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| __NOTOC__
| | #redirest [[Cryopyrin-associated periodic syndrome]] |
| {{Infobox_Disease |
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| | Name = Neonatal onset multisystem inflammatory disease
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| | Image =
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| | Caption =
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| | DiseasesDB = 32178
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| | OMIM = 607115
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| | MedlinePlus =
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| | MeshID =
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| {{SI}}
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| {{CMG}}
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| {{SK}} NOMID; chronic neurologic cutaneous and articular syndrome; CINCA; CINCA syndrome; cryopyrin- associated periodic syndrome 3; CAPS3; neonatal-onset multisystemic inflammatory disease; chronic infantile neurological, cutaneous and articular syndrome
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| ==Overview==
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| '''Neonatal onset multisystem inflammatory disease''' (also known as '''NOMID''', '''Chronic Neurologic Cutaneous and Articular Syndrome''', or '''CINCA''') is a [[rare disease|rare]] genetic [[periodic fever syndrome]] which causes uncontrolled inflammation in multiple parts of the body starting in the newborn period. Symptoms include skin rashes, severe [[arthritis]], and chronic [[meningitis]] leading to neurologic damage.
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| NOMID can result from a mutation in the [[CIAS1]] gene, which helps control inflammation. Mutations in this gene also cause [[familial cold urticaria]] and [[Muckle-Wells syndrome]]. NOMID has been successfully treated with the drug [[anakinra]].
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| ==References==
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| *{{OMIM|607115}}
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| * Goldbach-Mansky, R. et al. ''Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1{beta} Inhibition'' N Engl J Med 2006 355: 581-592.
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| [[Category:Rheumatology]]
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| {{WH}}
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| {{WikiDoc Sources}}
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