Membranoproliferative glomerulonephritis history and symptoms: Difference between revisions

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==Overview==
==Overview==
MPGN has been assessed firstly based on the symptoms and signs of patients. These signs and symptoms are mostly related and same as kidneys disfunction such as, edema, hematuria and symptoms come after Nephrotic syndrome.
MPGN is assessed firstly based on the symptoms and signs of patients. These signs and symptoms are mostly related and same as kidneys dysfunction such as, [[edema]], [[hematuria]] and symptoms develop after [[Nephrotic syndrome]].The patients present with non specific symptoms of [[anorexia]], [[malaise]], [[Muscle weakness|weakness]], [[edema]].
 
== History ==
==History and Symptoms==
Patients will have positive history of:<ref name="pmid7723253">{{cite journal| author=Rennke HG| title=Secondary membranoproliferative glomerulonephritis. | journal=Kidney Int | year= 1995 | volume= 47 | issue= 2 | pages= 643-56 | pmid=7723253 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7723253  }} </ref>
Patients with MPGN may present in 1 of 5 ways, as follows:<ref>{{Cite journal|last=Elizabeth C. Jackson, MD, A. James McAdams, MD, C. Frederic Strife, MD, Judith Forristal, Thomas R. Welch, MD, Clark D. West, MD|first=|date=1987|title=Differences Between Membranoproliferative Glomerulonephritis Types I and III in Clinical Presentation, Glomerular Morphology, and Complement Perturbation|url=https://doi.org/10.1016/S0272-6386(87)80088-4|journal=American Journal of Kidney Disease|volume=9|pages=|via=}}</ref>
* [[Fever]]
:* Asymptomatic proteinuria and hematuria detected on routine urinalysis (23-30%)
* [[Weakness]]
:* Nephrotic syndrome (42-67%)
* [[Decreased urine output]]
:* Acute nephritic syndrome (16-30%)
* Periorbital edema
:* Recurrent episodes of gross hematuria (10-20%)
== Symptoms ==
:* Azotemia
Common symptoms of MPGN include:<ref name="pmid22435371">{{cite journal| author=Sethi S, Fervenza FC| title=Membranoproliferative glomerulonephritis--a new look at an old entity. | journal=N Engl J Med | year= 2012 | volume= 366 | issue= 12 | pages= 1119-31 | pmid=22435371 | doi=10.1056/NEJMra1108178 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22435371  }} </ref>
* Asymptomatic presentation: Proteinuria and hematuria may be detected on routine urinalysis, prompting further investigations.
* [[Periorbital edema]]
* Gross hematuria: Patients may have episodes of gross hematuria similar to those observed with immunoglobulin A (IgA) nephropathy. These episodes are usually associated with upper respiratory infection.
* [[Oliguria]]
* Edema: Periorbital or dependent edema may develop in patients with nephritic or nephrotic presentations.
* [[Hematuria|Haematuria]]
* Fatigue: This symptom is secondary to anemia or azotemia. The anemia often is disproportional to the degree of renal insufficiency and relates to complement-mediated lysis of red cells.
* [[Headaches]]
* Oliguria: Patients with an acute nephritic presentation may develop a decrease in urine output.
* [[Fatigue]]
* Azotemic symptoms: Patients may develop acute renal failure with the acute nephritic syndrome, which usually correlates with crescentic transformation on histology. Other patients may present with advanced chronic renal insufficiency.


==References==
==References==

Latest revision as of 20:48, 6 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

MPGN is assessed firstly based on the symptoms and signs of patients. These signs and symptoms are mostly related and same as kidneys dysfunction such as, edema, hematuria and symptoms develop after Nephrotic syndrome.The patients present with non specific symptoms of anorexia, malaise, weakness, edema.

History

Patients will have positive history of:[1]

Symptoms

Common symptoms of MPGN include:[2]

References

  1. Rennke HG (1995). "Secondary membranoproliferative glomerulonephritis". Kidney Int. 47 (2): 643–56. PMID 7723253.
  2. Sethi S, Fervenza FC (2012). "Membranoproliferative glomerulonephritis--a new look at an old entity". N Engl J Med. 366 (12): 1119–31. doi:10.1056/NEJMra1108178. PMID 22435371.

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