Nephrotic syndrome classification: Difference between revisions

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__NOTOC__
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{{Nephrotic syndrome}}
{{Nephrotic syndrome}}
{{CMG}} {{APM}}; {{AE}} {{OO}} [[User:YazanDaaboul|Yazan Daaboul]],  
{{CMG}}, {{APM}}; {{AE}} {{OO}}, [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]]
 
[[User:Sergekorjian|Serge Korjian]]


==Overview==
==Overview==
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.  Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary [[glomerular]] disease. Secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as [[infection]]s, [[malignancies]], systemic conditions, and [[medication]]s.
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.  Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary [[glomerular]] disease. The secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as [[infection]]s, [[malignancies]], systemic conditions, and [[medication]]s.


==Classification==
==Classification==
===Etiologic Classification===
* Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.<ref name="pmid19904897">{{cite journal| author=Kodner C| title=Nephrotic syndrome in adults: diagnosis and management. | journal=Am Fam Physician | year= 2009 | volume= 80 | issue= 10 | pages= 1129-34 | pmid=19904897 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904897 }} </ref>
Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.<ref name="pmid19904897">{{cite journal| author=Kodner C| title=Nephrotic syndrome in adults: diagnosis and management. | journal=Am Fam Physician | year= 2009 | volume= 80 | issue= 10 | pages= 1129-34 | pmid=19904897 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904897 }} </ref>
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Below table lists different typesof nephrotic syndromes:
* Below table lists different types of nephrotic syndromes:<ref name="pmid10793022">{{cite journal |vauthors=Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ |title=Changing incidence of glomerular diseases in adults |journal=Am. J. Kidney Dis. |volume=35 |issue=5 |pages=878–83 |date=May 2000 |pmid=10793022 |doi= |url=}}</ref><ref name="pmid15327377">{{cite journal |vauthors=Heaf J |title=The Danish Renal Biopsy Register |journal=Kidney Int. |volume=66 |issue=3 |pages=895–7 |date=September 2004 |pmid=15327377 |doi=10.1111/j.1523-1755.2004.00832.x |url=}}</ref><ref name="pmid28392820">{{cite journal |vauthors=Ha TS |title=Genetics of hereditary nephrotic syndrome: a clinical review |journal=Korean J Pediatr |volume=60 |issue=3 |pages=55–63 |date=March 2017 |pmid=28392820 |pmc=5383633 |doi=10.3345/kjp.2017.60.3.55 |url=}}</ref>
{| class="wikitable"
{|
!Different types of nephrotic syndromes
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Different types of nephrotic syndromes
! colspan="2" |Disease name
! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease name
|-
|-
| rowspan="6" |Podocytopathies
! rowspan="6" align="center" style="background:#DCDCDC;" + |Podocytopathies
| rowspan="2" |Primary  
| rowspan="2" align="left" style="background:#F5F5F5;" + |Primary  
|Primary [[minimal change disease]]
| align="left" style="background:#F5F5F5;" + |[[Minimal change disease]]
|-
|-
|Primary [[Focal segmental glomerulosclerosis|FSGS]]
| align="left" style="background:#F5F5F5;" + |[[Focal segmental glomerulosclerosis]] ([[Focal segmental glomerulosclerosis|FSGS]])
|-
|-
| rowspan="4" |Secondary
| rowspan="4" align="left" style="background:#F5F5F5;" + |Secondary
|Infection: [[Human Immunodeficiency Virus (HIV)|HIV]]
| align="left" style="background:#F5F5F5;" + |Infection such as:  
* [[Human Immunodeficiency Virus (HIV)|HIV]]
|-
|-
|Drugs/toxins: [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[interferon]], [[pamidronate]], [[lithium]], [[Vaccination|vaccins]], [[envenomation]]
| align="left" style="background:#F5F5F5;" + |Drugs/toxins such as:
* [[Non-steroidal anti-inflammatory drug|NSAIDs]]
* Interferon
* Pamidronate
* Lithium
* Vaccins
* Envenomation
|-
|-
|Malignancies: [[Hodgkin's lymphoma|hodgkin lymphoma]], [[thymoma]]
| align="left" style="background:#F5F5F5;" + |Malignancies such as:
* [[Hodgkin's lymphoma|Hodgkin lymphoma]]
* [[Thymoma]]
|-
|-
|Genetics: [[nephrin]] mutations, [[podocin]]
| align="left" style="background:#F5F5F5;" + |Genetic disorders such as:
* [[Nephrin]] mutations
* [[Podocin]] gene mutations
|-
|-
| rowspan="2" |[[Membranous glomerulonephritis]]
! rowspan="2" align="center" style="background:#DCDCDC;" + |[[Membranous glomerulonephritis]]
|Primary  
| align="left" style="background:#F5F5F5;" + |Primary  
|Primary [[membranous nephropathy]]
| align="left" style="background:#F5F5F5;" + |[[Membranous nephritis|Membranous nephropathy]]
|-
|-
|Secondary
| align="left" style="background:#F5F5F5;" + |Secondary
|Drugs, [[Toxin|toxins]], [[malignancies]]
| align="left" style="background:#F5F5F5;" + |
* [[Drugs]]
* [[Toxin|Toxins]]
* [[Cancer|Malignancies]]
|-
|-
|[[Membranoproliferative glomerulonephritis]]
! align="center" style="background:#DCDCDC;" + |[[Membranoproliferative glomerulonephritis]]
|Secondary
| align="left" style="background:#F5F5F5;" + |Secondary
|
| align="left" style="background:#F5F5F5;" + |
* Autoimmune disorders: [[SLE]], aquired C3 glomerulopathy
* Autoimmune disorders such as:
* Infections: [[Hepatitis C|HCV]], [[endocarditis]]
** [[SLE]]
** Aquired [[C3 glomerulopathy]]
* Infections such as:
** [[Hepatitis C|HCV]]
** [[Endocarditis]]
* [[Genetics]]
* [[Genetics]]
* [[Malignancies]]  
* [[Malignancies]]  
* [[Thrombotic microangiopathy]]
* [[Thrombotic microangiopathy]]
|-
|-
|Glomerular deposition diseases
! align="center" style="background:#DCDCDC;" + |Hereditary Nephropathy
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Alport syndrome]]
* [[IgA nephropathy]]
* C1q nephropathy
|-
! align="center" style="background:#DCDCDC;" + |[[Glomerular deposition disease|Glomerular deposition diseases]]
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Diabetes mellitus]]
* [[Diabetes mellitus]]
* [[Amyloidosis]]
* [[Amyloidosis]]
* [[Monoclonal antibodies|Monoclonal]] deposition disease
* [[Monoclonal antibodies|Monoclonal]] deposition disease
* Nodular glomeruloneohritis associated with heavy smoking
* Nodular glomeruloneohritis associated with heavy [[smoking]]
|-
|-
|Other lesions
! align="center" style="background:#DCDCDC;" + |Others
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Alport syndrome]]
* [[Fabry's disease|Fabry disease]]
* [[Fabry's disease|Fabry disease]]
* [[Nail-patella syndrome]]
* [[Nail-patella syndrome]]
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* [[Pre-eclampsia|Preeclampsia]]
* [[Pre-eclampsia|Preeclampsia]]
|}
|}
*Hereditary Nephropathies: are group of disorders that present with both the features of nephrotic and nephritic syndromes. When features of nephritic syndrome are associated with sensorineural deafness, it is called Alport’s syndrome. Other hereditary nephropathies include IgA Nephropathy, C1q Nephropathy, etc.
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Kidney diseases]]
 
[[Category:Medicine]]
[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Pediatrics]]
[[Category:Urology]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Syndromes]]
[[Category:Emergency medicine]]
[[Category:Needs overview]]
[[Category:Primary care]]
{{WH}}
{{WS}}

Latest revision as of 22:57, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3], Yazan Daaboul, Serge Korjian

Overview

Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology. Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary glomerular disease. The secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as infections, malignancies, systemic conditions, and medications.

Classification

  • Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.[1]
 
 
 
Nephrotic
syndrome
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary
 
 
 
Secondary
  • Below table lists different types of nephrotic syndromes:[2][3][4]
Different types of nephrotic syndromes Disease name
Podocytopathies Primary Minimal change disease
Focal segmental glomerulosclerosis (FSGS)
Secondary Infection such as:
Drugs/toxins such as:
  • NSAIDs
  • Interferon
  • Pamidronate
  • Lithium
  • Vaccins
  • Envenomation
Malignancies such as:
Genetic disorders such as:
Membranous glomerulonephritis Primary Membranous nephropathy
Secondary
Membranoproliferative glomerulonephritis Secondary
Hereditary Nephropathy
Glomerular deposition diseases
Others

References

  1. Kodner C (2009). "Nephrotic syndrome in adults: diagnosis and management". Am Fam Physician. 80 (10): 1129–34. PMID 19904897.
  2. Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ (May 2000). "Changing incidence of glomerular diseases in adults". Am. J. Kidney Dis. 35 (5): 878–83. PMID 10793022.
  3. Heaf J (September 2004). "The Danish Renal Biopsy Register". Kidney Int. 66 (3): 895–7. doi:10.1111/j.1523-1755.2004.00832.x. PMID 15327377.
  4. Ha TS (March 2017). "Genetics of hereditary nephrotic syndrome: a clinical review". Korean J Pediatr. 60 (3): 55–63. doi:10.3345/kjp.2017.60.3.55. PMC 5383633. PMID 28392820.