection]]s, [[malignancies]], systemic conditions, and [[medication]]s.


==Classification==
==Classification==
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* Below table lists different types of nephrotic syndromes:<ref name="pmid10793022">{{cite journal |vauthors=Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ |title=Changing incidence of glomerular diseases in adults |journal=Am. J. Kidney Dis. |volume=35 |issue=5 |pages=878–83 |date=May 2000 |pmid=10793022 |doi= |url=}}</ref><ref name="pmid15327377">{{cite journal |vauthors=Heaf J |title=The Danish Renal Biopsy Register |journal=Kidney Int. |volume=66 |issue=3 |pages=895–7 |date=September 2004 |pmid=15327377 |doi=10.1111/j.1523-1755.2004.00832.x |url=}}</ref><ref name="pmid10793022">{{cite journal |vauthors=Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ |title=Changing incidence of glomerular diseases in adults |journal=Am. J. Kidney Dis. |volume=35 |issue=5 |pages=878–83 |date=May 2000 |pmid=10793022 |doi= |url=}}</ref>
* Below table lists different types of nephrotic syndromes:<ref name="pmid10793022">{{cite journal |vauthors=Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ |title=Changing incidence of glomerular diseases in adults |journal=Am. J. Kidney Dis. |volume=35 |issue=5 |pages=878–83 |date=May 2000 |pmid=10793022 |doi= |url=}}</ref><ref name="pmid15327377">{{cite journal |vauthors=Heaf J |title=The Danish Renal Biopsy Register |journal=Kidney Int. |volume=66 |issue=3 |pages=895–7 |date=September 2004 |pmid=15327377 |doi=10.1111/j.1523-1755.2004.00832.x |url=}}</ref><ref name="pmid28392820">{{cite journal |vauthors=Ha TS |title=Genetics of hereditary nephrotic syndrome: a clinical review |journal=Korean J Pediatr |volume=60 |issue=3 |pages=55–63 |date=March 2017 |pmid=28392820 |pmc=5383633 |doi=10.3345/kjp.2017.60.3.55 |url=}}</ref>
{| class="wikitable"
{|  
!Different types of nephrotic syndromes
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Different types of nephrotic syndromes
! colspan="2" |Disease name
! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease name
|-
|-
| rowspan="6" |Podocytopathies
! rowspan="6" align="center" style="background:#DCDCDC;" + |Podocytopathies
| rowspan="2" |Primary  
| rowspan="2" align="left" style="background:#F5F5F5;" + |Primary  
|[[Minimal change disease]]
| align="left" style="background:#F5F5F5;" + |[[Minimal change disease]]
|-
|-
|[[Focal segmental glomerulosclerosis]] ([[Focal segmental glomerulosclerosis|FSGS]])
| align="left" style="background:#F5F5F5;" + |[[Focal segmental glomerulosclerosis]] ([[Focal segmental glomerulosclerosis|FSGS]])
|-
|-
| rowspan="4" |Secondary
| rowspan="4" align="left" style="background:#F5F5F5;" + |Secondary
|Infection such as:  
| align="left" style="background:#F5F5F5;" + |Infection such as:  
* [[Human Immunodeficiency Virus (HIV)|HIV]]
* [[Human Immunodeficiency Virus (HIV)|HIV]]
|-
|-
|Drugs/toxins such as:
| align="left" style="background:#F5F5F5;" + |Drugs/toxins such as:
* [[Non-steroidal anti-inflammatory drug|NSAIDs]]
* [[Non-steroidal anti-inflammatory drug|NSAIDs]]
* Interferon
* Interferon
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* Envenomation
* Envenomation
|-
|-
|Malignancies such as:
| align="left" style="background:#F5F5F5;" + |Malignancies such as:
* [[Hodgkin's lymphoma|Hodgkin lymphoma]]
* [[Hodgkin's lymphoma|Hodgkin lymphoma]]
* [[Thymoma]]
* [[Thymoma]]
|-
|-
|Genetic disorders such as:  
| align="left" style="background:#F5F5F5;" + |Genetic disorders such as:  
* [[Nephrin]] mutations
* [[Nephrin]] mutations
* [[Podocin]] gene mutations
* [[Podocin]] gene mutations
|-
|-
| rowspan="2" |[[Membranous glomerulonephritis]]
! rowspan="2" align="center" style="background:#DCDCDC;" + |[[Membranous glomerulonephritis]]
|Primary  
| align="left" style="background:#F5F5F5;" + |Primary  
|[[Membranous nephritis|Membranous nephropathy]]
| align="left" style="background:#F5F5F5;" + |[[Membranous nephritis|Membranous nephropathy]]
|-
|-
|Secondary
| align="left" style="background:#F5F5F5;" + |Secondary
|
| align="left" style="background:#F5F5F5;" + |
* [[Drugs]]
* [[Drugs]]
* [[Toxin|Toxins]]
* [[Toxin|Toxins]]
* [[Cancer|Malignancies]]
* [[Cancer|Malignancies]]
|-
|-
|[[Membranoproliferative glomerulonephritis]]
! align="center" style="background:#DCDCDC;" + |[[Membranoproliferative glomerulonephritis]]
|Secondary
| align="left" style="background:#F5F5F5;" + |Secondary
|
| align="left" style="background:#F5F5F5;" + |
* Autoimmune disorders such as:
* Autoimmune disorders such as:
** [[SLE]]
** [[SLE]]
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* [[Thrombotic microangiopathy]]
* [[Thrombotic microangiopathy]]
|-
|-
|Hereditary Nephropathy<ref name="pmid28392820">{{cite journal |vauthors=Ha TS |title=Genetics of hereditary nephrotic syndrome: a clinical review |journal=Korean J Pediatr |volume=60 |issue=3 |pages=55–63 |date=March 2017 |pmid=28392820 |pmc=5383633 |doi=10.3345/kjp.2017.60.3.55 |url=}}</ref>
! align="center" style="background:#DCDCDC;" + |Hereditary Nephropathy
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Alport syndrome]]
* [[Alport syndrome]]
* [[IgA nephropathy]]
* [[IgA nephropathy]]
* C1q nephropathy
* C1q nephropathy
|-
|-
|Glomerular deposition diseases
! align="center" style="background:#DCDCDC;" + |[[Glomerular deposition disease|Glomerular deposition diseases]]
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Diabetes mellitus]]
* [[Diabetes mellitus]]
* [[Amyloidosis]]
* [[Amyloidosis]]
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* Nodular glomeruloneohritis associated with heavy [[smoking]]
* Nodular glomeruloneohritis associated with heavy [[smoking]]
|-
|-
|Other lesions
! align="center" style="background:#DCDCDC;" + |Others
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Fabry's disease|Fabry disease]]
* [[Fabry's disease|Fabry disease]]
* [[Nail-patella syndrome]]
* [[Nail-patella syndrome]]
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Kidney diseases]]
 
[[Category:Medicine]]
[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Pediatrics]]
[[Category:Urology]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Syndromes]]
[[Category:Emergency medicine]]
[[Category:Needs overview]]
[[Category:Primary care]]
{{WH}}
{{WS}}

Latest revision as of 22:57, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3], Yazan Daaboul, Serge Korjian

Overview

Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology. Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary glomerular disease. The secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as infections, malignancies, systemic conditions, and medications.

Classification

  • Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.[1]
 
 
 
Nephrotic
syndrome
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary
 
 
 
Secondary
  • Below table lists different types of nephrotic syndromes:[2][3][4]
Different types of nephrotic syndromes Disease name
Podocytopathies Primary Minimal change disease
Focal segmental glomerulosclerosis (FSGS)
Secondary Infection such as:
Drugs/toxins such as:
  • NSAIDs
  • Interferon
  • Pamidronate
  • Lithium
  • Vaccins
  • Envenomation
Malignancies such as:
Genetic disorders such as:
Membranous glomerulonephritis Primary Membranous nephropathy
Secondary
Membranoproliferative glomerulonephritis Secondary
Hereditary Nephropathy
Glomerular deposition diseases
Others

References

  1. Kodner C (2009). "Nephrotic syndrome in adults: diagnosis and management". Am Fam Physician. 80 (10): 1129–34. PMID 19904897.
  2. Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ (May 2000). "Changing incidence of glomerular diseases in adults". Am. J. Kidney Dis. 35 (5): 878–83. PMID 10793022.
  3. Heaf J (September 2004). "The Danish Renal Biopsy Register". Kidney Int. 66 (3): 895–7. doi:10.1111/j.1523-1755.2004.00832.x. PMID 15327377.
  4. Ha TS (March 2017). "Genetics of hereditary nephrotic syndrome: a clinical review". Korean J Pediatr. 60 (3): 55–63. doi:10.3345/kjp.2017.60.3.55. PMC 5383633. PMID 28392820.