Narcolepsy historical perspective: Difference between revisions
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*The [[Association (statistics)|association]] of [[occulomotor|oculomotor]] [[paralysis]] and [[somnolence]] led to the pioneering work of Von Economo (1930) who first recognized the [[posterior]] [[hypothalamus]] as a [[critical region]] for the promotion of [[wakefulness]] and correctly proposed that a region in the [[posterior]] [[hypothalamus]] was lesioned in [[human]] narcolepsy.<ref>Van Economo C. Sleep as a problem of localization. J. Nerv. Ment. Disease, 71(3): 249-259, 1930.</ref> He specifically wrote: “''it is very probable, though not proved, that the narcolepsy of Redlich, Westphal, and Gélineau has its primary [[Causes|cause]] in a yet unknown [[disease]] of that region''”. | *The [[Association (statistics)|association]] of [[occulomotor|oculomotor]] [[paralysis]] and [[somnolence]] led to the pioneering work of Von Economo (1930) who first recognized the [[posterior]] [[hypothalamus]] as a [[critical region]] for the promotion of [[wakefulness]] and correctly proposed that a region in the [[posterior]] [[hypothalamus]] was lesioned in [[human]] narcolepsy.<ref>Van Economo C. Sleep as a problem of localization. J. Nerv. Ment. Disease, 71(3): 249-259, 1930.</ref> He specifically wrote: “''it is very probable, though not proved, that the narcolepsy of Redlich, Westphal, and Gélineau has its primary [[Causes|cause]] in a yet unknown [[disease]] of that region''”. | ||
*The classic description of narcolepsy [[tetrad]] was possible due to further work by Yoss and Daly at the Mayo [[clinic]] in 1957 and Bedrich Roth in Prague.<ref>{{cite journal|doi=10.1159/isbn.978-3-318-05312-8}}</ref><ref name="pmid13441766">{{cite journal| author=YOSS RE, DALY DD| title=Criteria for the diagnosis of the narcoleptic syndrome. | journal=Proc Staff Meet Mayo Clin | year= 1957 | volume= 32 | issue= 12 | pages= 320-8 | pmid=13441766 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13441766 }} </ref> | *The classic description of narcolepsy [[tetrad]] was possible due to further work by Yoss and Daly at the Mayo [[clinic]] in 1957 and Bedrich Roth in Prague.<ref>{{cite journal|doi=10.1159/isbn.978-3-318-05312-8}}</ref><ref name="pmid13441766">{{cite journal| author=YOSS RE, DALY DD| title=Criteria for the diagnosis of the narcoleptic syndrome. | journal=Proc Staff Meet Mayo Clin | year= 1957 | volume= 32 | issue= 12 | pages= 320-8 | pmid=13441766 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13441766 }} </ref> | ||
*[[REM sleep]] at the onset of [[sleep]] attack in narcoleptic [[patients]] was first ever recorded and reported by Vogel (1960), an [[observation]] extended by Rechschaffen and Dement in 1967.<ref name="Vogel1960">{{cite journal|last1=Vogel|first1=Gerald|title=Studies in Psychophysiology of Dreams|journal=Archives of General Psychiatry|volume=3|issue=4|year=1960|pages=421|issn=0003-990X|doi=10.1001/archpsyc.1960.01710040091011}}</ref><ref name="pmid6083200">{{cite journal| author=Rechtschaffen A, Dement W| title=Studies on the relation of narcolepsy, cataplexy, and sleep with low voltage random EEG activity. | journal=Res Publ Assoc Res Nerv Ment Dis | year= 1967 | volume= 45 | issue= | pages= 488-505 | pmid=6083200 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6083200 }} </ref> Hishikawa (1968) studied the [[EEG]] of narcoleptic [[patients]]. These authors together first articulated the now classical [[hypothesis]] of dissociated [[REM sleep]] and explained some [[symptoms]] of narcolepsy. Their discovery established a multiple [[sleep latency]] [[test]] as a [[standard]] [[diagnostic test]] for narcolepsy in 1970. | *[[REM sleep]] at the onset of [[sleep]] attack in narcoleptic [[patients]] was first ever recorded and reported by Vogel (1960), an [[observation]] extended by Rechschaffen and Dement in 1967.<ref name="Vogel1960">{{cite journal|last1=Vogel|first1=Gerald|title=Studies in Psychophysiology of Dreams|journal=Archives of General Psychiatry|volume=3|issue=4|year=1960|pages=421|issn=0003-990X|doi=10.1001/archpsyc.1960.01710040091011}}</ref><ref name="pmid6083200">{{cite journal| author=Rechtschaffen A, Dement W| title=Studies on the relation of narcolepsy, cataplexy, and sleep with low voltage random EEG activity. | journal=Res Publ Assoc Res Nerv Ment Dis | year= 1967 | volume= 45 | issue= | pages= 488-505 | pmid=6083200 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6083200 }} </ref> Hishikawa (1968) studied the [[EEG]] of narcoleptic [[patients]].<ref name="pmid4169745">{{cite journal| author=Hishikawa Y, Nan'no H, Tachibana M, Furuya E, Koida H, Kaneko Z| title=The nature of sleep attack and other symptoms of narcolepsy. | journal=Electroencephalogr Clin Neurophysiol | year= 1968 | volume= 24 | issue= 1 | pages= 1-10 | pmid=4169745 | doi=10.1016/0013-4694(68)90060-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4169745 }} </ref> These authors together first articulated the now classical [[hypothesis]] of dissociated [[REM sleep]] and explained some [[symptoms]] of narcolepsy. Their discovery established a multiple [[sleep latency]] [[test]] as a [[standard]] [[diagnostic test]] for narcolepsy in 1970.<ref name="pmid81764">{{cite journal| author=Richardson GS, Carskadon MA, Flagg W, Van den Hoed J, Dement WC, Mitler MM| title=Excessive daytime sleepiness in man: multiple sleep latency measurement in narcoleptic and control subjects. | journal=Electroencephalogr Clin Neurophysiol | year= 1978 | volume= 45 | issue= 5 | pages= 621-7 | pmid=81764 | doi=10.1016/0013-4694(78)90162-1 | pmc=2391074 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=81764 }} </ref><ref name="pmid3809866">{{cite journal| author=Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan S| title=Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness. | journal=Sleep | year= 1986 | volume= 9 | issue= 4 | pages= 519-24 | pmid=3809866 | doi=10.1093/sleep/9.4.519 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3809866 }} </ref> | ||
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name]. | *In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name]. | ||
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name]. | *In [year], [gene] mutations were first implicated in the pathogenesis of [disease name]. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Muhammad Waleed Haider, M.D.[2]
Overview
Historical Perspective
Discovery
- The earliest account of narcolepsy was described by Thomas Willis (1621-1675) in patients, "with a sleepy disposition who suddenly falls fast asleep."
- The term narcolepsy is derived by combining the Greek narke numbness, stupor and lepsis attack, to seize.
- The first-ever convincing descriptions of narcolepsy and cataplexy were reported by Westphal (1877) and Fisher (1878) in Germany.[1][2] Both descriptions observed a hereditary factor in narcolepsy; the mother of Westphal's patient and a sister of Fisher's patient had similar clinical features. They also reported the unique association of excitement and sleepiness triggering episodes of muscle weakness.
- French physician Jean-Baptiste-Édouard Gélineau (1880) described this condition in a wine merchant as neurosis or a functional condition.[3] Gélineau gave narcolepsy its name, which is the English form of the French word narcolepsie, and recognized narcolepsy as a specific clinical entity.[4][5][6] Although Gélineau named this distinct clinical entity he did not differentiate episodes of muscle weakness and sleep attacks triggered by emotions as he proposed common physiology for these two distinct symptoms of narcolepsy.
- Cataplexy from the Greek kataplexis (fixation of the eyes), was first named by Loëwenfeld (1902) as he was the first to name brief episodes of muscle weakness triggered by emotions.[7]
- Kinnier Wilson (1928) first coined the term, "sleep paralysis."
- Large case series of narcolepsy with cataplexy was published by Addie (1926), Wilson (1927), and Daniels (1934).[8][9][10] Review of narcolepsy-cataplexy by Daniels is considered by many as one of the most insightful clinical reviews published.
- The association of oculomotor paralysis and somnolence led to the pioneering work of Von Economo (1930) who first recognized the posterior hypothalamus as a critical region for the promotion of wakefulness and correctly proposed that a region in the posterior hypothalamus was lesioned in human narcolepsy.[11] He specifically wrote: “it is very probable, though not proved, that the narcolepsy of Redlich, Westphal, and Gélineau has its primary cause in a yet unknown disease of that region”.
- The classic description of narcolepsy tetrad was possible due to further work by Yoss and Daly at the Mayo clinic in 1957 and Bedrich Roth in Prague.[12][13]
- REM sleep at the onset of sleep attack in narcoleptic patients was first ever recorded and reported by Vogel (1960), an observation extended by Rechschaffen and Dement in 1967.[14][15] Hishikawa (1968) studied the EEG of narcoleptic patients.[16] These authors together first articulated the now classical hypothesis of dissociated REM sleep and explained some symptoms of narcolepsy. Their discovery established a multiple sleep latency test as a standard diagnostic test for narcolepsy in 1970.[17][18]
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Landmark Events in the Development of Treatment Strategies
- Various methods were initially proposed in the treatment of narcolepsy until Prinzmetal and Bloomberg introduced amphetamines in 1935.[19]
- After the discovery of tricyclic antidepressants in 1957, Akimoto, Honda, and Takahashi used imipramine in the treatment of cataplexy in humans.[20]
- Methylphenidate was introduced by Yoss and Daly in the 1960s.[21]
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]:
References
- ↑ Fischer, Franz (1878). "Epileptoide Schlafzustände". Archiv für Psychiatrie und Nervenkrankheiten. 8 (1): 200–203. doi:10.1007/BF01791317. ISSN 0003-9373.
- ↑ Westphal C. Eigenthümliche mit Einschläfen verbundene Anfälle. Arch. Psychiat., 7: 631-635 1877.
- ↑ Schenck CH, Bassetti CL, Arnulf I, Mignot E (2007). "English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary". J Clin Sleep Med. 3 (3): 301–11. PMC 2564780. PMID 17561602.
- ↑ Janković S, Susić V, Sokić D, Lević Z (1996). "[Dr. John Baptiste Edouard Gélineau]". Srp Arh Celok Lek. 124 (11–12): 331–5. PMID 9132972.
- ↑ Gélineau J. De la narcolepsie. Gazette des hôpitaux,. 53: 626-628, 1880.
- ↑ Gélineau JBE. De la narcolepsie. Surgères, Charente-Inférieure: Imprimerie de Surgères, 64, 1881.
- ↑ Löwenfeld L. Uber Narkolepsie. Munch. Med. Wochenschr., 49: 1041-1045, 1902.
- ↑ Addie W. IdIopathic narcolepsy: a disease sui generis; with remarks on the mechanism of sleep. Brain, 49: 257-306, 1926.
- ↑ Wilson SAK. The narcolepsies. Annual Congress Assoc. Phys., June 3: 63-109, 1927.
- ↑ Daniels LE. Narcolepsy. Medicine, 13(1): 1-122, 1934.
- ↑ Van Economo C. Sleep as a problem of localization. J. Nerv. Ment. Disease, 71(3): 249-259, 1930.
- ↑ . doi:10.1159/isbn.978-3-318-05312-8. Missing or empty
|title=(help) - ↑ YOSS RE, DALY DD (1957). "Criteria for the diagnosis of the narcoleptic syndrome". Proc Staff Meet Mayo Clin. 32 (12): 320–8. PMID 13441766.
- ↑ Vogel, Gerald (1960). "Studies in Psychophysiology of Dreams". Archives of General Psychiatry. 3 (4): 421. doi:10.1001/archpsyc.1960.01710040091011. ISSN 0003-990X.
- ↑ Rechtschaffen A, Dement W (1967). "Studies on the relation of narcolepsy, cataplexy, and sleep with low voltage random EEG activity". Res Publ Assoc Res Nerv Ment Dis. 45: 488–505. PMID 6083200.
- ↑ Hishikawa Y, Nan'no H, Tachibana M, Furuya E, Koida H, Kaneko Z (1968). "The nature of sleep attack and other symptoms of narcolepsy". Electroencephalogr Clin Neurophysiol. 24 (1): 1–10. doi:10.1016/0013-4694(68)90060-6. PMID 4169745.
- ↑ Richardson GS, Carskadon MA, Flagg W, Van den Hoed J, Dement WC, Mitler MM (1978). "Excessive daytime sleepiness in man: multiple sleep latency measurement in narcoleptic and control subjects". Electroencephalogr Clin Neurophysiol. 45 (5): 621–7. doi:10.1016/0013-4694(78)90162-1. PMC 2391074. PMID 81764.
- ↑ Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan S (1986). "Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness". Sleep. 9 (4): 519–24. doi:10.1093/sleep/9.4.519. PMID 3809866.
- ↑ Prinzmetal, Myron (1935). "THE USE OF BENZEDRINE FOR THE TREATMENT OF NARCOLEPSY". Journal of the American Medical Association. 105 (25): 2051. doi:10.1001/jama.1935.02760510023006. ISSN 0002-9955.
- ↑ AKIMOTO H, HONDA Y, TAKAHASHI Y (1960). "Pharmacotherapy in narcolepsy". Dis Nerv Syst. 21: 704–6. PMID 13681922.
- ↑ Yoss, R. E.; Daly, D. (1959). "Treatment of narcolepsy with Ritalin". Neurology. 9 (3): 171–171. doi:10.1212/WNL.9.3.171. ISSN 0028-3878.