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{{Infobox_gene}}
{{PBB_Controls
'''Microtubule-associated serine/threonine-protein kinase 2''' is an [[enzyme]] that in humans is encoded by the ''MAST2'' [[gene]].<ref name="entrez_ 23139">{{cite web | title = Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23139| accessdate = }}</ref> The [[protein]] encoded by this gene  controls [[TRAF6]] and [[NF-κB|NF-kappaB]] activity.<ref name="pmid 15308666">{{cite journal | vauthors = Xiong H, Li H, Chen Y, Zhao J, Unkeless JC | title = Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability | journal = J. Biol. Chem. | volume = 279 | issue = 42 | pages = 43675–83 | year = 2004 | pmid = 15308666 | doi = 10.1074/jbc.M404328200 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Microtubule associated serine/threonine kinase 2
| HGNCid = 19035
| Symbol = MAST2
| AltSymbols =; FLJ39200; KIAA0807; MAST205; MTSSK; RP4-533D7.1
| OMIM = 
| ECnumber = 
| Homologene = 7428
| MGIid = 894676
| GeneAtlas_image1 = PBB_GE_MAST2_211593_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAST2_215660_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MAST2_215903_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019902 |text = phosphatase binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0045075 |text = regulation of interleukin-12 biosynthetic process}} {{GNF_GO|id=GO:0048515 |text = spermatid differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23139
    | Hs_Ensembl = ENSG00000086015
    | Hs_RefseqProtein = NP_055927
    | Hs_RefseqmRNA = NM_015112
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 46041872
    | Hs_GenLoc_end = 46274383
    | Hs_Uniprot = Q6P0Q8
    | Mm_EntrezGene = 17776
    | Mm_Ensembl = ENSMUSG00000003810
    | Mm_RefseqmRNA = NM_001042743
    | Mm_RefseqProtein = NP_001036208
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 115804694
    | Mm_GenLoc_end = 115961780
    | Mm_Uniprot = Q9DBV8
  }}
}}
'''Microtubule associated serine/threonine kinase 2''', also known as '''MAST2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23139| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
MAST2 has been shown to [[Protein-protein interaction|interact]] with [[PCLKC]].<ref name=pmid12117771>{{cite journal | vauthors = Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H | title = Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation | journal = Carcinogenesis | volume = 23 | issue = 7 | pages = 1139–48  | date = July 2002 | pmid = 12117771 | doi = 10.1093/carcin/23.7.1139 }}</ref>
{{PBB_Summary
 
| section_title =  
== Model organisms ==
| summary_text =  
 
}}
[[Model organism]]s have been used in the study of MAST2 function. A conditional [[knockout mouse]] line called ''Mast2<sup>tm1a(KOMP)Wtsi</sup>'' has been generated.<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Mast2#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Mast2&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>  
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Mast2'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />{
|-
| Insulin || bgcolor="#488ED3"|Normal
 
|-
| Homozygous viability at P14 || bgcolor="#488ED3"|Normal
 
|-
| Homozygous Fertility || bgcolor="#488ED3"|Normal
 
|-
| Body weight || bgcolor="#488ED3"|Normal
 
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
 
|-
| Grip strength || bgcolor="#488ED3"|Normal
 
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#488ED3"|Normal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Heart weight || bgcolor="#488ED3"|Normal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
| Cytotoxic T Cell Function || bgcolor="#488ED3"|Normal
 
|-
| Influenza Challenge || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear|left}}


==References==
==References==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Walden PD, Cowan NJ | title = A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette | journal = Mol. Cell. Biol. | volume = 13 | issue = 12 | pages = 7625–35 | year = 1993 | pmid = 8246979 | pmc = 364834 | doi =  10.1128/mcb.13.12.7625}}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Walden PD, Cowan NJ |title=A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7625-35 |year= 1994 |pmid= 8246979 |doi=  }}
* {{cite journal | vauthors = Walden PD, Millette CF | title = Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis | journal = Biol. Reprod. | volume = 55 | issue = 5 | pages = 1039–44 | year = 1996 | pmid = 8902215 | doi = 10.1095/biolreprod55.5.1039 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 5 | pages = 277–86 | year = 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
*{{cite journal | author=Walden PD, Millette CF |title=Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis. |journal=Biol. Reprod. |volume=55 |issue= 5 |pages= 1039-44 |year= 1997 |pmid= 8902215 |doi= }}
* {{cite journal | vauthors = Lumeng C, Phelps S, Crawford GE, Walden PD, Barald K, Chamberlain JS | title = Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases | journal = Nat. Neurosci. | volume = 2 | issue = 7 | pages = 611–7 | year = 1999 | pmid = 10404183 | doi = 10.1038/10165 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
* {{cite journal | vauthors = Adey NB, Huang L, Ormonde PA, Baumgard ML, Pero R, Byreddy DV, Tavtigian SV, Bartel PL | title = Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding | journal = Cancer Res. | volume = 60 | issue = 1 | pages = 35–7 | year = 2000 | pmid = 10646847 | doi =  }}
*{{cite journal | author=Lumeng C, Phelps S, Crawford GE, ''et al.'' |title=Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. |journal=Nat. Neurosci. |volume=2 |issue= 7 |pages= 611-7 |year= 1999 |pmid= 10404183 |doi= 10.1038/10165 }}
* {{cite journal | vauthors = Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H | title = Interaction of the type IIa Na/Pi cotransporter with PDZ proteins | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 9206–13 | year = 2001 | pmid = 11099500 | doi = 10.1074/jbc.M008745200 }}
*{{cite journal | author=Adey NB, Huang L, Ormonde PA, ''et al.'' |title=Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 35-7 |year= 2000 |pmid= 10646847 |doi=  }}
* {{cite journal | vauthors = Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H | title = Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation | journal = Carcinogenesis | volume = 23 | issue = 7 | pages = 1139–48 | year = 2002 | pmid = 12117771 | doi = 10.1093/carcin/23.7.1139 }}
*{{cite journal | author=Gisler SM, Stagljar I, Traebert M, ''et al.'' |title=Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 9206-13 |year= 2001 |pmid= 11099500 |doi= 10.1074/jbc.M008745200 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal | author=Okazaki N, Takahashi N, Kojima S, ''et al.'' |title=Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. |journal=Carcinogenesis |volume=23 |issue= 7 |pages= 1139-48 |year= 2002 |pmid= 12117771 |doi= }}
* {{cite journal | vauthors = Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I | title = Proteomic identification of brain proteins that interact with dynein light chain LC8 | journal = Proteomics | volume = 4 | issue = 2 | pages = 339–46 | year = 2004 | pmid = 14760703 | doi = 10.1002/pmic.200300528 }}
*{{cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
* {{cite journal | vauthors = Zhou H, Xiong H, Li H, Plevy SE, Walden PD, Sassaroli M, Prestwich GD, Unkeless JC | title = Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation | journal = J. Immunol. | volume = 172 | issue = 4 | pages = 2559–68 | year = 2004 | pmid = 14764729 | doi = 10.4049/jimmunol.172.4.2559 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nat. Biotechnol. | volume = 22 | issue = 6 | pages = 707–16 | year = 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Xiong H, Li H, Chen Y, Zhao J, Unkeless JC | title = Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability | journal = J. Biol. Chem. | volume = 279 | issue = 42 | pages = 43675–83 | year = 2004 | pmid = 15308666 | doi = 10.1074/jbc.M404328200 }}
*{{cite journal  | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, ''et al.'' |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339-46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Zhou H, Xiong H, Li H, ''et al.'' |title=Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation. |journal=J. Immunol. |volume=172 |issue= 4 |pages= 2559-68 |year= 2004 |pmid= 14764729 |doi= }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Xiong H, Li H, Chen Y, ''et al.'' |title=Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability. |journal=J. Biol. Chem. |volume=279 |issue= 42 |pages= 43675-83 |year= 2004 |pmid= 15308666 |doi= 10.1074/jbc.M404328200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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{{Serine/threonine-specific protein kinases}}
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[[Category:EC 2.7.11]]

Latest revision as of 02:11, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.[1] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.[2]

Interactions

MAST2 has been shown to interact with PCLKC.[3]

Model organisms

Model organisms have been used in the study of MAST2 function. A conditional knockout mouse line called Mast2tm1a(KOMP)Wtsi has been generated.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10]

References

  1. ↑ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2".
  2. ↑ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666.
  3. ↑ Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
  4. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ 5.0 5.1 "International Mouse Phenotyping Consortium".
  6. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  7. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  8. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  9. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  10. ↑ 10.0 10.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=MAST2&oldid=1411837"