Macrocytic anemia historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Historical Perspective
Discovery
Following facts were found in historical perspective:[1]
- Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal.
- Increase in bone marrow cellls was noted by Cohnheim in 1876.
- The association between megaloblastic(pernicious) anemia and spinal cord lesions was made in 1887 by Lichtheim.
- Subacute combined degeneration of spinal cord was coined by Russell et al in 1900.
- In 1908, Cabot was the first to discover the association between megaloblastic anemia and the development of numbness and tingling of extremities.
- In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like liver, muscle meat, leafy vegetables, eggs and milk. they discovered rises in cell count and hemoglobin levels.
- In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for medicine and physiology for saving the lives of anemic people with dietary measures.
Outbreaks
There have been several outbreaks of [disease name], which are summarized below:
Landmark Events in the Development of Treatment Strategies
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].