Microangiopathic hemolytic anemia laboratory findings: Difference between revisions
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===Blood Tests=== | ===Blood Tests=== | ||
Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>: | Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>: | ||
===Complete Blood Count=== | ====Complete Blood Count==== | ||
* Normochromic normocytic [[anemia]] | * Normochromic normocytic [[anemia]] | ||
* [[Thrombocytopenia]] usually significant with [[platelet count]] less than 20,000/μL. | * [[Thrombocytopenia]] usually significant with [[platelet count]] less than 20,000/μL. | ||
| Line 17: | Line 17: | ||
* Raised mean [[platelet]] volume | * Raised mean [[platelet]] volume | ||
===Peripheral Blood Smear=== | ====Peripheral Blood Smear==== | ||
* [[Red cell]] polychromasia, anisocytosis, and normochromic appearance with a lack of central [[pallor]]. | * [[Red cell]] polychromasia, anisocytosis, and normochromic appearance with a lack of central [[pallor]]. | ||
* As [[red blood cell]]s travel through these damaged vessels, they are shredded. The result is [[red cell]] fragmentation and intravascular [[hemolysis]]. Under the microscope, damaged [[red cell]]s have the appearance of [[schistocyte]]s. It includes helmet [[cell]]s, irregular projections, and crescent-shape<ref name="pmid22081912">{{cite journal| author=Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH | display-authors=etal| title=ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. | journal=Int J Lab Hematol | year= 2012 | volume= 34 | issue= 2 | pages= 107-16 | pmid=22081912 | doi=10.1111/j.1751-553X.2011.01380.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22081912 }} </ref><ref name="pmid25882632">{{cite journal| author=Lesesve JF, Speyer E, Perol JP| title=Fragmented red cells reference range for the Sysmex XN®-series of automated blood cell counters. | journal=Int J Lab Hematol | year= 2015 | volume= 37 | issue= 5 | pages= 583-7 | pmid=25882632 | doi=10.1111/ijlh.12364 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25882632 }} </ref>. | * As [[red blood cell]]s travel through these damaged vessels, they are shredded. The result is [[red cell]] fragmentation and intravascular [[hemolysis]]. Under the microscope, damaged [[red cell]]s have the appearance of [[schistocyte]]s. It includes helmet [[cell]]s, irregular projections, and crescent-shape<ref name="pmid22081912">{{cite journal| author=Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH | display-authors=etal| title=ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. | journal=Int J Lab Hematol | year= 2012 | volume= 34 | issue= 2 | pages= 107-16 | pmid=22081912 | doi=10.1111/j.1751-553X.2011.01380.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22081912 }} </ref><ref name="pmid25882632">{{cite journal| author=Lesesve JF, Speyer E, Perol JP| title=Fragmented red cells reference range for the Sysmex XN®-series of automated blood cell counters. | journal=Int J Lab Hematol | year= 2015 | volume= 37 | issue= 5 | pages= 583-7 | pmid=25882632 | doi=10.1111/ijlh.12364 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25882632 }} </ref>. | ||
Revision as of 20:32, 21 January 2021
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Microangiopathic hemolytic anemia Microchapters |
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Differentiating Microangiopathic hemolytic anemia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Blood Tests
Laboratory findings consistent with the diagnosis of microangiopathic hemolytic anemia include[1]:
Complete Blood Count
- Normochromic normocytic anemia
- Thrombocytopenia usually significant with platelet count less than 20,000/μL.
- High reticulocyte count
- Raised red ce distribution width
- Raised mean platelet volume
Peripheral Blood Smear
- Red cell polychromasia, anisocytosis, and normochromic appearance with a lack of central pallor.
- As red blood cells travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes. It includes helmet cells, irregular projections, and crescent-shape[2][3].
- Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.
References
- ↑ Kottke-Marchant K (2017). "Diagnostic approach to microangiopathic hemolytic disorders". Int J Lab Hematol. 39 Suppl 1: 69–75. doi:10.1111/ijlh.12671. PMID 28447417.
- ↑ Zini G, d'Onofrio G, Briggs C, Erber W, Jou JM, Lee SH; et al. (2012). "ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes". Int J Lab Hematol. 34 (2): 107–16. doi:10.1111/j.1751-553X.2011.01380.x. PMID 22081912.
- ↑ Lesesve JF, Speyer E, Perol JP (2015). "Fragmented red cells reference range for the Sysmex XN®-series of automated blood cell counters". Int J Lab Hematol. 37 (5): 583–7. doi:10.1111/ijlh.12364. PMID 25882632.