Mantle cell lymphoma laboratory findings: Difference between revisions
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{{ Mantle cell lymphoma }} | {{ Mantle cell lymphoma }} | ||
{{CMG}}; {{AE}} {{AS}} | |||
==Overview== | |||
Laboratory tests of mantle cell lymphoma include histologic confirmation, [[genetic testing]], and [[immunophenotyping]]. | |||
==Laboratory tests== | |||
Laboratory tests of mantle cell lymphoma include<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>: | |||
* Histologic confirmation | |||
* [[Genetic testing]] | |||
:* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases | |||
:* Overexpression CYCLIN D [[mRNA]] | |||
:* Mutation or deletions of ''ATM gene'' | |||
* [[Immunophenotyping]]: ''BCL6-'', [[CD5]]+, [[CD10]]-, [[CD23]]- (or weakly positive), [[CD43]]+, FMC7+ | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Blood disorders]] | [[Category:Blood disorders]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category :Hematology]] | [[Category :Hematology]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 13:44, 1 September 2015
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Mantle cell lymphoma Microchapters |
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Mantle cell lymphoma laboratory findings On the Web |
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Risk calculators and risk factors for Mantle cell lymphoma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Laboratory tests of mantle cell lymphoma include histologic confirmation, genetic testing, and immunophenotyping.
Laboratory tests
Laboratory tests of mantle cell lymphoma include[1]:
- Histologic confirmation
- Genetic testing
- Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
- Overexpression CYCLIN D mRNA
- Mutation or deletions of ATM gene
- Immunophenotyping: BCL6-, CD5+, CD10-, CD23- (or weakly positive), CD43+, FMC7+
References
- ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov