Membranoproliferative glomerulonephritis causes: Difference between revisions

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=== Common Causes ===
=== Common Causes ===
Common causes of [[Membranoproliferative glomerulonephritis|MPGN]] may include:
Common causes of [[Membranoproliferative glomerulonephritis|MPGN]] may include:<ref>{{Cite journal|last=H. Terence Cook and Matthew C. Pickering|first=|date=2014|title=Histopathology of MPGN and C3 glomerulopathies|url=|journal=NATURE REVIEWS NEPHROLOGY|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB|first=|date=1978|title=lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits|url=|journal=clinical immunology and immunopathology|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=Mårten Segelmark, Thomas Hellmark|first=|date=2010|title=Autoimmune kidney diseases|url=|journal=Elsevier|volume=|pages=|via=}}</ref>
* [[Immune complex]]–mediated disease
* [[Immune complex]]–mediated disease


:* [[Autoimmune disease]]<nowiki/>s<ref>{{Cite journal|last=H. Terence Cook and Matthew C. Pickering|first=|date=2014|title=Histopathology of MPGN and C3 glomerulopathies|url=|journal=NATURE REVIEWS NEPHROLOGY|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB|first=|date=1978|title=lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits|url=|journal=clinical immunology and immunopathology|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=Mårten Segelmark, Thomas Hellmark|first=|date=2010|title=Autoimmune kidney diseases|url=|journal=Elsevier|volume=|pages=|via=}}</ref>
:* [[Autoimmune disease]]<nowiki/>s
:** [[Systemic lupus erythematosus|Systemic lupus ery]]<nowiki/>[[Systemic lupus erythematosus|thematosus]] (SLE)
:** [[Systemic lupus erythematosus|Systemic lupus ery]]<nowiki/>[[Systemic lupus erythematosus|thematosus]] (SLE)
:** [[Sjögren's syndrome|Sjögren syndrome]]
:** [[Sjögren's syndrome|Sjögren syndrome]]
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** Fibrillary [[glomerulonephritis]]
** Fibrillary [[glomerulonephritis]]
* Non-Hodgkin lymphoma  
* Non-Hodgkin lymphoma  
* Renal cell carcinoma  
* [[Renal cell carcinoma]]
* Snake venom  
* Snake venom  
* Splenorenal shunt surgery for portal hypertension  
* Splenorenal shunt surgery for [[portal hypertension]]
* Melanoma  
* [[Melanoma]]
* Alpha-1-antitrypsin deficiency
* [[Alpha 1-antitrypsin deficiency|Alpha-1-antitrypsin deficiency]]
* Inherited complement deficiencies, specially C2 deficiency
* Inherited complement deficiencies, specially C2 deficiency


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{| style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" |No underlying causes
| style="width:75%" bgcolor="Beige" ; border="1" |[[Endocarditis]], infected ventriculoatrial (or jugular) shunt
|-
|-
| bgcolor="LightSteelBlue" |'''Chemical/Poisoning'''
| bgcolor="LightSteelBlue" |'''Chemical/Poisoning'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Snake venoms|Snake venom]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Dermatologic'''
|'''Dermatologic'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Melanoma]], [[Leprosy]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Gastroenterologic'''
|'''Gastroenterologic'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Celiac disease]], hepatitis B and C, chronic liver disease
Splenorenal shunt surgery for portal hypertension
 
[[Alpha 1-antitrypsin deficiency|Alpha-1-antitrypsin deficiency]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Genetic'''
|'''Genetic'''
| bgcolor="Beige" |(CFHR5)  gene mutation
| bgcolor="Beige" |(CFHR5)  gene mutation, [[Alpha 1-antitrypsin deficiency|Alpha-1-antitrypsin deficiency]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Hematologic'''
|'''Hematologic'''
| bgcolor="Beige" |[[Sickle cell anemia]], [[polycythemia]] and non-hodgkin lymphoma
| bgcolor="Beige" |[[Sickle cell anemia]], [[polycythemia]] and non-hodgkin lymphoma,
[[cryoglobulinemia]],
 
[[Lymphoma]]
 
[[Leukemia]]
 
[[Hemolytic-uremic syndrome|Hemolytic uremic syndrome]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Neurologic'''
|'''Neurologic'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Leprosy]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Pulmonary'''
|'''Pulmonary'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Mycoplasma pneumonia]], [[Alpha 1-antitrypsin deficiency|alpha-1-antitrypsin deficiency]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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[[Scleroderma]]
[[Scleroderma]]


[[Celiac disease|Celia]]<nowiki/>[[Celiac disease|c disease]]
[[Celiac disease|Celia]][[Celiac disease|c disease]]
 
[[Immunoglobulin]] light chain or heavy chain deposition diseases
 
 
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Urologic'''
|'''Urologic'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Hemolytic-uremic syndrome|Hemolytic uremic syndrome]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
|'''Miscellaneous'''
|'''Miscellaneous'''
| bgcolor="Beige" |No underlying causes
| bgcolor="Beige" |[[Chronic liver disease]] ([[cirrhosis]] and [[Alpha 1-antitrypsin deficiency|alpha1-antitrypsin deficiency]])
|-
|-
|}
|}

Revision as of 16:41, 30 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Nazia Fuad M.D.

Overview

The most common causes for membranoproliferative glomerulonephritis autoimmune diseases, mainly systemic lupus erythematosus (SLE), Sjögren syndrome, rheumatoid arthritis, inherited complement deficiencies (esp C2 deficiency), scleroderma, Celiac disease .Chronic infections also play major role such as viral infections like hepatitis B, hepatitis C, and cryoglobulinemia type II, bacterial infections such as endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy. Protozoal - malaria, schistosomiasis. Rare causes of MPGN include non-Hodgkin lymphoma, renal cell carcinoma, snake venom, splenorenal shunt surgery for portal hypertension , melanoma, alpha-1-antitrypsin deficiency, and cryoglobulinemic glomerulonephritis and Idiopathic MPGN .

Causes

life- threatning causes

There are no life-threatening causes of membranoproliferative glomerulonephritis. , however complications resulting from untreated membranoproliferative glomerulonephritis. is common.

Common Causes

Common causes of MPGN may include:[1][2][3]

Less Common Causes

Less common causes of MPGN include

    • MPGN type I
    • MPGN type II or dense deposit disease.
    • MPGN type III
  • Paraprotein deposition diseases

Genetic Causes

  • MPGN is caused by a mutation in the complement factor H-related protein 5 (CFHR5) gene.

Causes by Organ System

Cardiovascular Endocarditis, infected ventriculoatrial (or jugular) shunt
Chemical/Poisoning Snake venom
Dental No underlying causes
Dermatologic Melanoma, Leprosy
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Celiac disease, hepatitis B and C, chronic liver disease

Splenorenal shunt surgery for portal hypertension

Alpha-1-antitrypsin deficiency

Genetic (CFHR5) gene mutation, Alpha-1-antitrypsin deficiency
Hematologic Sickle cell anemia, polycythemia and non-hodgkin lymphoma,

cryoglobulinemia,

Lymphoma

Leukemia

Hemolytic uremic syndrome

Iatrogenic No underlying causes
Infectious Disease Viral - hepatitis B, hepatitis C, and cryoglobulinemia type II

Bacterial - endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy

Protozoal - malaria, schistosomiasis

Other infections - mycoplasma, lyme Disease

Musculoskeletal/Orthopedic No underlying causes
Neurologic Leprosy
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Lymphoma, leukemia, carcinoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Mycoplasma pneumonia, alpha-1-antitrypsin deficiency
Renal/Electrolyte Rnal cell carcinoma

Hemolytic uremic syndrome

Radiation nephritis

Nephropathy associated with bone marrow transplantation

Transplant glomerulopathy

Rheumatology/Immunology/Allergy Systemic lupus erythematosus (SLE)

Sjögren syndrome

Rheumatoid arthritis

Scleroderma

Celiac disease

Immunoglobulin light chain or heavy chain deposition diseases


Sexual No underlying causes
Trauma No underlying causes
Urologic Hemolytic uremic syndrome
Miscellaneous Chronic liver disease (cirrhosis and alpha1-antitrypsin deficiency)

References

  1. ↑ H. Terence Cook and Matthew C. Pickering (2014). "Histopathology of MPGN and C3 glomerulopathies". NATURE REVIEWS NEPHROLOGY.
  2. ↑ MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB (1978). "lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits". clinical immunology and immunopathology.
  3. ↑ Mårten Segelmark, Thomas Hellmark (2010). "Autoimmune kidney diseases". Elsevier.
  4. ↑ Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD (2004). "MPGN Secondary to Lyme Disease". American Journal of Kidney Diseases. 43.
  5. ↑ Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock (2012). "Idiopathic membranoproliferative glomerulonephritis: does it exist?". Nephrology Dialysis Transplantation ( NDT ).

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