Medullary thyroid cancer biopsy: Difference between revisions

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{{Medullary thyroid cancer}}
{{Medullary thyroid cancer}}
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Gallery<ref name="urlMedullary thyroid carcinoma - Libre Pathology">{{cite web |url=https://librepathology.org/wiki/Medullary_thyroid_carcinoma |title=Medullary thyroid carcinoma - Libre Pathology |format= |work= |accessdate=}}</ref>==
==Key Biopsy Findings in Medullary Thyroid Cancer==
===Microscopic Pathology===
* Microscopic features of medullary thyroid cancer is as follows:
====Cytoplasm and Nuclei====
:* Nested with delicate vascular septa
:* Trabecular
:* Tubular/glandular, pseudo-papillary cells
:* Polygonal to spindle to small cells
:* Amphophilic, somewhat granular cytoplasm
:* Interstitial edema
:* Stroma may have +/-Amyloid deposits with fluffy appearing acellular eosinophilic material in the cytoplasm.
:* Stroma is vascular and can show hemorrhage, hyalinised collagen, oedema or metaplastic bone
:* Coarse calcification and psammoma bodies may be present
:* Nuclei with "neuroendocrine features".
:* Small, round nuclei.
:* Coarse chromatin (salt and pepper nuclei).
====Surrounding Thyroid====
:* +/-C-cell hyperplasia - seen with familial forms of MTC.
:* C cells (AKA parafollicular cell): abundant cytoplasm - clear/pale.
==Biopsy Exams of Medullary Thyroid Cancer==
<gallery>
<gallery>
Image:Medullary thyroid carcinoma - low mag.jpg| Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
Image:Medullary thyroid carcinoma - low mag.jpg| Low magnification micrograph of medullary thyroid carcinoma
(2015). http://librepathology.org/wiki/index.php/File:Medullary_thyroid_carcinoma_-_low_mag.jpg  Accessed on November 12, 2015</ref>
Image:Medullary thyroid carcinoma - high mag.jpg| High magnification micrograph of medullary thyroid carcinoma
Image:Medullary thyroid carcinoma - high mag.jpg| High magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
Image:Medullary thyroid carcinoma - 2 - high mag.jpg| High magnification micrograph of medullary thyroid carcinoma
(2015). http://librepathology.org/wiki/index.php/File:Medullary_thyroid_carcinoma_-_high_mag.jpg  Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma 217 PA.JPG| Low magnification micrograph of medullary thyroid carcinoma
Image:Medullary thyroid carcinoma - 2 - high mag.jpg| High magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
Image:800px-Thyroid MedullaryCarcinoma Amyloid RBWH.JPG| Medullary thyroid carcinoma amyloid
(2015). http://www.wikidoc.org/index.php/File:Medullary_thyroid_carcinoma_-_2_-_high_mag.jpg  Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma Amyloid MP3 PA.JPG| Medullary thyroid carcinoma amyloid
Image:Thyroid MedullaryCarcinoma 217 PA.JPG| Low magnification micrograph of medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
Image:Thyroid MedullaryCarcinoma Amyloid MP2 PA.JPG| Medullary thyroid carcinoma amyloid
(2015). http://librepathology.org/wiki/index.php/File:Thyroid_MedullaryCarcinoma_217_PA.JPG  Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma Amyloid MP4 PA.JPG| Medullary thyroid carcinoma amyloid
Image:800px-Thyroid MedullaryCarcinoma Amyloid RBWH.JPG| Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
Image:Thyroid MedullaryCarcinoma Amyloid MP PA.JPG| Medullary thyroid carcinoma amyloid
(2015). http://librepathology.org/wiki/index.php/File:Thyroid_MedullaryCarcinoma_217_PA.JPG  Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma Comedonecrosis LP2 CTR.jpg| Medullary thyroid carcinoma comedonecrosis
Image:Thyroid MedullaryCarcinoma Amyloid MP3 PA.JPG| Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
Image:Thyroid MedullaryCarcinoma Comedonecrosis HP CTR.jpg| Medullary thyroid carcinoma comedonecrosis
(2015). http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SpindleCell LP PA.JPG| Medullary thyroid carcinoma comedonecrosis
Image:Thyroid MedullaryCarcinoma Amyloid MP2 PA.JPG| Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
Image:Thyroid MedullaryCarcinoma SpindleCell MP PA.JPG| Medullary thyroid carcinoma spindle cell
(2015). http://librepathology.org/wiki/index.php/File:Thyroid_MedullaryCarcinoma_Amyloid_MP2_PA.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SpindleCell LP2 PA.JPG| Medullary thyroid carcinoma spindle cell
Image:Thyroid MedullaryCarcinoma Amyloid MP4 PA.JPG| Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
Image:Thyroid MedullaryCarcinoma SmallCell HP PA.JPG| Medullary thyroid carcinoma spindle cell
(2015). http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SmallCellVariant MP CTR.jpg| Medullary thyroid carcinoma spindle cell
Image:Thyroid MedullaryCarcinoma Amyloid MP PA.JPG| Medullary thyroid carcinoma amyloid<ref> Medullary thyroid cancer librepathology
Image:Thyroid MedullaryCarcinoma SmallCellVariant HP CTR (3).jpg| Medullary thyroid carcinoma spindle cell
(2015). http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma Amyloid HP PA.JPG| Medullary thyroid carcinoma
Image:Thyroid MedullaryCarcinoma Comedonecrosis LP2 CTR.jpg| Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
(2015). http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma Comedonecrosis HP CTR.jpg| Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
(2015). http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SpindleCell LP PA.JPG| Medullary thyroid carcinoma comedonecrosis<ref> Medullary thyroid cancer librepathology
(2015). http://librepathology.org/wiki/index.php/File:Thyroid_MedullaryCarcinoma_SpindleCell_LP_PA.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SpindleCell MP PA.JPG| Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
(2015). http://librepathology.org/wiki/index.php/File:Thyroid_MedullaryCarcinoma_SpindleCell_MP_PA.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SpindleCell LP2 PA.JPG| Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
(2015).http://librepathology.org/wiki/index.php/File:Thyroid_MedullaryCarcinoma_SpindleCell_LP2_PA.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SmallCell HP PA.JPG| Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
(2015).http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SmallCellVariant MP CTR.jpg| Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
(2015).http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma SmallCellVariant HP CTR (3).jpg| Medullary thyroid carcinoma spindle cell<ref> Medullary thyroid cancer librepathology
(2015).http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma.JPG Accessed on November 12, 2015</ref>
Image:Thyroid MedullaryCarcinoma Amyloid HP PA.JPG| Medullary thyroid carcinoma<ref> Medullary thyroid cancer librepathology
(2015).http://librepathology.org/wiki/index.php/Medullary_thyroid_carcinoma.JPG Accessed on November 12, 2015</ref>
 
</gallery>
</gallery>
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Endocrine system]]
[[Category:Endocrinology]]
[[Category:Otolaryngology]]
[[Category:Disease]]
[[Category:Genetic disorders]]
[[Category:Types of cancer]]
[[Category:Hereditary cancers]]

Latest revision as of 18:01, 21 August 2019

Medullary thyroid cancer Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Gallery[1]

  • Low magnification micrograph of medullary thyroid carcinoma

    Low magnification micrograph of medullary thyroid carcinoma

  • High magnification micrograph of medullary thyroid carcinoma

    High magnification micrograph of medullary thyroid carcinoma

  • High magnification micrograph of medullary thyroid carcinoma

    High magnification micrograph of medullary thyroid carcinoma

  • Low magnification micrograph of medullary thyroid carcinoma

    Low magnification micrograph of medullary thyroid carcinoma

  • Medullary thyroid carcinoma amyloid

    Medullary thyroid carcinoma amyloid

  • Medullary thyroid carcinoma amyloid

    Medullary thyroid carcinoma amyloid

  • Medullary thyroid carcinoma amyloid

    Medullary thyroid carcinoma amyloid

  • Medullary thyroid carcinoma amyloid

    Medullary thyroid carcinoma amyloid

  • Medullary thyroid carcinoma amyloid

    Medullary thyroid carcinoma amyloid

  • Medullary thyroid carcinoma comedonecrosis

    Medullary thyroid carcinoma comedonecrosis

  • Medullary thyroid carcinoma comedonecrosis

    Medullary thyroid carcinoma comedonecrosis

  • Medullary thyroid carcinoma comedonecrosis

    Medullary thyroid carcinoma comedonecrosis

  • Medullary thyroid carcinoma spindle cell

    Medullary thyroid carcinoma spindle cell

  • Medullary thyroid carcinoma spindle cell

    Medullary thyroid carcinoma spindle cell

  • Medullary thyroid carcinoma spindle cell

    Medullary thyroid carcinoma spindle cell

  • Medullary thyroid carcinoma spindle cell

    Medullary thyroid carcinoma spindle cell

  • Medullary thyroid carcinoma spindle cell

    Medullary thyroid carcinoma spindle cell

  • Medullary thyroid carcinoma

    Medullary thyroid carcinoma

References

  1. ↑ "Medullary thyroid carcinoma - Libre Pathology".
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