NWD1: Difference between revisions
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'''NWD1''', short for NACHT and WD repeat domain containing 1, is a [[gene]] found in [[vertebrate]]s, which encodes a protein that contains a [[NACHT domain]] and a [[WD40 repeat]] domain. It was originally identified during a search for [[immune system]] genes in [[zebrafish]] as a protein coding sequence related to [[APAF1]]; orthologs were subsequently identified in mammalian [[species]].<ref name="pmid18039395">{{cite journal |vauthors=Stein C, Caccamo M, Laird G, Leptin M |title=Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish |journal=Genome Biol. |volume=8 |issue=11 |pages=R251 |year=2007 |pmid=18039395 |pmc=2258186 |doi=10.1186/gb-2007-8-11-r251 |url=}}</ref> The ''NWD1'' gene of humans is located on [[chromosome 19]]. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.<ref>{{cite journal | vauthors = Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC | year = 2014 | title = The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling | url = | journal = Oncotarget | volume = 5 | issue = 6| pages = 1657–1665 }}</ref> | '''NWD1''', short for NACHT and WD repeat domain containing 1, is a [[gene]] found in [[vertebrate]]s, which encodes a protein that contains a [[NACHT domain]] and a [[WD40 repeat]] domain. It was originally identified during a search for [[immune system]] genes in [[zebrafish]] as a protein coding sequence related to [[APAF1]]; orthologs were subsequently identified in mammalian [[species]].<ref name="pmid18039395">{{cite journal |vauthors=Stein C, Caccamo M, Laird G, Leptin M |title=Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish |journal=Genome Biol. |volume=8 |issue=11 |pages=R251 |year=2007 |pmid=18039395 |pmc=2258186 |doi=10.1186/gb-2007-8-11-r251 |url=}}</ref> The ''NWD1'' gene of humans is located on [[chromosome 19]]. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.<ref>{{cite journal | vauthors = Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC | year = 2014 | title = The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling | url = | journal = Oncotarget | volume = 5 | issue = 6| pages = 1657–1665 | PMC=4039239 | doi = 10.18632/oncotarget.1850 | pmid=24681825}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 16:32, 10 December 2017
NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species.[1] The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.[2]
References
- ↑ Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11): R251. doi:10.1186/gb-2007-8-11-r251. PMC 2258186. PMID 18039395.
- ↑ Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC (2014). "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling". Oncotarget. 5 (6): 1657–1665. doi:10.18632/oncotarget.1850. PMC 4039239. PMID 24681825.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Correa RG, Ware CF, Reed JC (2014). "NLRs: Sentinels of innate immunity or cancer culprits?". Oncoscience. 1 (5): 308–9. doi:10.18632/oncoscience.44. PMC 4278305. PMID 25594025.
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