Medium-sized vessel vasculitis with headache, fever, weight loss, arthralgia, claudication, bruit, and hypertension: Difference between revisions
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[[Category:Rheumatology]] |
Latest revision as of 22:40, 29 July 2020
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]
Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Physical examination | ||||||||||||||||||||
Lab Findings | Imaging | Histopathology | |||||||||||||||||||
Headache | Fever | Weight loss | Arthralgia | Claudication | Bruit | HTN | Focal neurological disorder | Biomarker | CBC | ESR | Other | CT scan | Angiography | Ultrasound/ Echocardiography | Other | ||||||
Medium-Vessel Vasculitis | Polyarteritis nodosa[1] | + | + | + | + | + | + | +/- | +/- | LAMP-2 protein autoantibodies | Leukocytosis, Normochromic anemia, Thrombocytosis | ↑ | ↑ Cr or BUN,
↑ ALT or AST, Proteinuria |
Focal regions of infarction or hemorrhage | Multiple microaneurysms, Hemorrhage due to focal rupture, Occlusion | Aneurysms and renal arteriovenous fistula in color Doppler sonography | - | Necrotizing inflammatory lesions | Angiography | Sudden weight loss, Abdominal pain | |
Hepatitis B virus-associated polyarteritis nodosa[2] | +/- | +/- | + | + | +/- | +/- | + | - | HBsAg | Leukocytosis, Normochromic anemia, Thrombocytosis | ↑ | ↑ ALT or AST | Focal regions of infarction or hemorrhage | Microaneurysms in mesenteric artery | Aneurysms and renal arteriovenous fistula in color Doppler sonography | - | Necrotizing inflammatory lesions | Angiography | Peripheral neuropathy, Livedo reticularis |
References
- ↑ Howard T, Ahmad K, Swanson JA, Misra S (2014). "Polyarteritis nodosa". Tech Vasc Interv Radiol. 17 (4): 247–51. doi:10.1053/j.tvir.2014.11.005. PMC 4363102. PMID 25770638.
- ↑ Sharma A, Sharma K (September 2013). "Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis". J Clin Exp Hepatol. 3 (3): 204–12. doi:10.1016/j.jceh.2013.06.001. PMC 4216827. PMID 25755502.