Morton's neuroma pathophysiology: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Line 7: Line 7:
==Pathophysiology==
==Pathophysiology==
===Pathogenesis===
===Pathogenesis===
*Symptomatic collapse of the transverse arch by perineural [[fibrosis]] around a plantar digital nerve of the foot due to traction and increased pressure/chronic compression on the interdigital nerve
*Morton's neuroma is associated with symptomatic collapse of the transverse arch by perineural [[fibrosis]] around a plantar digital nerve of the foot due to traction and increased pressure/chronic compression on the interdigital nerve
===Location===
===Location===
*Morton neuroma is characterized by being located at the:
*Morton neuroma is characterized by being located at the:
Line 25: Line 25:
**Epineural and endoneural arterial thickening/vascular hyalinization
**Epineural and endoneural arterial thickening/vascular hyalinization
**Degenerated/demyelinated axons
**Degenerated/demyelinated axons
[[File:Morton neuroma -- very high mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, very high magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_very_high_mag.jpg]]]
{|
{|
|
|
Line 35: Line 36:
[[File:Morton neuroma - alt 2 -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_-_alt_2_--_intermed_mag.jpg]]]
[[File:Morton neuroma - alt 2 -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_-_alt_2_--_intermed_mag.jpg]]]
|-
|-
[[File:Morton neuroma -- very high mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, very high magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_very_high_mag.jpg]]]
 
|
|
[[File:Morton neuroma -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_intermed_mag.jpg]]]
[[File:Morton neuroma -- intermed mag.jpg|thumb|200px|none| H&E stain of Morton's neuroma, Intermediate magnification [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Morton%27s_neuroma#/media/File:Morton_neuroma_--_intermed_mag.jpg]]]

Revision as of 20:05, 31 May 2019

Neurofibroma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neurofibroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Morton's neuroma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Morton's neuroma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Morton's neuroma pathophysiology

CDC on Morton's neuroma pathophysiology

Morton's neuroma pathophysiology in the news

Blogs on Morton's neuroma pathophysiology

Directions to Hospitals Treating Neurofibroma

Risk calculators and risk factors for Morton's neuroma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [8]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[9]

Overview

Neuroma

Pathophysiology

Pathogenesis

  • Morton's neuroma is associated with symptomatic collapse of the transverse arch by perineural fibrosis around a plantar digital nerve of the foot due to traction and increased pressure/chronic compression on the interdigital nerve

Location

  • Morton neuroma is characterized by being located at the:
    • Third intermetatarsal space most commonly (between third and fourth metatarsals)[1]
    • Second or fourth interspaces
    • Bifurcation of the fourth plantar digital nerve

Gross pathology

Histopathology

  • On microscopic histopathological analysis, characteristic findings of morton's neuroma include:[4][2][3]
    • Extensive fibrosis around and within the nerve
    • Digital artery
    • Thrombosis
    • Epineural and endoneural arterial thickening/vascular hyalinization
    • Degenerated/demyelinated axons
H&E stain of Morton's neuroma, very high magnification [1]
H&E stain of Morton's neuroma, low magnification [2]
H&E stain of Morton's neuroma, High magnification [3]
H&E stain of Morton's neuroma, Intermediate magnification [4]
H&E stain of Morton's neuroma, Intermediate magnification [5]
H&E stain of Morton's neuroma, Intermediate magnification [6]
H&E stain of Morton's neuroma, High magnification [7]

References

  1. ↑ Perry, Arie (2010). Practical surgical neuropathology : a diagnostic approach. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 978-0443069826.
  2. ↑ 2.0 2.1 Neuroma. Wikipedia. https://en.wikipedia.org/wiki/Neuroma Accessed on April 21, 2016
  3. ↑ 3.0 3.1 Wu J, Chiu DT (1999). "Painful neuromas: a review of treatment modalities". Ann Plast Surg. 43 (6): 661–7. PMID 10597831.
  4. ↑ Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Morton%27s_neuroma_pathophysiology&oldid=1570557"