Map44
| mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | |
|---|---|
| Identifiers | |
| Symbol | MASP1 |
| Alt. symbols | CRARF, PRSS5 |
| Entrez | 5648 |
| HUGO | 6901 |
| OMIM | 600521 |
| RefSeq | NM_001879 |
| UniProt | P48740 |
| Other data | |
| Locus | Chr. 3 q27-q28 |
Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]
See also
References
- ↑ Degn, Søren; Annette G. Hansen; Rudi Steffensen; Christian Jacobsen; Jens C. Jensenius; Steffen Thiel (November 2009). "MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation". Journal of Immunology. 183 (11): 7371–7378. doi:10.4049/jimmunol.0902388. PMID 19917686.
External links
- MASP+Proteases at the US National Library of Medicine Medical Subject Headings (MeSH)
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